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The significance of thymoquinone administration on liver toxicity of diazinon and cholinesterase activity; a recommendation for prophylaxis among individuals at risk
BackgroundDiazinon (DZN), a widely used chemical herbicide for controlling agricultural pests, is an important organophosphorus pesticide and an...
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Effect of black cumin-enriched acha-based cookies on antioxidant status and cholinergic enzymes in the brain of Plasmodium berghei-infected diabetic mice
The pharmacological significance of acha ( Digitaria exilis ) and black cumin ( Nigella sativa ) in fostering sound mental health has been demonstrated...
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Perioperative point-of-care-testing of plasmacholinesterases identifies older patients at risk for postoperative delirium: an observational prospective cohort study
BackgroundPostoperative delirium (POD) is a severe perioperative complication that may increase mortality and length-of-stay in older patients....
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The synapse as a treatment avenue for Alzheimer’s Disease
Alzheimer’s disease (AD) is a neurodegenerative disorder with devastating symptoms, including memory impairments and cognitive deficits. Hallmarks of...
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Insight into antioxidant-like activity and computational exploration of identified bioactive compounds in Talinum triangulare (Jacq.) aqueous extract as potential cholinesterase inhibitors
BackgroundRecent reports have highlighted the significance of plant bioactive components in drug development targeting neurodegenerative disorders...
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Targeting Biometals in Alzheimer’s Disease with Metal Chelating Agents Including Coumarin Derivatives
Numerous physiological processes happening in the human body, including cerebral development and function, require the participation of biometal ions...
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Antioxidant evaluation and computational prediction of prospective drug-like compounds from polyphenolic-rich extract of Hibiscus cannabinus L. seed as antidiabetic and neuroprotective targets: assessment through in vitro and in silico studies
BackgroundReports have implicated diabetes mellitus (DM) and Alzheimer’s disease (AD) as some of the global persistent health challenges with no...
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Use of homeopathy in feeding piglets as an alternative to reduce fighting behavior in the nursery phase: effects on production and hematological, metabolic, and oxidative variables
This study aimed to determine whether using a homeopathic agent would improve the behavior, growth performance, redox status, and neuroimmune...
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HPLC fingerprint of flavonoids, enzyme inhibition and antioxidant activity of Newbouldia laevis stem-bark: an in vitro and in silico study
BackgroundMedicinal plant contains multiple bioactive compounds with therapeutic potentials. Due to their availability, affordability, and minimal...
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Bergenia pacumbis from Nepal, an astonishing enzymes inhibitor
BackgroundThe Bergenia species are perennial herbs native to central Asia, and one of the most promising medicinal plants of the family...
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Black and non-black population: investigation of the difference in butyrylcholinesterase activity in a healthy population in Salvador, Bahia
IntroductionButyrylcholinesterase (BChE), an important biomarker of exposure to anticholinesterases, varies its activity according to the intensity...
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Evaluation of neuroprotective and anti-amnesic effects of Elaeagnus umbellata Thunb. On scopolamine-induced memory impairment in mice
BackgroundElaeagnus umbellata is abundantly found in Himalayan regions of Pakistan which is traditionally used to treat various health disorders....
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Comparison of bispectral index and patient state index as measures of sedation depth during surgeries using remimazolam tosilate
BackgroundThe Bispectral Index (BIS) and the Patient State Index (PSI) are commonly used measures to assess intraoperative sedation depth. However,...
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Current and Evolving Management of Chronic Hepatitis Delta Virus (HDV) Infection
Purpose of ReviewThis review aims to examine the current and evolving management of chronic hepatitis delta virus (HDV) infection, a severe form of...
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Donepezil-based combination therapy for Alzheimer’s disease and related neuropathies
Combination therapy has birthed improved treatment possibilities for a number of complex and degenerative diseases in the world, which include...
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Association of cholinesterase activities and POD in older adult abdominal surgical patients
BackgroundPostoperative delirium (POD) is a frequent complication after surgery. Older adult patients undergoing abdominal surgery are at higher risk...
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Piperine abates cognitive dysfunction via modulation of key enzymes relevant to neurodegeneration in scopolamine-induced rats
Piperine is a naturally occurring alkaloid found in many plant species especially pepper. It has been known to exert several beneficial therapeutic...
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The promising guide to LC–MS analysis and cholinesterase activity of Luffa cylindrica (L.) fruit using in vitro and in-silico analyses
BackgroundLuffa cylindrica (L.) is an annual climbing plant that produces fibrous fruit and can also be used as a vegetable in northern parts of...
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The prevalence, mechanism of action, and toxicity of Nigerian psychoactive plants
Cannabis sativa, Datura stramonium, Nicotiana tabacum, and Carica papaya are plants that naturally grow in Nigeria. They are reportedly rich in...
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Global trend of clinical biomarkers of health and disease during the period (1913–2021): systematic review and bibliometric analysis
BackgroundThe literature review provides a concise and detailed description of the available and published data on the investigated research problem....
