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Development of primary osteoarthritis during aging in genetically diverse UM-HET3 mice
BackgroundPrimary osteoarthritis (OA) occurs without identifiable underlying causes such as previous injuries or specific medical conditions. Age is...
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gom1 Mutant Mice as a Model of Otitis Media
Otitis media (OM) disease is a common cause of hearing loss that is primarily the result of middle ear infection. At present, our understanding of...
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High salt diet does not impact the development of acute myeloid leukemia in mice
The gut microbiota has not only been implicated in the development of some cancers but has also been shown to modulate the efficacy of cancer...
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The efficacy of LED microneedle patch on hair growth in mice
Light penetration depth in the scalp is a key limitation of low-level light therapy for the treatment of androgenetic alopecia (AGA). A novel light...
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Low dose post-transplant cyclophosphamide and sirolimus induce mixed chimerism with CTLA4-Ig or lymphocyte depletion in an MHC-mismatched murine allotransplantation model
Allogeneic hematopoietic cell transplantation (allo-HCT) offers a curative option for patients with certain non-malignant hematological diseases....
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Activation of TLR4 signaling inhibits progression of osteosarcoma by stimulating CD8-positive cytotoxic lymphocytes
BackgroundOsteosarcoma (OS) is the most common malignant bone tumor and the prognosis of advanced cases is still poor. Recently, there have been...
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Transcriptomics analysis reveals molecular alterations underpinning spaceflight dermatology
BackgroundSpaceflight poses a unique set of challenges to humans and the hostile spaceflight environment can induce a wide range of increased health...
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Mitochondrial Genetics and Function as Determinants of Bone Phenotype and Aging
Purpose of ReviewThe purpose of this review is to summarize the recently published scientific literature regarding the effects of mitochondrial...
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LITAF Promotes Atherosclerotic Plaque Formation by Stimulating the NF-κB Inflammatory Pathway
ObjectiveLipopolysaccharide-induced tumor necrosis factor-α factor (LITAF) protein is a newly discovered inflammatory protein. This study aims to...
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Mechanisms Behind NAFLD: a System Genetics Perspective
Purpose of ReviewTo summarize the key factors contributing to the onset and progress of nonalcoholic fatty liver disease (NAFLD) and put them in a...
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Sulfated Galactofucan from Sargassum Thunbergii Attenuates Atherosclerosis by Suppressing Inflammation Via the TLR4/MyD88/NF-κB Signaling Pathway
PurposeSulfated galactofucan (SWZ-4), which was extracted from Sargassum thunbergii, has recently been reported to show anti-inflammatory and...
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Two polygenic mouse models of major depressive disorders identify TMEM161B as a potential biomarker of disease in humans
Treatments are only partially effective in major depressive disorders (MDD) but no biomarker exists to predict symptom improvement in patients....
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Electrochemical therapy (EChT) of cancer tumor with an external anode, a way to achieve pathological complete response
There is a critical need for re-evaluation of electrochemical therapy (EChT) approaches of solid tumors to address the challenges of the currently...
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Effect of lethal total body irradiation on bone marrow chimerism, acute graft-versus-host disease, and tumor engraftment in mouse models: impact of different radiation techniques using low- and high-energy X-rays
PurposeEffects of X‑ray energy levels used for myeloablative lethal total body irradiation (TBI) delivery prior to bone marrow transplantation (BMT)...
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Leptin production capacity determines food intake and susceptibility to obesity-induced diabetes in Oikawa–Nagao Diabetes-Prone and Diabetes-Resistant mice
Aims/hypothesisObesity caused by overeating plays a pivotal role in the development of type 2 diabetes. However, it remains poorly understood how...
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Interorgan communication networks in the kidney–lung axis
The homeostasis and health of an organism depend on the coordinated interaction of specialized organs, which is regulated by interorgan communication...
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Alpinetin promotes hair regeneration via activating hair follicle stem cells
BackgroundAlopecia affects millions of individuals globally, with hair loss becoming more common among young people. Various traditional Chinese...
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How does Hashimoto’s thyroiditis affect bone metabolism?
Bone marrow contains resident cellular components that are not only involved in bone maintenance but also regulate hematopoiesis and immune...
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Tuberculous Meningitis: an Update on the Pathogenesis and Neuroimmunology
Purpose of ReviewTuberculosis meningitis (TBM) carries the highest morbidity and mortality of any type of tuberculosis infection, yet the definitive...
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Selective depletion of tumor-infiltrating regulatory T cells with BAY 3375968, a novel Fc-optimized anti-CCR8 antibody
Regulatory T cells (Tregs) are known to facilitate tumor progression by suppressing CD8+ T cells within the tumor microenvironment (TME), thereby...
