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Seeding activity of human superoxide dismutase 1 aggregates in familial and sporadic amyotrophic lateral sclerosis postmortem neural tissues by real-time quaking-induced conversion
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disease with average lifespan of 2–5 years after diagnosis. The...
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Translating the ALS Genetic Revolution into Therapies: A Review
Purpose of ReviewAmyotrophic lateral sclerosis (ALS) is a neurodegenerative disease causing weakness, respiratory failure, and death within 3 to...
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PP2A and GSK3 act as modifiers of FUS-ALS by modulating mitochondrial transport
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease which currently lacks effective treatments. Mutations in the RNA-binding...
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Integrative proteomics highlight presynaptic alterations and c-Jun misactivation as convergent pathomechanisms in ALS
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease mainly affecting upper and lower motoneurons. Several functionally...
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Update on ALS Treatment
Purpose of ReviewWhile amyotrophic lateral sclerosis (ALS) remains a progressive fatal diagnosis, there have been numerous advances in the last...
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Unveiling the SOD1-mediated ALS phenotype: insights from a comprehensive meta-analysis
Background and objectivesAmyotrophic lateral sclerosis associated with mutations in SOD1 ( SOD1 -ALS) might be susceptible to specific treatment. The...
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Cognitive and behavioral involvement in ALS has been known for more than a century
BackgroundAmong clinicians and researchers, it is common knowledge that, in ALS, cognitive and behavioral involvement within the spectrum of...
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Genetic analysis in Chinese patients with familial or young-onset amyotrophic lateral sclerosis
ObjectiveThe aim of our study was to investigate the genetic characteristics in patients with familial or young-onset amyotrophic lateral sclerosis...
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ALS-plus related clinical and genetic study from China
BackgroundAmyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder. An increasing number of researchers have found extra motor...
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Lifestyle and medical conditions in relation to ALS risk and progression—an introduction to the Swedish ALSrisc Study
BackgroundThis study was an introduction to the Swedish ALSrisc Study and explored the association of lifestyle and medical conditions, with risk and...
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Roadmap for C9ORF72 in Frontotemporal Dementia and Amyotrophic Lateral Sclerosis: Report on the C9ORF72 FTD/ALS Summit
A summit held March 2023 in Scottsdale, Arizona (USA) focused on the intronic hexanucleotide expansion in the C9ORF72 gene and its relevance in...
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A randomized double-blind clinical trial on safety and efficacy of tauroursodeoxycholic acid (TUDCA) as add-on treatment in patients affected by amyotrophic lateral sclerosis (ALS): the statistical analysis plan of TUDCA-ALS trial
BackgroundAmyotrophic lateral sclerosis (ALS) is a highly debilitating neurodegenerative condition. Despite recent advancements in understanding the...
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Efficacy of pain management strategies in adults with Amyotrophic Lateral Sclerosis (ALS): A Systematic Review
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive muscle weakness. Presence of pain in ALS patients is...
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Pathogenesis of Parkinson’s disease: from hints from monogenic familial PD to biomarkers
Twenty-five years have passed since the causative gene for familial Parkinson's disease (PD), Parkin (now PRKN ), was identified in 1998; PRKN is the...
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Aberrant CHCHD2-associated mitochondriopathy in Kii ALS/PDC astrocytes
Amyotrophic Lateral Sclerosis/Parkinsonism-Dementia Complex (ALS/PDC), a rare and complex neurological disorder, is predominantly observed in the...
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Clinical spreading of muscle weakness in amyotrophic lateral sclerosis (ALS): a study in 910 patients
BackgroundNeuroanatomical staging of sporadic amyotrophic lateral sclerosis (ALS) indicates that neurodegeneration may spread corticofugally.
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Factors predicting disease progression in C9ORF72 ALS patients
ObjectiveTo unveil clinical features, comorbidities, disease progression and prognostic factors in a population-based cohort of ALS patients carrying...
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The Miami Framework for ALS and related neurodegenerative disorders: an integrated view of phenotype and biology
Increasing appreciation of the phenotypic and biological overlap between amyotrophic lateral sclerosis (ALS) and frontotemporal dementia, alongside...
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Investigation of the causal relationship between ALS and autoimmune disorders: a Mendelian randomization study
BackgroundEpidemiological studies have reported an association between amyotrophic lateral sclerosis (ALS) and different autoimmune disorders. This...
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Nuclear depletion of RNA-binding protein ELAVL3 (HuC) in sporadic and familial amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis is a progressive fatal neurodegenerative disease caused by loss of motor neurons and characterized neuropathologically...
