Search
Search Results
-
Chinese guideline for the diagnosis and treatment of drug-induced liver injury: an update
Drug-induced liver injury (DILI) is an important adverse drug reaction that can lead to acute liver failure or even death in severe cases. Currently,...
-
Drug-induced liver injury due to tofacitinib: a case report
BackgroundDrug-induced liver injury is an acute or chronic liver damage in response to drugs, herbals, and any chemical compound.
Case presentation ... -
Drug-Induced Liver Injury in the Elderly: Consensus Statements and Recommendations from the IQ-DILI Initiative
The elderly demographic is the fastest-growing segment of the world’s population and is projected to exceed 1.5 billion people by 2050. With...
-
Identification of MRI features associated with injury type, severity, and prognosis in drug-induced liver injury
ObjectivesTo identify magnetic resonance imaging (MRI) features associated with injury type, severity, and liver transplantation (LT)/liver-related...
-
Interpretable machine learning in predicting drug-induced liver injury among tuberculosis patients: model development and validation study
BackgroundThe objective of this research was to create and validate an interpretable prediction model for drug-induced liver injury (DILI) during...
-
A brief overview of drug-induced liver damage
Drug-induced liver injury (DILI) is a prevalent disorder that can be led on by almost all drug types. The majority of benign DILI cases become better...
-
Unraveling the treatment effects of huanglian jiedu decoction on drug-induced liver injury based on network pharmacology, molecular docking and experimental validation
Huanglian Jiedu Decoction (HJD) is a well-known Traditional Chinese Medicine formula that has been used for liver protection in thousands of years....
-
Cholestatic liver injury secondary to over-the-counter cyproheptadine: case report and review of literature
BackgroundCyproheptadine is an easily available over-the-counter first-generation antihistaminic that is often used as an appetite stimulant....
-
Mechanism of drug-induced liver injury and hepatoprotective effects of natural drugs
Drug-induced liver injury (DILI) is a common adverse drug reaction (ADR) and a serious threat to health that affects disease treatments. At present,...
-
Amiodarone and Dronedarone Causes Liver Injury with Distinctly Different Clinical Presentations
ObjectiveTo describe hepatotoxicity due to amiodarone and dronedarone from the DILIN and the US FDA’s surveillance database.
MethodsHepatotoxicity...
-
MicroRNA-29a-3p Prevents Drug-Induced Acute Liver Failure through Inflammation-Related Pyroptosis Inhibition
ObjectiveLittle is known about the role of microRNA-29a-3p (miR-29a-3p) in inflammation-related pyroptosis, especially in drug-induced acute liver...
-
Liver injury in children: signal analysis of suspected drugs based on the food and drug administration adverse event reporting system
BackgroundEvidence of drug-induced liver injury is abundant in adults but is lacking in children. Our aim was to identify suspected drug signals...
-
Drug-induced liver injury: Asia Pacific Association of Study of Liver consensus guidelines
Idiosyncratic drug-induced liver injury mimics acute and chronic liver disease. It is under recognized and underrecognised because of the lack of...
-
Functional Food Chemical Ingredient Strategies for Non-alcoholic Fatty Liver Disease (NAFLD) and Hepatic Fibrosis: Chemical Properties, Health Benefits, Action, and Application
Purpose of ReviewThe liver is an important digestive gland in the body. Lifestyle and dietary habits are increasingly damaging our liver, leading to...
-
Mifepristone induced liver injury in a patient with Cushing syndrome: a case report and review of the literature
BackgroundMifepristone, also known as RU-486, is an anti-progestational steroid with similar chemical structure to anabolic steroids. Given as a...
-
Acute liver injury in a non-alcoholic fatty liver disease patient with chloroform exposure: a case report
We report a rare case of acute liver injury by daily exposure to small amounts of chloroform in non-alcoholic fatty liver disease (NAFLD) patient....
-
Protective role of thymoquinone in hyperlipidemia-induced liver injury in LDL-R−/−mice
BackgroundHyperlipidemia, a heterogeneous group of disorders characterized by elevated plasma lipids in the blood, causes severe health problems,...
-
Gynostemma Pentaphyllum ameliorates CCl4-induced liver injury via PDK1/Bcl-2 pathway with comprehensive analysis of network pharmacology and transcriptomics
BackgroundGynostemma pentaphyllum (Thunb.) Makino, commonly known as “southern ginseng”, contains high amounts of ginsenoside derivatives and...
-
Rifaximin Prevents Intestinal Barrier Dysfunction and Alleviates Liver Injury in MCT-induced HSOS Mice
ObjectiveRifaximin is an effective component of treatment strategies for liver and intestinal diseases. However, the efficacy of rifaximin in hepatic...
-
Determinants, profile and outcomes of hepatitis A virus–associated severe acute liver injury in adults
Background and ObjectivesHepatitis A virus (HAV)-related hepatitis is witnessing an epidemiological transition with increasing trends in adults....
