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Central nervous system embryonal tumor with PLAGL1 amplification: a case report of a novel entity focusing on imaging findings
The embryonal central nervous system (CNS) tumor with PLAGL1 (pleomorphic adenoma gene-like) amplification is a novel type of pediatric neoplasm with...
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BCOR Positive Central Nervous System Neuroepithelial Tumor Masquerading as a Meningioma
The central nervous system tumor with BCL-6 interacting corepressor internal tandem duplication (BCOR-ITD) is a molecularly defined entity with an...
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Central nervous system embryonal tumors with EWSR1-PLAGL1 rearrangements reclassified as INI-1 deficient tumors at relapse
PurposeCentral nervous system (CNS) embryonal tumors are a diverse group of malignant tumors typically affecting pediatric patients that recently...
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Transcallosal and endoscopic hybrid approach to a rare entity of pediatric intraventricular tumors—cribriform neuroepithelial tumor: a case report and literature review
PurposeCribriform neuroepithelial tumor (CRINET) is a provisional category of intraventricular tumors, sharing similarities with AT/RTs, and there is...
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Amplification of the PLAG-family genes—PLAGL1 and PLAGL2—is a key feature of the novel tumor type CNS embryonal tumor with PLAGL amplification
Pediatric central nervous system (CNS) tumors represent the most common cause of cancer-related death in children aged 0–14 years. They differ from...
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Medulloblastomas, CNS embryonal tumors, and cerebellar mutism syndrome: advances in care and future directions
Central nervous system (CNS) embryonal tumors, commonly found in pediatric patients, represent a heterogeneous mix of lesions with an overall poor...
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Pediatric-type high-grade neuroepithelial tumors with CIC gene fusion share a common DNA methylation signature
Pediatric neoplasms in the central nervous system (CNS) show extensive clinical and molecular heterogeneity and are fundamentally different from...
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Molecular classification and outcome of children with rare CNS embryonal tumors: results from St. Jude Children’s Research Hospital including the multi-center SJYC07 and SJMB03 clinical trials
Methylation profiling has radically transformed our understanding of tumors previously called central nervous system primitive neuro-ectodermal...
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The spectrum of morphological findings in pediatric central nervous system MN1-fusion-positive neuroepithelial tumors
PurposeCentral nervous system high-grade neuroepithelial tumor with MN1 alteration (CNS-HGNET- MN1 ) is a rare entity defined by its DNA methylation...
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An atypical location of pineoblastoma RB1 subgroup without pineal or retinal tumor
PurposeTo describe the clinical and imaging features of a sellar-suprasellar pineoblastoma RB1 subgroup without pineal or retinal involvement.
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A pediatric cerebral tumor with MN1 alteration and pathological features mimicking carcinoma metastasis: may the terminology “high grade neuroepithelial tumor with MN1 alteration” still be relevant?
IntroductionAstroblastoma, MN1 -altered (old name: high-grade neuroepithelial tumor/HGNET with MN1 alteration) is a recently described central...
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PATZ1 fusions define a novel molecularly distinct neuroepithelial tumor entity with a broad histological spectrum
Large-scale molecular profiling studies in recent years have shown that central nervous system (CNS) tumors display a much greater heterogeneity in...
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Central nervous system high grade neuroepithelial tumor with BCOR immunopositivity: Is there a molecular heterogeneity?
Central nervous system high grade neuroepithelial tumor – BCOR altered is a newly defined entity which is characterised by internal tandem...
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The global prevalence of primary central nervous system tumors: a systematic review and meta-analysis
BackgroundPrimary central nervous system (CNS) tumors are a heterogeneous group of neoplasms, including benign and malignant tumors. Since there are...
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Pineal anlage tumor: clinical and diagnostic features, and rationales for treatment
PurposeTo provide a treatment-focused review and develop basic treatment guidelines for patients diagnosed with pineal anlage tumor (PAT).
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Germ cell tumors with neuroglial differentiation do not show molecular features akin to their central nervous system counterpart: experience from extra-gynecological sites
Teratomas with secondary somatic malignancy showing neuroglial differentiation (central nervous system (CNS)-type tumors) arising from a glial or...
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Early ependymal tumor with MN1-BEND2 fusion: a mostly cerebral tumor of female children with a good prognosis that is distinct from classical astroblastoma
PurposeReview of the clinicopathologic and genetic features of early ependymal tumor with MN1-BEND2 fusion (EET MN1-BEND2), classical...
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Contributional role of susceptibility-weighted imaging and apparent diffusion coefficient in pediatric brain tumor grading
BackgroundCentral nervous system neoplasms are a primary cause of mortality and one of the most frequent solid tumors in children. Magnetic resonance...
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Recurrent fusions in PLAGL1 define a distinct subset of pediatric-type supratentorial neuroepithelial tumors
Ependymomas encompass a heterogeneous group of central nervous system (CNS) neoplasms that occur along the entire neuroaxis. In recent years,...
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Virtual multi-institutional tumor board: a strategy for personalized diagnoses and management of rare CNS tumors
PurposeMultidisciplinary tumor boards (MTBs) integrate clinical, molecular, and radiological information and facilitate coordination of...