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**oglican Cream in Italian Patients with Chronic Venous Disease: A Post-Marketing Study Investigating Effects on Clinical and Cutaneous Signs and Symptoms
IntroductionThe progression of chronic venous disease (CVD) is characterized by edema of the legs and/or venous ulcers of the lower limbs in...
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Prevalence of clinical signs, symptoms and comorbidities at diagnosis of acromegaly: a systematic review in accordance with PRISMA guidelines
ObjectiveDiagnostic delay is high in acromegaly and leads to increased morbidity and mortality. The aim of this study is to systematically assess the...
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Impact of signs and symptoms on the prognosis of patients with HFmrEF
BackgroundWorsening of heart failure (HF) symptoms is the leading cause of medical contact and hospitalization of patients with mildly reduced...
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Symptoms and signs did not predict outcome after surgery: a prospective study of 143 patients with idiopathic normal pressure hydrocephalus
ObjectiveTo determine the utility of symptoms, signs, comorbidities and background variables for the prediction of outcome of treatment in iNPH.
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Clinical and kinematic characterization of parkinsonian soft signs in essential tremor
BackgroundSubtle parkinsonian signs, i.e., rest tremor and bradykinesia, are considered soft signs for defining essential tremor (ET) plus.
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Patient Experience of Lichen Planus: A Qualitative Exploration of Signs, Symptoms, and Health-Related Quality of Life Impacts
IntroductionLichen planus (LP) is an inflammatory skin disorder that can present in various forms across the body, including lesions on the skin...
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Symptoms and signs of urogenital cancer in primary care
BackgroundUrogenital cancers are common, accounting for approximately 20% of cancer incidence globally. Cancers belonging to the same organ system...
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Effectiveness of full Pulpotomy compared with Root canal treatment in managing teeth with signs and symptOms indicative of irreversible pulpitis: a protocol for prospectiVE meta-analysis of individual participant data of linked randomised clinical trials (PROVE)
BackgroundFull pulpotomy has been proposed as an alternative to root canal treatment in teeth with signs and symptoms indicative of irreversible...
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Performance of clinical signs and symptoms, rapid and reference laboratory diagnostic tests for diagnosis of human African trypanosomiasis by passive screening in Guinea: a prospective diagnostic accuracy study
BackgroundPassive diagnosis of human African trypanosomiasis (HAT) at the health facility level is a major component of HAT control in Guinea. We...
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Cervical and ocular vestibular-evoked myogenic potentials test results and its relation to vestibular signs and symptoms in individuals with vestibular migraine
ObjectiveThe objective of the present study was to characterize the response rate, latency, and amplitude parameters of the cervical and ocular...
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Development of patient- and observer-reported outcome measures to assess COVID-19 signs and symptoms in children and adolescents
BackgroundThe Symptoms of Infection with Coronavirus-19 (SIC) is a 30-item patient-reported outcome measure to evaluate the presence and severity of...
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Lebrikizumab Provides Rapid Clinical Responses Across All Eczema Area and Severity Index Body Regions and Clinical Signs in Adolescents and Adults with Moderate-to-Severe Atopic Dermatitis
IntroductionAtopic dermatitis (AD) affects multiple areas of the body, some of which may be more refractory to treatment. We evaluated improvements...
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Optimizing Signal Management in a Vaccine Adverse Event Reporting System: A Proof-of-Concept with COVID-19 Vaccines Using Signs, Symptoms, and Natural Language Processing
IntroductionThe Vaccine Adverse Event Reporting System (VAERS) has already been challenged by an extreme increase in the number of individual case...
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Development of an Item Bank to Assess Patient-Reported Outcomes: Signs, Symptoms, and Impacts of COVID-19
Background and ObjectivePatients experience a wide range of signs, symptoms, and impacts related to coronavirus disease 2019 (COVID-19). A...
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Analysis of Meibomian Glands in Juvenile Systemic Lupus Erythematosus Patients without Dry Eye Symptoms and Signs
PurposeTo evaluate meibomian gland loss and its possible association with disease duration and activity in Juvenile Systemic Lupus Erythematosus...
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The yield of chest X-ray or ultra-low-dose chest-CT in emergency department patients suspected of pulmonary infection without respiratory symptoms or signs
ObjectiveThe yield of pulmonary imaging in patients with suspected infection but no respiratory symptoms or signs is probably limited, ultra-low-dose...
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Development of a novel patient-reported outcome measure to assess signs and symptoms of COVID-19
BackgroundGiven the urgent need for vaccines and treatments for coronavirus disease 2019 (COVID-19), the Symptoms of Infection with Coronavirus-19...
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Applications of topical immunomodulators enhance clinical signs of vernal keratoconjunctivitis (VKC) and atopic keratoconjunctivitis (AKC): a meta-analysis
PurposeThis meta-analysis aimed to review the safety and efficacy of topical cyclosporine A (CsA) and topical tacrolimus in allergic eye disease.
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Dupilumab Demonstrates Rapid Onset of Action in Improving Signs, Symptoms and Quality of Life in Adults with Atopic Dermatitis
IntroductionDupilumab has significantly improved the signs, symptoms and quality of life (QoL) of patients with moderate-to-severe atopic dermatitis...
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Non-fatal strangulation and COVID-19 common symptoms and signs: considerations for medical and forensic assessment
Emerging evidence suggests that an onset or escalation of interpersonal violence has been occurring during the COVID-19 pandemic, particularly among...
