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Estradiol increases cortical and trabecular bone accrual and bone strength in an adolescent male-to-female mouse model of gender-affirming hormone therapy
The effects of gender-affirming hormone therapy on the skeletal integrity and fracture risk in transitioning adolescent trans girls are unknown. To...
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Inflammation induces stunting by lowering bone mass via GH/IGF-1 inhibition in very preterm infants
BackgroundSustained systemic inflammatory response (SIR) was associated with poor postnatal growth in very preterm infants (VPI). We hypothesize that...
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Genetic Evaluation for Monogenic Disorders of Low Bone Mass and Increased Bone Fragility: What Clinicians Need to Know
Purpose of ReviewThe purpose of this review is to outline the principles of clinical genetic testing and to provide practical guidance to clinicians...
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Puberty and Bone Health in Chronic Disease
Linear growth, onset of and progress through puberty are all adversely affected by chronic diseases during childhood and adolescence. Peak bone mass...
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Cross-sectional and longitudinal associations between the 24-hour movement behaviours, including muscle and bone strengthening activity, with bone and lean mass from childhood to adolescence
BackgroundThis study aimed to assess whether moderate-to-vigorous physical activity (MVPA), sport and exercise as a proxy measure of muscle and bone...
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Repeatability of 18F-FDG uptake in metastatic bone lesions of breast cancer patients and implications for accrual to clinical trials
BackgroundStandard measures of response such as Response Evaluation Criteria in Solid Tumors are ineffective for bone lesions, often making breast...
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Does Aging Activate T-cells to Reduce Bone Mass and Quality?
Purpose of ReviewAging leads to decline in bone mass and quality starting at age 30 in humans. All mammals undergo a basal age-dependent decline in...
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Bone mass and biomarkers in young women with anorexia nervosa: a prospective 3-year follow-up study
IntroductionAnorexia nervosa (AN) increases the risk of impaired bone health, low areal bone mineral density (aBMD), and subsequent fractures. This...
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Bone Material Properties in Bone Diseases Affecting Children
Purpose of ReviewMetabolic and genetic bone disorders affect not only bone mass but often also the bone material, including degree of mineralization,...
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Resistance training presents beneficial effects on bone development of adolescents engaged in swimming but not in impact sports: ABCD Growth Study
BackgroundSports practice during adolescence is important to enhance bone development, although it may provide different effects depending on the...
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Pubertal increment in insulin resistance is negatively related to lumbar bone mineral density in 18-year-old males
SummaryTransient insulin resistance seen during puberty is expected to favour body growth, but our results show that increment in insulin resistance...
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Bone mass in Saudi women aged 20–40 years: the association with obesity and vitamin D deficiency
SummaryThis study describes that low bone density is prevalent in premenopausal Saudi women, especially women of normal weight and vitamin D...
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Bone health and physical activity in adolescents with juvenile idiopathic arthritis: a cross-sectional case-control study
BackgroundAdolescents with juvenile idiopathic arthritis (JIA) tend to engage in less physical activity than their typically develo** peers....
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Bone Tissue Responsiveness To Mechanical Loading—Possible Long-Term Implications of Swimming on Bone Health and Bone Development
Purpose of ReviewTo revisit the bone tissue mechanotransduction mechanisms behind the bone tissue response to mechanical loading and, within this...
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Impact of changes in fat mass and lean soft tissue on bone mineral density accrual in adolescents engaged in different sports: ABCD Growth Study
SummaryBody composition can have a significant impact on bone mineral density (BMD) in pediatric patients and may cause bone disease. This study...
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Muscle strength of the upper limbs & biological maturation: associations with bone mass in adolescent athletes of both sexes
The present study aimed to analyze the association between upper and lower limb muscle strength and biological maturation on bone mass in adolescent...
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Bone metabolism in diabetes: a clinician’s guide to understanding the bone–glucose interplay
Skeletal fragility is an increasingly recognised, but poorly understood, complication of both type 1 and type 2 diabetes. Fracture risk varies...
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Dairy products and bone health
Bone mineral mass, geometry and microstructure, hence determinants of fracture risk, result bone accrual during growth and bone loss later in life....
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Association between body mass index, bone bending strength, and BMD in young sedentary women
SummaryThe rationale was to determine whether body mass index (BMI) is a predictor of bone bending strength and bone mineral density (BMD) in young...
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Bone accrual over 18 months of participation in different loading sports during adolescence
SummaryThis study investigated the impact and non-impact sports on bone mineral density accrual in adolescents over 18 months. The impact sports were...