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Predictive value of the systemic immune inflammation index and systemic inflammatory response index on omalizumab drug survival in chronic spontaneous urticaria
BackgroundOmalizumab is recommended as adjunctive therapy for antihistamine-refractory chronic spontaneous urticaria (CSU). However, its long-term...
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Inflammatory biotype of ADHD is linked to chronic stress: a data-driven analysis of the inflammatory proteome
The association between Attention Deficit Hyperactivity Disorder (ADHD) and low-grade inflammation has been explored in children but rarely in...
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Higher inflammatory response in hepatocellular carcinoma is associated with immune cell infiltration and a better outcome
Background and aimsHepatocellular carcinoma (HCC) often develops from chronic liver inflammation. Inflammation within a tumor can either promote...
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Inflammatory cytokine levels and changes during omalizumab treatment in chronic spontaneous urticaria
While several studies have examined the role of T cells and related cytokines in the development of chronic spontaneous urticaria (CSU), there is a...
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Vaginal Bacteria Elicit Acute Inflammatory Response in Fallopian Tube Organoids
To facilitate in vitro mechanistic studies in pelvic inflammatory disease and subsequent tubal factor infertility, we sought to establish patient...
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Systemic inflammatory response index as an independent predictor of severity in patients with obstructive sleep apnea
BackgroundChronic inflammation plays a crucial role in develo** various cardiovascular and metabolic disorders. Obstructive sleep apnea (OSA) is a...
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Cutaneous neuropeptides: the missing link between psychological stress and chronic inflammatory skin disease?
A “brain-skin” connection has been long been observed between chronic stress and chronic inflammatory skin disease including urticaria, psoriasis,...
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Traumatic inflammatory response: pathophysiological role and clinical value of cytokines
Severe trauma is an intractable problem in healthcare. Patients have a widespread immune system response that is complex and vital to survival....
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Specific inflammatory osteoclast precursors induced during chronic inflammation give rise to highly active osteoclasts associated with inflammatory bone loss
Elevated osteoclast (OC) activity is a major contributor to inflammatory bone loss (IBL) during chronic inflammatory diseases. However, the specific...
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Anti-neurofascin-155 antibody mediated a distinct phenotype of chronic inflammatory demyelinating polyradiculoneuropathy
BackgroundTo investigate Ranvier’s autoantibodies prevalence and isotypes in various peripheral neuropathy variants, compare clinical features...
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Prognostic value of the systemic inflammatory index (SII) and systemic inflammatory response index (SIRI) in patients with traumatic spinal cord injury
PurposeThe overwhelming inflammatory response plays a critical role in the secondary injury cascade of traumatic spinal cord injury (tSCI). The...
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Impact of minimal invasive extracorporeal circulation on systemic inflammatory response – a randomized trial
BackgroundExtracorporeal circulation causes a systemic inflammatory response, that may cause postoperative haemodynamic instability and end-organ...
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How I Treat Chronic Inflammatory Demyelinating Polyneuropathy Podcast
Chronic inflammatory demyelinating polyneuropathy (CIDP) is an acquired immune-mediated neuropathy that typically presents with progressive or...
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Chronic kidney disease activates the HDAC6-inflammatory axis in the heart and contributes to myocardial remodeling in mice: inhibition of HDAC6 alleviates chronic kidney disease-induced myocardial remodeling
Chronic kidney disease (CKD) adversely affects the heart. The underlying mechanism and the interplay between the kidney and the heart are still...
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Nerve ultrasound may help predicting response to immune treatment in chronic inflammatory demyelinating polyradiculoneuropathy
BackgroundsNerve ultrasound has been proven to be an accurate tool in diagnosing chronic inflammatory demyelinating polyradiculoneuropathy (CIDP)....
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Gentiopicroside ameliorates the lipopolysaccharide-induced inflammatory response and hypertrophy in chondrocytes
PurposeThis study aimed to evaluate the protective effects of gentiopicroside against lipopolysaccharide-induced chondrocyte inflammation.
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Autonomic nervous system involvement in chronic inflammatory demyelinating polyradiculoneuropathy: a literature review
Background and aimsAlthough dysautonomia is a well-recognized complication of acute demyelinating polyradiculoneuropathy, it is rarely reported and...
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Immune cell signatures and inflammatory mediators: unraveling their genetic impact on chronic kidney disease through Mendelian randomization
Prior research has established associations between immune cells, inflammatory proteins, and chronic kidney disease (CKD). Our Mendelian...
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MicroRNA-223-3p downregulates the inflammatory response in preeclampsia placenta via targeting NLRP3
ObjectiveTo investigate the regulatory role of miR-223-3p in the inflammatory response of PE placenta.
MethodsPE and normal placental tissues were...
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Mutant LRRK2 exacerbates immune response and neurodegeneration in a chronic model of experimental colitis
The link between the gut and the brain in Parkinson’s disease (PD) pathogenesis is currently a subject of intense research. Indeed, gastrointestinal...
