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Decreasing incidence of hospital diagnosed CKD/CKDu in North Central Province of Sri Lanka: is it related to provision of drinking water reverse osmosis plants?
BackgroundWe assessed the possible impact of provision of reverse osmosis (RO) water on the incidence of hospital diagnosed CKD/CKDu in North Central...
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Prevalence and predictors of chronic kidney disease of undetermined causes (CKDu) in Western Kenya’s “sugar belt”: a cross-sectional study
BackgroundEpidemics of chronic kidney disease of undetermined causes (CKDu) among young male agricultural workers have been observed in many tropical...
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Urinary cystatin C: pediatric reference intervals and comparative assessment as a biomarker of renal injury among children in the regions with high burden of CKDu in Sri Lanka
BackgroundCystatin C (Cys-C) is an emerging biomarker of renal diseases and its clinical use, particularly for screening the communities affected by...
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Heavy metal association with chronic kidney disease of unknown cause in central India-results from a case-control study
BackgroundChronic Kidney Disease of unknown cause (CKDu) a disease of exclusion, and remains unexplained in various parts of the world, including...
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CKD and CKDu in northern Peru: a cross-sectional analysis under the DEGREE protocol
BackgroundThis study estimated the prevalence and risk factors for decreased estimated glomerular filtration rate (eGFR) in those without known...
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Impact of water quality on Chronic Kidney Disease of unknown etiology (CKDu) in Thunukkai Division in Mullaitivu District, Sri Lanka
BackgroundIncrease in the number of cases in Chronic Kidney Disease of Unknown etiology (CKDu) in Sri Lanka has become a health issue of national...
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Kidney disease characteristics, prevalence, and risk factors in León, Nicaragua: a population-based study
BackgroundCKD of unknown etiology (CKDu) disproportionately affects young people in Central America who lack traditional CKD risk factors (diabetes...
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Environmental fluoride exposure and implications on potential pediatric kidney health risks: an approach with urinary biomarkers
BackgroundEnvironmental fluoride exposure at elevated levels is potentially linked to kidney injury, and may contribute to chronic kidney disease of...
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Evidence of selected nephrotoxic elements in Sri Lankan human autopsy bone samples of patients with CKDu and controls
BackgroundThis article describes the analysis and interpretation of data relating to the presence of cadmium, lead, mercury and fluoride in human...
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The politics of glyphosate regulation: lessons from Sri Lanka’s short-lived ban
BackgroundGlyphosate is the world’s most used herbicide and a central component of modern industrial agriculture. It has also been linked to a...
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Randomized control trial of prednisolone and doxycycline in patients with acute interstitial nephritis of unknown aetiology
BackgroundPatients presenting with acute interstitial nephritis (AIN) of unknown aetiology, probably the earliest presentation of chronic kidney...
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High prevalence of chronic kidney disease of unknown etiology among workers in the Mesoamerican Nephropathy Occupational Study
BackgroundMortality from chronic kidney disease of unknown etiology (CKDu) is extremely high along the Pacific coast of Central America, particularly...
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The role of aetiology in cardiac manifestations of chronic kidney disease: the CPH-CKD ECHO study
PurposeWe investigated the associations between cardiac parameters and aetiologies of CKD in an exploratory study.
MethodsThe study population...
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The incidence, prevalence and trends of Chronic Kidney Disease and Chronic Kidney Disease of uncertain aetiology (CKDu) in the North Central Province of Sri Lanka: an analysis of 30,566 patients
BackgroundChronic Kidney Disease (CKD) of uncertain origin (CKDu) has affected North Central Province (Anuradhapura and Polonnaruwa districts) of Sri...
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A pilot case-control study using a one health approach to evaluate behavioral, environmental, and occupational risk factors for chronic kidney disease of unknown etiology in Sri Lanka
BackgroundChronic kidney disease of unknown etiology (CKDu) was first recognized in Sri Lanka in the early 1990s, and since then it has reached...
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Biochemical and histopathological changes in Wistar rats after consumption of boiled and un-boiled water from high and low disease prevalent areas for chronic kidney disease of unknown etiology (CKDu) in north Central Province (NCP) and its comparison with low disease prevalent Colombo, Sri Lanka
BackgroundChronic Kidney Disease of unknown etiology (CKDu) is prevalent in North Central Province (NCP) of Sri Lanka. Consumption of un-boiled dug...
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Pilot study determining the feasibility of implementing the Disadvantaged Populations eGFR Epidemiology Study (DEGREE) protocol, point-of-care field measurements and a new module on risk factors for chronic kidney disease of unknown origin in Hispanic outdoor workers
BackgroundTo field test the Disadvantaged Populations eGFR Epidemiology (DEGREE) protocol, outdoor point-of-care (POC) testing for serum creatinine,...
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Nanocrystal-induced chronic tubular-nephropathy in tropical countries: diagnosis, mitigation, and eradication
In tropical countries, a mysterious tubulo-interstitial chronic renal disease (CKD), unrelated to diabetes, hypertension, and immunological causes,...
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Environmental metal exposures and kidney function of Guatemalan sugarcane workers
BackgroundExposure to environmental metals can cause nephrotoxicity. There is an international epidemic of chronic kidney disease of unknown cause...
