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Box–Behnken design-assisted optimization of RP-HPLC method for the estimation of evogliptin tartrate by analytical quality by design
BackgroundA quality by design approach can potentially lead to a more robust/rugged method development due to emphasis on the risk assessment and...
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Optimization of the extraction process for Shenshou Taiyi powder based on Box-Behnken experimental design, standard relation, and FAHP-CRITIC methods
BackgroundAncient classic prescription play a crucial role in the preservation and advancement of traditional Chinese medicine (TCM) theories. They...
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Design expert as a statistical tool for optimization of 5-ASA-loaded biopolymer-based nanoparticles using Box Behnken factorial design
BackgroundThe overall objective was to prepare a highly accurate nanocarrier system of mesalamine for the treatment of ulcerative colitis with...
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Development, optimization and characterization of flurbiprofen matrix transdermal drug delivery system using Box–Behnken statistical design
BackgroundPresent investigation for research was to develop matrix-type transdermal drug delivery system of flurbiprofen (FBP) with the various ratio...
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Application of Box–Behnken design and desirability function in the development and optimization of self-nanoemulsifying drug delivery system for enhanced dissolution of ezetimibe
BackgroundThis study is focused on develo** and optimizing a self-nanoemulsifying drug delivery system (SNEDDS) of BCS class II drug (ezetimibe)...
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A DoE-based development and characterization of Nadifloxacin-loaded transethosomal gel for the treatment of Acne vulgaris
BackgroundThe objective of this current research was to enhance the topical delivery of Nadifloxacin (NDFX) by incorporating it into a transethosomal...
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Development and optimization of Ropinirole loaded self-nanoemulsifying tablets
BackgroundThe present research work aims to develop a Ropinirole-loaded self-Nanoemulsifying Drug Delivery system. Ropinirole has limited oral...
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In vitro characterization of self-emulsifying drug delivery system-based lipsticks loaded with ketoconazole
BackgroundSelf-emulsifying system-based lipstick may prove to have the potential of enhancing moisturizing characteristics and delivering hydrophobic...
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Formulation development, optimization and characterization of mucoadhesive minitablets of cefuroxime axetil: in vitro, ex vivo and in vivo pharmacokinetic evaluation
BackgroundThe current study expands on the use of design of experiment in develo** cefuroxime axetil mucoadhesive minitablets for treating...
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Development and validation of RP-HPLC method for estimation of brexpiprazole in its bulk and tablet dosage form using Quality by Design approach
BackgroundA new, sensitive, suitable, clear, accurate, and robust reversed-phase high-performance liquid chromatography (RP-HPLC) method for the...
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Optimization of simvastatin transdermal patch for hyperlipidemia treatment in rat model
ObjectiveBiopharmaceutics Classification System says that simvastatin (SMV) is a Class II drug with low bioavailability (5%). This is because it...
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DoE approach for development of localized controlled release microspheres of Vancomycin for treatment of septic arthritis
BackgroundSeptic arthritis is a worse condition of RA that is associated with significant morbidity and mortality. Septic arthritis develops due to...
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Concurrent chromatographic determination of pseudoephedrine and loratadine from combination syrups and tablets
BackgroundChromatographic separation of polar and nonpolar compounds when presented in combined dosage forms has always been considered as great...
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QbD-driven RP-HPLC method for novel chemo-herbal combination, in-silico, force degradation studies, and characterization of dual drug-loaded polymeric and lipidic nanocarriers
BackgroundIn cancer therapies, chemo-herbal combinations are receiving increased attention. A multiple tyrosine kinase inhibitor, lenvatinib (LTB) is...
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Design and optimization of nano invasomal gel of Glibenclamide and Atenolol combination: in vitro and in vivo evaluation
BackgroundThere are many circumstances where chronic disease is associated with other disorders, especially in diseases such as diabetes with...
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Optimization of inulin production process parameters using response surface methodology
BackgroundChicory is one of the major source of inulin. In our study, Box–Behnken model/response surface analysis (RSM) was used for the optimization...
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New lipase-producing Streptomyces isolated from halo-alkaline habitat in Wadi El Natrun: polyphasic identification and statistical optimization of enzyme production
BackgroundBioprospecting lipase producers in non-conventional habitats are the way to find special enzymes of diverse applications. Halo-alkaline...
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Optimized chronomodulated dual release bilayer tablets of fexofenadine and montelukast: quality by design, development, and in vitro evaluation
BackgroundThe conventional oral dosage forms are not effective in dealing with chronopathological conditions, such as nocturnal asthma. Therefore,...
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Niosomal formulation of mefenamic acid for enhanced cancer targeting; preparation, characterization and biodistribution study using radiolabeling technique
BackgroundThis work aimed to prepare niosomal formulations of an anticancer agent [mefenamic acid (MEF)] to enhance its cancer targeting. 131 I was...
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Nano-Stevia reduces the liver injury caused by streptozotocin (STZ)-induced diabetes in rats by targeting PEPCK/GCK genes, INSR pathway and apoptosis
ObjectivesExtensive application of stevia in the treatment of type 2 diabetes mellitus (DM) has been proven by a large number of previous studies. We...
