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Prognostic factors for surgically managed intramedullary spinal cord tumours: a single-centre case series
PurposeIntramedullary spinal cord tumours (IMSCTs) are comparatively rare neoplasms. We present a single-centre clinical case series of adult...
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The effectiveness and safety of proton beam radiation therapy in children and young adults with Central Nervous System (CNS) tumours: a systematic review
BackgroundCentral nervous system (CNS) tumours account for around 25% of childhood neoplasms. With multi-modal therapy, 5-year survival is at around...
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Intramedullary spinal cord and filum tumours—long-term outcome: single institution case series
BackgroundIntramedullary spinal cord tumours are rare and account for about 2–4% of primary CNS tumours. Ependymomas and astrocytomas are most...
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Aggressive pituitary tumours and pituitary carcinomas
Although usually benign, anterior pituitary tumours occasionally exhibit aggressive behaviour, with invasion of surrounding tissues, rapid growth,...
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Alternating Facial Palsy- Decoding the Enigma
Facial palsy is a neurological emergency with a wide spectrum of aetiologies. The term ‘alternating facial palsy’, a very rare presentation, refers...
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Mutation in Chek2 triggers von Hippel-Lindau hemangioblastoma growth
PurposeVon Hippel-Lindau (VHL) is a rare inherited disease mainly characterized by the growth of tumours, predominantly hemangioblastomas (Hbs) in...
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Recommendations of the Spanish brachytherapy group of the Spanish Society of Radiation Oncology and the Spanish Society of Medical Physics for interstitial high-dose-rate brachytherapy for gynaecologic malignancies
The present document includes consensus-based recommendations from the Brachytherapy Group (GEB) of the Spanish Society of Radiation Oncology (SEOR)...
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SEC31A may be associated with pituitary hormone deficiency and gonadal dysgenesis
PurposeDisorders/differences of sex development (DSD) result from variants in many different human genes but, frequently, have no detectable...
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Pineal cysts in children: a paediatric series treated over the last twenty years in Lyon
BackgroundPineal cysts are a rare lesion of the pineal gland. Pineal cysts are benign lesions, generally asymptomatic, and are usually an incidental...
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Effectiveness of manual therapy, computerised mobilisation plus home exercise, and home exercise only in treating work-related neck pain: study protocol for a randomised controlled trial
BackgroundWork-related neck pain (WRNP) is a leading cause of disability and absenteeism. Patients with neck pain often have neck muscle tenderness...
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Primary intracranial sarcoma masquerading as a chronic subdural haematoma: illustrative case and review of an unusual phenomenon
It is very unusual for a primary intracranial malignancy to present as a chronic subdural hematoma. This case report describes one such case in a...
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Molecular characterisation defines clinically-actionable heterogeneity within Group 4 medulloblastoma and improves disease risk-stratification
Group 4 tumours (MB Grp4 ) represent the majority of non-WNT/non-SHH medulloblastomas. Their clinical course is poorly predicted by current...
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Paediatric hydrocephalus
Hydrocephalus is classically considered as a failure of cerebrospinal fluid (CSF) homeostasis that results in the active expansion of the cerebral...
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Diffusion tensor imaging indices as biomarkers for cognitive changes following paediatric radiotherapy: a systematic review and meta-analysis
Diffusion tensor imaging (DTI) can detect subtle manifestations of white matter (WM) injury following paediatric radiotherapy, which may be...
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Tuberculosis revisted: classic imaging findings in childhood
Tuberculosis (TB) remains one of the major public health threats worldwide, despite improved diagnostic and therapeutic methods. Tuberculosis is one...
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Diagnosis and treatment of Chiari malformation and syringomyelia in adults: international consensus document
BackgroundSyringomyelia and Chiari malformation are classified as rare diseases on Orphanet, but international guidelines on diagnostic criteria and...
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Medulloblastoma
Medulloblastoma (MB) comprises a biologically heterogeneous group of embryonal tumours of the cerebellum. Four subgroups of MB have been described...
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