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Anti-HSP70 alleviates cell migration and proliferation in colorectal cancer cells (CRC) by targeting CXCR4 (in vitro study)
Colorectal cancer (CRC), the third most common cancer in men and women, accounts for 8% of new cancer cases in the US and 8 to 9% of the nation’s...
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Effectiveness and implementation of mPATH™-CRC: a mobile health system for colorectal cancer screening
BackgroundScreening for colorectal cancer (CRC) is widely recommended but underused, even though CRC is the third most diagnosed cancer and the...
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CircCOL1A1 promotes proliferation, migration, and invasion of colorectal cancer (CRC) cells and glutamine metabolism through GLS1 up-regulation by sponging miR-214-3p
BackgroundCircular ribose nucleic acids (circRNAs), an abundant type of noncoding RNAs, are widely expressed in eukaryotic cells and exert a...
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TRIM59 guards ER proteostasis and prevents Bortezomib-mediated colorectal cancer (CRC) cells’ killing
The endoplasmic reticulum (ER) is a critical organelle that preserves the protein homeostasis of cells. Under various stress conditions, cells evolve...
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Prediction model of colorectal cancer (CRC) lymph node metastasis based on intestinal bacteria
BackgroundLymph node metastasis is the main metastatic mode of CRC. Lymph node metastasis affects patient prognosis.
ObjectiveTo screen differential...
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PARs in the inflammation-cancer transformation of CRC
Colorectal cancer (CRC) is one of the common malignancies with a global trend of increasing incidence and mortality. There is an urgent need to...
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Mechanisms of metastatic colorectal cancer
Despite extensive research and improvements in understanding colorectal cancer (CRC), its metastatic form continues to pose a substantial challenge,...
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Colorectal cancer pre-diagnostic symptoms are associated with anatomic cancer site
BackgroundSigns and red flag symptoms in colorectal cancer (CRC) patients who are below the recommended screening age are often overlooked, leading...
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Naringin Inhibits Colorectal Carcinogenesis by Inhibiting Viability of Colorectal Cancer Cells
ObjectiveTo explore the therapeutic effect of naringin on colorectal cancer (CRC) and the related mechanism.
MethodsCell counting kit-8 (CCK-8)...
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Four microRNA gene polymorphisms are associated with Iraqi patients with colorectal cancer
BackgroundColorectal cancer (CRC) is a major cause to global cancer-related mortality. The development of colorectal cancer is linked to hereditary...
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Risk factors for metachronous colorectal cancer and advanced neoplasia following primary colorectal cancer: a systematic review and meta-analysis
BackgroundIdentifying risk factors for metachronous colorectal cancer (CRC) and metachronous advanced neoplasia could be useful for guiding...
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Young-onset colorectal cancer
In the past decades the incidence of colorectal cancer (CRC) in people under the age of 50 years has increased, which is referred to as early-onset...
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16S rRNA sequencing analysis of the oral and fecal microbiota in colorectal cancer positives versus colorectal cancer negatives in Iranian population
BackgroundColorectal cancer (CRC) poses a significant healthcare challenge, accounting for nearly 6.1% of global cancer cases. Early detection,...
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Immunogenic cell death in colorectal cancer: a review of mechanisms and clinical utility
Colorectal cancer (CRC) is a major cause of cancer-related morbidity and mortality worldwide. Despite several clinical advances the survival of...
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Enhancing colorectal cancer prevention: a national assessment of public awareness in Egypt
BackgroundDespite the increasing incidence of colorectal cancer (CRC) in the Egyptian population, it still seems that there is a significant lack of...
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HOTAIR in colorectal cancer: structure, function, and therapeutic potential
lncRNAs play a vital part in cancer development by regulating gene expression. Among these, the lncRNA HOTAIR has gained considerable attention due...
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ESR Essentials: Imaging in colorectal cancer—practice recommendations by ESGAR
AbstractColorectal cancer (CRC) is a significant global health concern. Diagnostic imaging, using different modalities, has a pivotal role in CRC,...
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The tumor immune microenvironment and T-cell-related immunotherapies in colorectal cancer
The tumor microenvironment includes a complex network of immune T-cell subsets that play important roles in colorectal cancer (CRC) progression and...
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Reduction in colorectal cancer incidence by screening endoscopy
Colorectal cancer (CRC) incidence rates decreased by up to 50% in older age groups in the USA in the era of the widespread uptake of screening...
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Review of Animal Models of Colorectal Cancer in Different Carcinogenesis Pathways
Colorectal cancer (CRC) is a common malignant tumor of the gastrointestinal tract with increasing morbidity and mortality. Exploring the factors...