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Challenges regarding informed consent in recruitment to clinical research: a qualitative study of clinical research nurses’ experiences
BackgroundClinical research nurses (CRNs) have first-hand experience with ethical challenges and play a crucial role in upholding ethical conduct and...
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The challenges of assessing adiposity in a clinical setting
To tackle the burden of obesity-induced cardiometabolic disease, the scientific community relies on accurate and reproducible adiposity measurements...
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Challenges and prospects of visual contactless physiological monitoring in clinical study
The monitoring of physiological parameters is a crucial topic in promoting human health and an indispensable approach for assessing physiological...
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NIR-II light in clinical oncology: opportunities and challenges
Novel strategies utilizing light in the second near-infrared region (NIR-II; 900–1,880 nm wavelengths) offer the potential to visualize and treat...
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Gene therapy: principles, challenges and use in clinical practice
IntroductionGene therapy is an emerging topic in medicine. The first products have already been licensed in the European Union for the treatment of...
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Direct Oral Anticoagulants: Navigating Through Clinical Challenges
PurposeDirect oral anticoagulants (DOACs) have been approved, for over a decade, by both European and American medicine agencies, for treatment and...
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Challenges in Conducting Clinical Trials for Preeclampsia
Purpose of ReviewTo review recent data describing the challenges and innovations in therapeutic research focused on the prevention and treatment of...
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Experiences and challenges with the new European Clinical Trials Regulation
BackgroundThe new European Medicines Agency (EMA) Clinical Trials Information System (CTIS), based on the Clinical Trials Regulation (CTR EU...
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Challenges of implementing computer-aided diagnostic models for neuroimages in a clinical setting
Advances in artificial intelligence have cultivated a strong interest in develo** and validating the clinical utilities of computer-aided...
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Non-COVID-19 UK clinical trials and the COVID-19 pandemic: impact, challenges and possible solutions
IntroductionThe COVID-19 pandemic impacted the operationalisation of non-COVID-19 clinical trials globally, particularly site and participant...
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Challenges in integrating molecular profiles into clinical cancer care
Profiling of malignancies with next-generation sequencing (NGS) is now routine in clinical practice. While many cases of approved targeted therapies...
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Clinical and Scientific Challenges to Effectiveness Studies Under Coverage with Evidence Development in Alzheimer’s Disease
The Centers for Medicare and Medicaid Services (CMS) has recently issued a national coverage determination for US Food and Drug Administration...
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Gene therapy for primary mitochondrial diseases: experimental advances and clinical challenges
The variable clinical and biochemical manifestations of primary mitochondrial diseases (PMDs), and the complexity of mitochondrial genetics, have...
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An Update on the Clinical Status, Challenges, and Future Directions of Oncolytic Virotherapy for Malignant Gliomas
Malignant gliomas are common central nervous system tumors that pose a significant clinical challenge due to the lack of effective treatments....
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Clinical Assessment of Osteoarthritis Pain: Contemporary Scenario, Challenges, and Future Perspectives
The multifaceted nature of osteoarthritis (OA) pain presents a challenge in understanding and managing the condition. The diverse pain experiences,...
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Targeting NEDD8-activating enzyme for cancer therapy: developments, clinical trials, challenges and future research directions
NEDDylation, a post-translational modification through three-step enzymatic cascades, plays crucial roles in the regulation of diverse biological...
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Implementation challenges and lessons learned from the STREAM clinical trial—a survey of trial sites
BackgroundDesign and implementation of multi-country clinical trials for multidrug-resistant tuberculosis (MDR-TB) are complex for several reasons,...
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Clinical profile and challenges faced in the management of optic neuritis: the Indian scenario
PurposeOptic neuritis (ON) is a relatively common ophthalmic disease that has recently received renewed attention owing to immunological...
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Gastroenteropancreatic neuroendocrine neoplasms: current development, challenges, and clinical perspectives
Neuroendocrine neoplasms (NENs) are highly heterogeneous and potentially malignant tumors arising from secretory cells of the neuroendocrine system....
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Examining the clinical and radiological landscape of rhupus: navigating the challenges in disease classification
Rhupus, in the broad sense, refers to an overlap between rheumatoid arthritis (RA) and lupus. However, there is a paucity of data on the appropriate...
