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Identification and validation of tumor-specific T cell receptors from tumor infiltrating lymphocytes using tumor organoid co-cultures
T cell receptor-engineered T cells (TCR-Ts) therapy is promising for cancer immunotherapy. Most studies have focused on identifying tumor-specific T...
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Tumor heterogeneity and immune-evasive T follicular cell lymphoma phenotypes at single-cell resolution
T follicular helper (T FH ) cell lymphomas (TFHLs) are characterized by T FH -like properties and accompanied by substantial immune-cell infiltration...
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Global research trends in tumor stem cell-derived exosomes and tumor microenvironment: visualization biology analysis
BankgroundThe tumor microenvironment (TME) is an internal environment composed of various cells and an extracellular matrix. Cancer stem cell-derived...
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Tumor heterogeneity in VHL drives metastasis in clear cell renal cell carcinoma
Loss of function of the von Hippel-Lindau (VHL) tumor suppressor gene is a hallmark of clear cell renal cell carcinoma (ccRCC). The importance of...
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Estrogen-related receptor alpha promotes thyroid tumor cell survival via a tumor subtype-specific regulation of target gene networks
Mortalin (encoded by HSPA9 ) is a mitochondrial chaperone often overexpressed in cancer through as-yet-unknown mechanisms. By searching different...
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Predictive value of cyst/tumor volume ratio of pituitary adenoma for tumor cell proliferation
BackgroundMRI has been widely used to predict the preoperative proliferative potential of pituitary adenoma (PA). However, the relationship between...
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Immunomodulatory Function of Pien Tze Huang in T Cell-Mediated Anti-tumor Activity against B16–F10, MC38 and Hep1-6 Tumor Models
ObjectiveTo investigate the anti-tumor effects of Pien Tze Huang (PZH) in mouse models of B16–F10 melanoma, MC38 colorectal cancer, Hep1-6...
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Tenosynovial giant cell tumor: a case report
BackgroundThis case reports the synchronous diagnosis of two rare unrelated diseases; leiomyosarcoma and tenosynovial giant cell tumor of the knee....
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Tumor cell integrin β4 and tumor stroma E-/P-selectin cooperatively regulate tumor growth in vivo
BackgroundThe immunological composition of the tumor microenvironment has a decisive influence on the biological course of cancer and is therefore of...
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Intravenous injection of tumor extracellular vesicles suppresses tumor growth by reducing the regulatory T cell phenotype
BackgroundColorectal cancer is a disease of unmet medical need. Although extracellular vesicles (EVs) have been implicated in anti-tumor responses,...
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Definitive chemoradiotherapy induces T-cell-inflamed tumor microenvironment in unresectable locally advanced esophageal squamous cell carcinoma
BackgroundChemoradiotherapy (CRT) modulates the tumor immune microenvironment of multiple cancer types, including esophageal cancer, which...
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Giant Cell Tumor of Mandible : A Case Report
Giant cell tumor is locally aggressive primary benign neoplasm of bone with tendency of frequent recurrence, metastasis and malignant transformation....
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Tumor-to-tumor spread: a case report and literature review of renal cell carcinoma metastasis into thyroid cancer
Tumor-to-tumor metastasis is a rare, yet important entity. Patients with a history of renal cell carcinoma (RCC) may have tumor deposits to the...
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Contrast-enhanced CT radiomics features to preoperatively identify differences between tumor and proximal tumor-adjacent and tumor-distant tissues of resectable esophageal squamous cell carcinoma
BackgroundEsophagectomy is the main treatment for esophageal squamous cell carcinoma (ESCC), and patients with histopathologically negative margins...
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Tumor-derived cell-free DNA and circulating tumor cells: partners or rivals in metastasis formation?
The origin of metastases is a topic that has sparked controversy. Despite recent advancements, metastatic disease continues to pose challenges. The...
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Extra Ovarian Adult Granulosa Cell Tumor: A Rare Clinical Case Report
Adult ovarian granulosa cell tumor is one of the rare types of malignant tumor, which arises from the sex cord granulosa cell of the ovary. The tumor...
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The tumor immune microenvironment and T-cell-related immunotherapies in colorectal cancer
The tumor microenvironment includes a complex network of immune T-cell subsets that play important roles in colorectal cancer (CRC) progression and...
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Tumor Area Positivity (TAP) score of programmed death-ligand 1 (PD-L1): a novel visual estimation method for combined tumor cell and immune cell scoring
BackgroundDetermination of programmed death-ligand 1 (PD-L1) protein expression level in tumor cells and tumor-associated immune cells is critical...
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Immunosuppressive tumor microenvironment contributes to tumor progression in diffuse large B-cell lymphoma upon anti-CD19 chimeric antigen receptor T therapy
Anti-CD19 chimeric antigen receptor (CAR)-T cell therapy has achieved 40%–50% long-term complete response in relapsed or refractory diffuse large...
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Near-infrared photoimmunotherapy induced tumor cell death enhances tumor dendritic cell migration
Near-infrared photoimmunotherapy (NIR-PIT) selectively kills tumor cells to which the photo-absorber dye IR700DX-conjugated antibodies are bound and...
