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Brain-lung crosstalk: how should we manage the breathing brain?
Recent studies have drawn increasing attention to brain-lung crosstalk in critically ill patients. However, further research is needed to investigate...
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Brain-Lung Crosstalk: Management of Concomitant Severe Acute Brain Injury and Acute Respiratory Distress Syndrome
Purpose of ReviewTo summarize pathophysiology, key conflicts, and therapeutic approaches in managing concomitant severe acute brain injury (SABI) and...
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ARDS associated acute brain injury: from the lung to the brain
A complex interrelation between lung and brain in patients with acute lung injury (ALI) has been established by experimental and clinical studies...
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Organ Crosstalk in Acute Kidney Injury Basic Concepts and Clinical Practices
This is an original work dedicated to an important and current topic in nephrology: organ crosstalk in acute renal injury.
Acute kidney injury is a...
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Bone-organ axes: bidirectional crosstalk
In addition to its recognized role in providing structural support, bone plays a crucial role in maintaining the functionality and balance of various...
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Mitochondria-Associated Organelle Crosstalk in Myocardial Ischemia/Reperfusion Injury
Organelle damage is a significant contributor to myocardial ischemia/reperfusion (I/R) injury. This damage often leads to disruption of endoplasmic...
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Crosstalk Between the Nervous System and Systemic Organs in Acute Brain Injury
Organ crosstalk is a complex biological communication between distal organs mediated via cellular, soluble, and neurohormonal actions, based on a...
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Pressure-support compared with pressure-controlled ventilation mitigates lung and brain injury in experimental acute ischemic stroke in rats
BackgroundWe aimed to evaluate the pulmonary and cerebral effects of low-tidal volume ventilation in pressure-support (PSV) and pressure-controlled...
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The Role of Tumor Epithelial-Mesenchymal Transition and Macrophage Crosstalk in Cancer Progression
Purpose of ReviewThe purpose of this review is to summarize the recently published findings regarding the role of epithelial to mesenchymal...
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Neuroimmune crosstalk and its impact on cancer therapy and research
Cancer is a major health problem as it is the first or second leading cause of death worldwide. The global cancer burden is expected to rise 47%...
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The SUMOylation and ubiquitination crosstalk in cancer
BackgroundThe cancer occurrence and progression are largely affected by the post-translational modifications (PTMs) of proteins. Currently, it has...
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Targeting crosstalk of signaling pathways in cancer stem cells: a promising approach for development of novel anti-cancer therapeutics
Wnt, Hedgehog (Hh), and Notch signaling pathways are the evolutionarily conserved signaling pathways that regulate the embryonic development and also...
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Exosome-mediated crosstalk between tumor cells and innate immune cells: implications for cancer progression and therapeutic strategies
The increasing number of cancer-associated deaths despite the substantial improvement in diagnosis and treatment has sparked discussions on the need...
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Crosstalk of human coronary perivascular adipose-derived stem cells with vascular cells: role of tissue factor
The coronary perivascular adipose tissue (cPVAT) has been associated to the burden of cardiovascular risk factors and to the underlying vessel...
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Neuroimmune crosstalk
Cardiovascular diseases are the leading cause of death worldwide. Pathophysiologically, metabolic and inflammatory processes contribute substantially...
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Insights into Nimbolide molecular crosstalk and its anticancer properties
Nimbolide, one of the main ingredients constituent of Azadirachta indica (neem) leaf extract, has garnered attention for its potential as an...
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Exosomal mediators in sepsis and inflammatory organ injury: unraveling the role of exosomes in intercellular crosstalk and organ dysfunction
Sepsis, a severe systemic inflammatory response to infection, remains a leading cause of morbidity and mortality worldwide. Exosomes, as mediators of...
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Cardiovascular complications of diabetes: role of non-coding RNAs in the crosstalk between immune and cardiovascular systems
Diabetes mellitus, a group of metabolic disorders characterized by high levels of blood glucose caused by insulin defect or impairment, is a major...
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An overview of the crosstalk between YAP and cGAS-STING signaling in non-small cell lung cancer: it takes two to tango
The cyclic GMP-AMP synthase (cGAS)—stimulator of interferon genes (STING) pathway is recognized as a main mediator bridging innate and adaptive...
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Crosstalk among Oxidative Stress, Autophagy, and Apoptosis in the Protective Effects of Ginsenoside Rb1 on Brain Microvascular Endothelial Cells: A Mixed Computational and Experimental Study
ObjectiveBrain microvascular endothelial cells (BMECs) were found to shift from their usually inactive state to an active state in ischemic stroke...