Search
Search Results
-
Signaling pathways and targeted therapies in lung squamous cell carcinoma: mechanisms and clinical trials
Lung cancer is the leading cause of cancer-related death across the world. Unlike lung adenocarcinoma, patients with lung squamous cell carcinoma...
-
Investigation of cellular communication and signaling pathways in tumor microenvironment for high TP53-expressing osteosarcoma cells through single-cell RNA sequencing
Osteosarcoma (OS) stands as the most prevalent primary bone cancer in children and adolescents, and its limited treatment options often result in...
-
Roles and Mechanisms of miRNAs in Abdominal Aortic Aneurysm: Signaling Pathways and Clinical Insights
Purpose of ReviewAbdominal aortic aneurysm refers to a serious medical condition that can cause the irreversible expansion of the abdominal aorta,...
-
Germline determinants of aberrant signaling pathways in cancer
Cancer is a complex disease influenced by a heterogeneous landscape of both germline genetic variants and somatic aberrations. While there is growing...
-
Activated Leukocyte Cell Adhesion Molecule Regulates the Expression of Interleukin-33 in RSV Induced Airway Inflammation by Regulating MAPK Signaling Pathways
PurposeThe respiratory syncytial virus (RSV) is a common respiratory virus that causes acute lower respiratory tract infectious diseases,...
-
Propofol inhibits colon cancer cell stemness and epithelial-mesenchymal transition by regulating SIRT1, Wnt/β-catenin and PI3K/AKT/mTOR signaling pathways
BackgroundPropofol is a common sedative-hypnotic drug used for general anesthesia. Recent studies have drawn attention to the antitumor effects of...
-
Signaling pathways and therapeutic interventions in gastric cancer
Gastric cancer (GC) ranks fifth in global cancer diagnosis and fourth in cancer-related death. Despite tremendous progress in diagnosis and...
-
Signaling pathways in cancer metabolism: mechanisms and therapeutic targets
A wide spectrum of metabolites (mainly, the three major nutrients and their derivatives) can be sensed by specific sensors, then trigger a series of...
-
Signaling pathways in brain tumors and therapeutic interventions
Brain tumors, although rare, contribute to distinct mortality and morbidity at all ages. Although there are few therapeutic options for brain tumors,...
-
Osteoarthritis: pathogenic signaling pathways and therapeutic targets
Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects more than 500 million population worldwide. OA was...
-
Current state of signaling pathways associated with the pathogenesis of idiopathic pulmonary fibrosis
Idiopathic Pulmonary Fibrosis (IPF) represents a chronic and progressive pulmonary disorder distinguished by a notable mortality rate. Despite the...
-
Combination of monensin and erlotinib synergistically inhibited the growth and cancer stem cell properties of triple-negative breast cancer by simultaneously inhibiting EGFR and PI3K signaling pathways
BackgroundCancer stem cells (CSCs) in triple-negative breast cancer (TNBC) are recognized as a highly challenging subset of cells, renowned for their...
-
Signaling pathways and targeted therapies for psoriasis
Psoriasis is a common, chronic, and inflammatory skin disease with a high burden on individuals, health systems, and society worldwide. With the...
-
Ntrk1 promotes mesangial cell proliferation and inflammation in rat glomerulonephritis model by activating the STAT3 and p38/ERK MAPK signaling pathways
BackgroundMesangial proliferative glomerulonephritis (MsPGN) accounts for a main cause of chronic kidney disease (CKD), chronic renal failure and...
-
Signaling pathways in vascular function and hypertension: molecular mechanisms and therapeutic interventions
Hypertension is a global public health issue and the leading cause of premature death in humans. Despite more than a century of research,...
-
Signaling pathways in rheumatoid arthritis: implications for targeted therapy
Rheumatoid arthritis (RA) is an incurable systemic autoimmune disease. Disease progression leads to joint deformity and associated loss of function,...
-
Signaling pathways and potential therapeutic targets in acute respiratory distress syndrome (ARDS)
Acute respiratory distress syndrome (ARDS) is a common condition associated with critically ill patients, characterized by bilateral chest...
-
Oncogenic metabolic reprogramming in breast cancer: focus on signaling pathways and mitochondrial genes
Oncogenic metabolic reprogramming impacts the abundance of key metabolites that regulate signaling and epigenetics. Metabolic vulnerability in the...
-
lncRNA-microRNA axis in cancer drug resistance: particular focus on signaling pathways
Cancer drug resistance remains a formidable challenge in modern oncology, necessitating innovative therapeutic strategies. The convergence of...
-
Dynamics and Sensitivity of Signaling Pathways
Purpose of ReviewSignaling pathways serve to communicate information about extracellular conditions into the cell, to both the nucleus and...
