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Informing the development of an outcome set and banks of items to measure mobility among individuals with acquired brain injury using natural language processing
BackgroundThe sheer number of measures evaluating mobility and inconsistencies in terminology make it challenging to extract potential core domains...
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Fertility preservation in males with cancer of trends, region development, and efficacy in mainland China from 16 regions Chinese sperm banks
PurposeMale cancer survivors experience confusion about fertility following cancer treatment. The aims of this study were to evaluate survivors’...
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Brain morphometry and estimation of aging brain in subjects with congenital untreated isolated GH deficiency
PurposeIndividuals with isolated GH deficiency (IGHD) due to a mutation in the GHRH receptor gene have a normal life expectancy and above 50 years of...
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It’s the Biology Orthopods! Heralding a Reconstructive Revolution Through Musculoskeletal Tissue Banks (MSTB) in India
BackgroundA tissue bank is an establishment that aids in retrieval, processing, storage, and distribution of human tissue for transplantation. For...
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Facial emotion recognition deficits are associated with hypomimia and related brain correlates in Parkinson’s disease
Hypomimia is a frequent manifestation in Parkinson's disease (PD) that can affect interpersonal relationships and quality of life. Recent studies...
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The brain-first vs. body-first model of Parkinson’s disease with comparison to alternative models
The ultimate origin of Lewy body disorders, including Parkinson’s disease (PD) and Dementia with Lewy bodies (DLB), is still incompletely understood....
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Novel effects of Ras-MAPK pathogenic variants on the develo** human brain and their link to gene expression and inhibition abilities
The RASopathies are genetic syndromes associated with pathogenic variants causing dysregulation of the Ras/mitogen-activated protein kinase...
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Healthy blood, healthy brain: a window into understanding and treating neurodegenerative diseases
Our limited understanding of complex neurodegenerative disorders has held us back on the development of efficient therapies. While several approaches...
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Obesity and brain structure in schizophrenia – ENIGMA study in 3021 individuals
Schizophrenia is frequently associated with obesity, which is linked with neurostructural alterations. Yet, we do not understand how the brain...
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The Relationship between History of Traumatic Brain Injury and Longitudinal Changes in Cortical Thickness among Patients with Alzheimer’s Disease
BackgroundThere has been little direct examination of how traumatic brain injury (TBI) affects the rate of neurodegeneration for individuals with...
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Cost-effectiveness and threshold analysis of deep brain stimulation vs. treatment-as-usual for treatment-resistant depression
Treatment-resistant depression (TRD) affects approximately 2.8 million people in the U.S. with estimated annual healthcare costs of $43.8 billion....
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End-to-End Multi-task Learning Architecture for Brain Tumor Analysis with Uncertainty Estimation in MRI Images
Brain tumors are a threat to life for every other human being, be it adults or children. Gliomas are one of the deadliest brain tumors with an...
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Single-cell and spatial transcriptomics: deciphering brain complexity in health and disease
In the past decade, single-cell technologies have proliferated and improved from their technically challenging beginnings to become common laboratory...
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Population-based body–brain map** links brain morphology with anthropometrics and body composition
Understanding complex body–brain processes and the interplay between adipose tissue and brain health is important for understanding comorbidity...
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Altered gene expression in human brain microvascular endothelial cells in response to the infection of influenza H1N1 virus
Influenza viruses not only cause respiratory illness, but also have been reported to elicit neurological manifestations following acute viral...
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Widespread choroid plexus contamination in sampling and profiling of brain tissue
The choroid plexus, a tissue responsible for producing cerebrospinal fluid, is found predominantly in the lateral and fourth ventricles of the brain....
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Macrostructural brain alterations at midlife are connected to cardiovascular and not inherited risk of future dementia: the PREVENT-Dementia study
BackgroundMacrostructural brain alterations in the form of brain atrophy or cortical thinning typically occur during the prodromal Alzheimer’s...
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Epigenome-wide association study of alcohol use disorder in five brain regions
Alcohol use disorder (AUD) is closely linked to the brain regions forming the neurocircuitry of addiction. Postmortem human brain tissue enables the...
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Structural brain changes in patients with persistent headache after COVID-19 resolution
Headache is among the most frequently reported symptoms after resolution of COVID-19. We assessed structural brain changes using T1- and...
