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Identification of significant alteration genes, pathways and TFs induced by LPS in ARDS via bioinformatical analysis
Background and aimsAcute respiratory distress syndrome (ARDS) or acute lung injury (ALI) is one of the most common acute thoracopathy with...
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Identifying the hub gene and immune infiltration of osteoarthritis by bioinformatical methods
BackgroundNowadays, there are more and more people who have been diagnosed osteoarthritis (OA). However, due to the complex changes of OA, the...
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Identification of Significant Genes and Pathways in Acute Pancreatitis via Bioinformatical Analysis
Background and AimsAcute pancreatitis (AP) is one of the common acute abdominal diseases with complicated pathogenesis. The purpose of this study is...
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High EVI1 and PARP1 expression as favourable prognostic markers in high-grade serous ovarian carcinoma
BackgroundMechanisms of development and progression of high-grade serous ovarian cancer (HGSOC) are poorly understood. EVI1 and PARP1, part of TGF-ß...
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Effects of febrile seizures in mesial temporal lobe epilepsy with hippocampal sclerosis on gene expression using bioinformatical analysis
BackgroundTo investigate the effect of long-term febrile convulsions on gene expression in mesial temporal lobe epilepsy with hippocampal sclerosis...
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Identification of significant genes with poor prognosis in ovarian cancer via bioinformatical analysis
Ovarian cancer (OC) is the highest frequent malignant gynecologic tumor with very complicated pathogenesis. The purpose of the present academic work...
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Forensically relevant anatomical brain regions cannot be sub-differentiated by RNA expression analysis
The contextualization of biological traces generated by severe head injuries can be beneficial for criminal investigations. Here we aimed to identify...
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Comparative bioinformatical analysis of pancreatic head cancer and pancreatic body/tail cancer
This study is to analyze differentially expressed genes (DEGs) and mutation signatures of pancreatic head cancer and pancreatic body/tail cancer....
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Copy number variation analysis identifies MIR9-3 and MIR1299 as novel miRNA candidate genes for CAKUT
BackgroundCongenital anomalies of the kidney and urinary tract (CAKUT) represent a frequent cause of pediatric kidney failure. CNVs, as a major class...
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Demethylase FTO enhances the PI3K/Akt signaling to promote gastric cancer malignancy
Enhanced expression of fat mass and obesity-associated protein (FTO) has been reported in gastric cancer (GC). Bioinformatical studies indicate that...
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The potential drug for treatment in pancreatic adenocarcinoma: a bioinformatical study based on distinct drug databases
BackgroundThe prediction of drug-target interaction from chemical and biological data can advance our search for potential drug, contributing to a...
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Mendelian Randomization Analysis Identified Potential Genes Pleiotropically Associated with Polycystic Ovary Syndrome
Polycystic ovary syndrome (PCOS) is a common endocrine disorder with unclear etiology. Some genes may be pleiotropically or potentially causally...
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Icb-1 expression inhibits growth and fulvestrant response of breast cancer cells and affects survival of breast cancer patients
PurposeHuman gene icb-1 recently has been reported to be part of a gene expression score predicting response to antiestrogen fulvestrant in breast...
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DAZAP1 overexpression promotes growth of HCC cell lines: a primary study using CEUS
PurposeHepatocellular carcinoma (HCC) is one of the most common types of hepatic carcinoma. The overall prognosis is poor. DAZAP1, a regulator of...
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Identifying hub genes and immune infiltration of osteoarthritis using comprehensive bioinformatics analysis
BackgroundOsteoarthritis (OA) is the most common chronic degenerative joint disorder globally that is characterized by synovitis, cartilage...
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Identification of potential markers for differentiating epithelial ovarian cancer from ovarian low malignant potential tumors through integrated bioinformatics analysis
BackgroundEpithelial ovarian cancer (EOC), as a lethal malignancy in women, is often diagnosed as advanced stages. In contrast, intermediating...
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Gene correlation network analysis to identify regulatory factors in sciatic nerve injury
BackgroundSciatic nerve injury (SNI), which frequently occurs under the traumatic hip and hip fracture dislocation, induces serious complications...
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Molecular genetic testing strategies used in diagnostic flow for hereditary endocrine tumour syndromes
IntroductionAlthough current guidelines prefer the use of targeted testing or small-scale gene panels for identification of genetic susceptibility of...
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Rad54L promotes bladder cancer progression by regulating cell cycle and cell senescence
Bladder cancer (BCa) is the most prevalent cancer of the urinary system, but its pathogenesis is still poorly understood. Several reports have...
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Overexpression of CCNE1 confers a poorer prognosis in triple-negative breast cancer identified by bioinformatic analysis
BackgroundTriple-negative breast cancer (TNBC) is a major subtype of breast cancer. Due to the lack of effective therapeutic targets, the prognosis...
