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Muscarinic receptor activation overrides boundary conditions on memory updating in a calcium/calmodulin-dependent manner
Long-term memory storage is a dynamic process requiring flexibility to ensure adaptive behavioural responding in changing environments. Indeed, it is...
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Calcium/calmodulin-dependent kinases can regulate the TSH expression in the rat pituitary
PurposeThe endocrine secretion of TSH is a finely orchestrated process controlled by the thyrotropin-releasing hormone (TRH). Its homeostasis and...
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Interactions of calmodulin kinase II with the dopamine transporter facilitate cocaine-induced enhancement of evoked dopamine release
Typical and atypical dopamine uptake inhibitors (DUIs) prefer distinct conformations of the dopamine transporter (DAT) to form ligand-transporter...
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Recessive variants in MYO1C as a potential novel cause of proteinuric kidney disease
BackgroundSteroid-resistant nephrotic syndrome is the second leading cause of chronic kidney disease among patients < 25 years of age. Through exome...
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A Mitochondrial Basis for Heart Failure Progression
In health, the human heart is able to match ATP supply and demand perfectly. It requires 6 kg of ATP per day to satisfy demands of external work...
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Correction to: Myoclonic dystonia phenotype related to a novel calmodulin-binding transcription activator 1 sequence variant
The affiliation of author Robert Jech was incorrectly indicated in the originally published version of this paper.
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Expression, Regulation, and Function of the Calmodulin Accessory Protein PCP4/PEP-19 in Myometrium
Objective: Calmodulin (CaM) plays a key role in the orchestration of Ca 2+ signaling events, and its regulation is considered an important component...
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CaMKK2 as an emerging treatment target for bipolar disorder
Current pharmacological treatments for bipolar disorder are inadequate and based on serendipitously discovered drugs often with limited efficacy,...
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Calcium/calmodulin-dependent protein kinase IV signaling pathway is upregulated in experimental necrotizing enterocolitis
PurposeActivation of calcium/calmodulin-dependent protein kinase IV (CaMKIV) has been shown to increase intestinal injury and inhibit epithelial cell...
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Erianin, a novel dibenzyl compound in Dendrobium extract, inhibits lung cancer cell growth and migration via calcium/calmodulin-dependent ferroptosis
Ferroptosis, a novel form of programmed cell death, is characterized by iron-dependent lipid peroxidation and has been shown to be involved in...
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The role of protein kinases in diabetic neuropathic pain: an update review
ObjectivesDiabetic neuropathic pain (DNP) is a debilitating symptom of diabetic neuropathy which seriously impairs patient’s quality of life....
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Metalloproteins as risk factors for osteoarthritis: improving and understanding causal estimates using Mendelian randomization
AbstractOsteoarthritis (OA) is one of the most prevalent musculoskeletal disorders and a primary cause of pain and disability among the elderly...
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Role of CaMKII in diabetes induced vascular injury and its interaction with anti-diabetes therapy
Diabetes mellitus is a metabolic disorder denoted by chronic hyperglycemia that drives maladaptive structural changes and functional damage to the...
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Regulation and role of CAMKK2 in prostate cancer
In 2011, CAMKK2 , the gene encoding calcium/calmodulin-dependent kinase kinase 2 (CAMKK2), was demonstrated to be a direct target of the androgen...
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ROS-regulated phosphorylation of ITPKB by CAMK2G drives cisplatin resistance in ovarian cancer
Platinum resistance accounts for much of the high mortality and morbidity associated with ovarian cancer. Identification of targets with significant...
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Exercise-Regulated Mitochondrial and Nuclear Signalling Networks in Skeletal Muscle
Exercise perturbs energy homeostasis in skeletal muscle and engages integrated cellular signalling networks to help meet the contraction-induced...
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Glucose fluctuations aggravate myocardial fibrosis via activating the CaMKII/Stat3 signaling in type 2 diabtetes
BackgroundGlucose fluctuations (GF) are a risk factor for cardiovascular complications associated with type 2 diabetes. However, there is a lack of...
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Inappropriate treatment of pulmonary aspergillosis caused by Aspergillus flavus in susceptible pediatric patients: a case series
BackgroundPulmonary aspergillosis is a prevalent opportunistic fungal infection that can lead to mortality in pediatric patients with underlying...
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What is circulating factor disease and how is it currently explained?
Nephrotic syndrome (NS) consists of the clinical triad of hypoalbuminaemia, high levels of proteinuria and oedema, and describes a heterogeneous...