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Pregabalin for Recurrent Seizures in Critical Illness: A Promising Adjunctive Therapy, Especially for cyclic Seizures
BackgroundPregabalin (PGB) is an effective adjunctive treatment for focal epilepsy and acts by binding to the alpha2-delta subunit of voltage-gated...
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Rescue Medications for Acute Repetitive Seizures
Purpose of reviewThis article reviews the current evidence-based treatments for the management of acute repetitive seizures (ARS).
Recent findings ... -
Biomolecular mechanisms of epileptic seizures and epilepsy: a review
Epilepsy is a recurring neurological disease caused by the abnormal electrical activity in the brain. This disease has caused about 50 new cases in...
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The Relationship Between Seizures and Spreading Depolarizations in Patients with Severe Traumatic Brain Injury
BackgroundBoth seizures and spreading depolarizations (SDs) are commonly detected using electrocorticography (ECoG) after severe traumatic brain...
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Prevalence of Undiagnosed Acute Hepatic Porphyria in Cyclic Vomiting Syndrome and Overlap in Clinical Symptoms
Background and AimsAcute hepatic porphyria (AHP) presents with nausea and vomiting and can mimic cyclic vomiting syndrome (CVS). The prevalence of...
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Pharmacotherapy for Nonconvulsive Seizures and Nonconvulsive Status Epilepticus
Most seizures in critically ill patients are nonconvulsive. A significant number of neurological and medical conditions can be complicated by...
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Electrographic monitoring for seizure detection in the neonatal unit: current status and future direction
AbstractNeonatal neurocritical intensive care is dedicated to safeguarding the newborn brain by prioritising clinical practices that promote early...
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Radiological insights into rheumatoid meningitis – a rare central nervous system manifestation of rheumatoid arthritis: a retrospective review of six cases
BackgroundThe objective is to analyze and review the clinical, laboratory, and neuroimaging characteristics of rheumatoid meningitis (RM) in six...
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Genetic exploration of Dravet syndrome: two case report
BackgroundDravet syndrome is an infantile-onset developmental and epileptic encephalopathy (DEE) characterized by drug resistance, intractable...
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Therapeutic efficacy of voltage-gated sodium channel inhibitors in epilepsy
Epilepsy is a neurological disease characterized by excessive and abnormal hyper-synchrony of electrical discharges of the brain and a predisposition...
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Efficacy of contralaterally controlled functional electrical stimulation compared to cyclic neuromuscular electrical stimulation and task-oriented training for recovery of hand function after stroke: study protocol for a multi-site randomized controlled trial
BackgroundMulti-site studies in stroke rehabilitation are important for determining whether a technology and/or treatment can be successfully...
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Rhythmic movements in sleep disorders and in epileptic seizures during sleep
Rhythmic movements during sleep may occur in the context of physiological sleep-related motor activity or be part of sleep-related movement disorders...
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Expanding the clinical spectrum of cytosolic phosphoenolpyruvate carboxykinase deficiency: novel PCK1 variants in four Arabian Gulf families
BackgroundIn metabolic stress, the cytosolic phosphoenolpyruvate carboxykinase (PEPCK-C) enzyme is involved in energy production through the...
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The Interaction Between Sleep and Epilepsy
Purpose of ReviewTo review the mutual interactions between sleep and epilepsy, including mechanisms of epileptogenesis, the relationship between...
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Channelopathies in epilepsy: an overview of clinical presentations, pathogenic mechanisms, and therapeutic insights
Pathogenic variants in genes encoding ion channels are causal for various pediatric and adult neurological conditions. In particular, several...
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Delay in diagnosing a patient with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome who presented with status epilepticus and lactic acidosis: a case report
BackgroundMitochondrial encephalomyopathy, lactic acidosis, and stroke-like episode syndrome is a rare mitochondrial genetic disorder that can...
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Epilepsy and epileptiform activity in late-onset Alzheimer disease: clinical and pathophysiological advances, gaps and conundrums
A growing body of evidence has demonstrated a link between Alzheimer disease (AD) and epilepsy. Late-onset epilepsy and epileptiform activity can...
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Comparison of the effectiveness of anterior thalamic stimulation in a European registry and a phase III study—English version
BackgroundBesides the data of the phase III study (SANTE), the results of the MORE registry on the use of anterior thalamic deep brain stimulation...
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Gene variations of glutamate metabolism pathway and epilepsy
BackgroundEpilepsy is a paroxysmal disorder of the brain, caused by an imbalance of neuronal excitation and inhibition. Glutamate is the most...
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Branched-Chain Amino Acids and Seizures: A Systematic Review of the Literature
BackgroundUp to 40% of patients with epilepsy experience seizures despite treatment with antiepileptic drugs; however, branched-chain amino acid...
