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The feasibility of [18F]EF5-PET/CT to image hypoxia in ovarian tumors: a clinical study
RationaleEvaluation of the feasibility of [ 18 F]EF5-PET/CT scan in identifying hypoxic lesions in ovarian tumors in prospective clinical setting.
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Detection of metabolic adaptation in a triple-negative breast cancer animal model with [18F]choline-PET imaging as a surrogate for drug resistance
PurposeTest the feasibility of an image-based method to identify taxane resistance in mouse bearing triple-negative breast cancer (TNBC) tumor...
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Hypoxia PET imaging beyond 18F-FMISO in patients with high-grade glioma: 18F-FAZA and other hypoxia radiotracers
PurposeHigh-grade gliomas are aggressive primitive brain tumors presenting aberrant vasculature, regional necrosis, and areas of hypoxia. Tumor...
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Repeatability of tumour hypoxia imaging using [18F]EF5 PET/CT in head and neck cancer
PurposeHypoxia contributes to radiotherapy resistance and more aggressive behaviour of several types of cancer. This study was designed to evaluate...
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Closing the gap between 19F and 18F chemistry
Positron emission tomography (PET) has become an invaluable tool for drug discovery and diagnosis. The positron-emitting radionuclide fluorine-18 is...
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Investigation of atovaquone-induced spatial changes in tumour hypoxia assessed by hypoxia PET/CT in non-small cell lung cancer patients
BackgroundTumour hypoxia promotes an aggressive tumour phenotype and enhances resistance to anticancer treatments. Following the recent observation...
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Highlight selection of radiochemistry and radiopharmacy developments by editorial board
BackgroundThe Editorial Board of EJNMMI Radiopharmacy and Chemistry releases a biannual highlight commentary to update the readership on trends in...
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Synthesis of a 2-nitroimidazole derivative N-(4-[18F]fluorobenzyl)-2-(2-nitro-1H-imidazol-1-yl)-acetamide ([18 F]FBNA) as PET radiotracer for imaging tumor hypoxia
BackgroundTissue hypoxia is a pathological condition characterized by reducing oxygen supply. Hypoxia is a hallmark of tumor environment and is...
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Comparison of FDG and FMISO uptakes and distributions in head and neck squamous cell cancer tumors
PurposeGlycolysis is increased by hypoxia, suggesting a possible correlation between the accumulation of 2-[18F]fluoro-2-deoxy-D-glucose (FDG) in...
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Radionuclide imaging and therapy directed towards the tumor microenvironment: a multi-cancer approach for personalized medicine
Targeted radionuclide theranostics is becoming more and more prominent in clinical oncology. Currently, most nuclear medicine compounds researched...
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Hypoxic microenvironment in cancer: molecular mechanisms and therapeutic interventions
Having a hypoxic microenvironment is a common and salient feature of most solid tumors. Hypoxia has a profound effect on the biological behavior and...
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Therapeutic targeting of the hypoxic tumour microenvironment
Hypoxia is prevalent in human tumours and contributes to microenvironments that shape cancer evolution and adversely affect therapeutic outcomes....
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Positron Emission Tomography and Molecular Imaging of Head and Neck Malignancies
Purpose of ReviewMetabolic reprogramming and avid fluorodeoxyglucose (FDG) uptake in locally advanced head and neck squamous cell carcinomas and...
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Targeting hypoxic tumor microenvironment in pancreatic cancer
Attributable to its late diagnosis, early metastasis, and poor prognosis, pancreatic cancer remains one of the most lethal diseases worldwide. Unlike...
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Evaluation of repeated [18F]EF5 PET/CT scans and tumor growth rate in experimental head and neck carcinomas
BackgroundTumor hypoxia is linked to invasion and metastasis but whether this associates with tumor growth rate is not well understood. We aimed to...
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Up-regulation of autophagy is a mechanism of resistance to chemotherapy and can be inhibited by pantoprazole to increase drug sensitivity
BackgroundAutophagy is a survival mechanism that allows recycling of cellular breakdown products, particularly in stressed cells. Here we evaluate...
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Impact of hypoxia in head and neck cancer radiotherapy
BackgroundRadiotherapy plays an important role in the treatment of pharyngo-laryngeal and oral cavity head and neck squamous cell carcinoma (HNSCC)...
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Prognostic value of tumour blood flow, [18F]EF5 and [18F]FDG PET/CT imaging in patients with head and neck cancer treated with radiochemotherapy
PurposeIn order to improve the treatment of squamous cell carcinoma of the head and neck, precise information on the treated tumour’s biology is...
