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Combined evaluation of prolactin-induced peptide (PIP) and extracellular signal-regulated kinase (ERK) as new sperm biomarkers of FSH treatment efficacy in normogonadotropic idiopathic infertile men
PurposeNearly, 40% of the causes of male infertility remain idiopathic. The only suggested treatment in idiopathic oligo- and/or asthenozoospermia in...
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Extracellular signal-regulated kinases associate with and phosphorylate DHPS to promote cell proliferation
The ERK1/2 pathway is one of the most commonly dysregulated pathways in human cancers and controls many vital cellular processes. Although many...
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The role of protein kinases in diabetic neuropathic pain: an update review
ObjectivesDiabetic neuropathic pain (DNP) is a debilitating symptom of diabetic neuropathy which seriously impairs patient’s quality of life....
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The role of ERK-1 and ERK-2 gene polymorphisms in PCOS pathogenesis
BackgroundOvulation is regulated by extracellular signal-regulated kinase-1 (ERK-1) and ERK-2 signaling mechanisms, and ERK-1/2 kinases modulates the...
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IL-33 Suppresses the Progression of Atherosclerosis via the ERK1/2-IRF1-VCAM-1 Pathway
PurposeThis study was designed to explore the effects of interleukin 33 (
...IL-33) on the progression of atherosclerosis and the possible mechanism.
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G protein-coupled receptor kinases in hypertension: physiology, pathogenesis, and therapeutic targets
G protein-coupled receptors (GPCRs) mediate cellular responses to a myriad of hormones and neurotransmitters that play vital roles in the regulation...
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Wound healing effects of Asparagus lucidus Lindl extract through the phosphorylation of ERK1/2
BackgroundSkin is the outermost part of the human body and is essential in maintaining body homeostasis. In the event of skin injury, rapid wound...
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Synergistic induction of mitotic pyroptosis and tumor remission by inhibiting proteasome and WEE family kinases
Mitotic catastrophe (MC), which occurs under dysregulated mitosis, represents a fascinating tactic to specifically eradicate tumor cells. Whether...
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Minocycline and antipsychotics inhibit inflammatory responses in BV-2 microglia activated by LPS via regulating the MAPKs/ JAK-STAT signaling pathway
BackgroundAbnormal activation of microglia is involved in the pathogenesis of schizophrenia. Minocycline and antipsychotics have been reported to be...
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3-Hydroxybutyrate ameliorates insulin resistance by inhibiting PPARγ Ser273 phosphorylation in type 2 diabetic mice
3-Hydroxybutyrate (3HB) is a small ketone body molecule produced endogenously by the body in the liver. Previous studies have shown that 3HB can...
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Interaction of microRNAs with sphingosine kinases, sphingosine-1 phosphate, and sphingosine-1 phosphate receptors in cancer
Sphingosine-1-phosphate (S1P), a pleiotropic lipid mediator, participates in various cellular processes during tumorigenesis, including cell...
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Extracellular vesicles as tools and targets in therapy for diseases
Extracellular vesicles (EVs) are nano-sized, membranous structures secreted into the extracellular space. They exhibit diverse sizes, contents, and...
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Sphingosine-1-Phosphate Protects Against the Development of Cardiac Remodeling via Sphingosine Kinase 2 and the S1PR2/ERK Pathway
ObjectiveCardiac remodeling is a common pathological change in various cardiovascular diseases and can ultimately result in heart failure. Thus,...
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Thrombospondin 1 and Reelin act through Vldlr to regulate cardiac growth and repair
Adult mammalian cardiomyocytes have minimal cell cycle capacity, which leads to poor regeneration after cardiac injury such as myocardial infarction....
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EML4-ALK fusion protein in Lung cancer cells enhances venous thrombogenicity through the pERK1/2-AP-1-tissue factor axis
BackgroundAccumulating evidence links the echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) rearrangement to...
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Extracellular matrix-derived mechanical force governs breast cancer cell stemness and quiescence transition through integrin-DDR signaling
The extracellular matrix (ECM) serves as signals that regulate specific cell states in tumor tissues. Increasing evidence suggests that extracellular...
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Nasal irrigation with licorice extract (Glycyrrhiza glabra) in treating nasal polyps by reducing fibroblast differentiation and extracellular matrix production in TGF-β1-stimulated nasal polyp-derived fibroblasts by inhibiting the MAPK/ERK-1/2 pathway – an in vitro and in clinic study
BackgroundTo date, treating nasal polyps (NPs) is still a medical challenge. However, we have developed an innovative therapy using licorice extract...
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Inhibition of p38 mitogen-activated protein kinases may attenuate scar proliferation after cleft lip surgery in rabbits via Smads signaling pathway
BackgroundCleft lip repair surgery always results in visible scarring. It has been proved that scar formation can be reduced by inhibiting the p38...
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The effect of neutrophil extracellular traps in venous thrombosis
Neutrophil extracellular traps (NETs) as special release products of neutrophils have received extensive attention. They are composed of decondensed...
