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Active surveillance should not be routinely considered in ISUP grade group 2 prostate cancer
Active surveillance has been proposed as a therapeutic option in selected intermediate risk patients with biopsy grade group 2 prostate cancer....
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Biparametric MRI in prostate cancer during active surveillance: is it safe?
AbstractActive surveillance (AS) is the preferred option for patients presenting with low-intermediate-risk prostate cancer. MRI now plays a crucial...
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No detrimental effect of a positive family history on postoperative upgrading and upstaging in men with low risk and favourable intermediate-risk prostate cancer: implications for active surveillance
PurposeTo assess whether a first-degree family history or a fatal family history of prostate cancer (PCa) are associated with postoperative upgrading...
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Intratumoural immunotherapy plus focal thermal ablation for localized prostate cancer
Major advances have been made in the use of immunotherapy for the treatment of solid tumours, including the use of intratumourally injected...
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The potential role of the microbiota in prostate cancer pathogenesis and treatment
The human body hosts a complex and dynamic population of trillions of microorganisms — the microbiota — which influences the body in homeostasis and...
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Using PSMA imaging for prognostication in localized and advanced prostate cancer
The use of prostate-specific membrane antigen (PSMA)-directed applications in modern prostate cancer management has evolved rapidly over the past few...
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Relationships between holmium laser enucleation of the prostate and prostate cancer
Holmium laser enucleation of the prostate (HoLEP) is a size-independent surgical option for treating benign prostatic hyperplasia (BPH) and lower...
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The prognostic role of next-generation imaging-driven upstaging in newly diagnosed prostate cancer patients
PurposePhase III evidence showed that next-generation imaging (NGI), such as prostate-specific membrane antigen positron emission tomography/computed...
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The yin and yang of chromosomal instability in prostate cancer
Metastatic prostate cancer remains an incurable lethal disease. Studies indicate that prostate cancer accumulates genomic changes during disease...
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Management of oligometastatic prostate cancer
PurposeThis study aimed to review the current management strategies for oligometastatic prostate cancer (omPCa), focusing on their clinical...
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The current role of MRI for guiding active surveillance in prostate cancer
Active surveillance (AS) is the recommended treatment option for low-risk and favourable intermediate-risk prostate cancer management, preserving...
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Key learning on the promise and limitations of MRI in prostate cancer screening
AbstractMRI retains its ability to reduce the harm of prostate biopsies by decreasing biopsy rates and the detection of indolent cancers in...
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MR-Guided Transurethral Ultrasound Ablation (TULSA)—An Emerging Minimally Invasive Treatment Option for Localised Prostate Cancer
The optimal treatment strategy for men with localised prostatic cancer of low and intermediate risk is an actively evolving field. It is important to...
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Biological determinants of PSMA expression, regulation and heterogeneity in prostate cancer
Prostate-specific membrane antigen (PSMA) is an important cell-surface imaging biomarker and therapeutic target in prostate cancer. The PSMA-targeted...
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Head-to-head comparisons of [68Ga]Ga-PSMA-11 PET/CT, multiparametric MRI, and prostate-specific antigen for the evaluation of therapeutic responses to neoadjuvant chemohormonal therapy in high-risk non-metastatic prostate cancer patients: a prospective study
PurposeThe optimal tool to evaluate the tumour therapeutic responses to neoadjuvant chemohormonal therapy (NCHT) in patients with high-risk...
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Prostate-specific membrane antigen (PSMA) radioguided surgery in prostate cancer: An overview of current application and future perspectives
Radical prostatectomy (RP) with or without pelvic lymph node dissection (PLND) is the most frequent approach to treat men affected by prostate cancer...
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Future directions in systemic treatment of metastatic hormone-sensitive prostate cancer
AbstractThe landscape of advanced prostate cancer treatment has evolved tremendously in past decades. The treatment paradigm has shifted from...
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In silico exploration of anti-prostate cancer compounds from differential expressed genes
Prostate cancer (PCa) is a complex and biologically diverse disease with no curative treatment options at present. This study aims to utilize...
