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De la dysfonction du tissu adipeux blanc aux phénotypes anatomocliniques de l’obésité
The adverse metabolic consequences of obesity are less related to increased fat mass than to impaired metabolic flexibility of adipose tissue (AT),...
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Adiposité, hypoxie et apnées du sommeil : de l’obésité au syndrome métabolique
Obesity is a major risk factor for cardio-metabolic events. Obesity is linked to adipocyte dysfunction of which hypoxia is one of the main effectors....
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Stéatose et résistance à l’insuline : implication des hépatokines
Steatosed liver, in obesity and insulin resistance, undergoes metabolic alterations but also in its secretome. The concept of hepatokines has been...
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SHP2 : une cible potentielle d’intérêt dans l’obésité et ses complications métaboliques ?
SHP2 is a ubiquitous protein belonging to the evolutionary-conserved protein tyrosine phosphatases (PTP) family. Data accumulated since its discovery...
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Intérêt de la phase postprandiale pour la santé de l’Homme
Humans now spend more than three quarters of their life in postprandial state. Although the link between cardio-metabolic diseases and fasting...
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Histologie du tissu adipeux blanc normal et pathologique
White adipose tissue is composed of mature adipocytes, precursors (preadipocytes), endothelial cells, macrophages and other immune cells. The...
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Estimer la sensibilité à l’insuline : trop d’outils tuent-ils l’outil ?
A lot of surrogate indexes are currently available to assess insulin sensitivity/resistance in human. Various index derived from insulin and glucose...
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Boissons sucrées et obésité: aspects épidémiologiques et physiopathologiques
Consumption of sugar-sweetened beverages (SSB) has markedly increased over the past decades, and several authors have suggested that such increase...
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Origine développementale des adipocytes
The current epidemic of obesity and overweight has caused a surge of interest in the study of adipose tissue formation. Much progress has been made...
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Obésité de la personne âgée: définition, phénotypes, épidémiologie et conséquences pour la santé
It is difficult to define what is meant by the term obesity in elderly persons (EPs), as aging is associated with increased body fat and reduced lean...
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Consommation de fructose: facteur déclenchant du syndrome métabolique ?
Fructose is a simple sugar, whose consumption has increased over the past decades, mainly due to an increased consumption of soft drinks and other...