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The temporal dynamics of transition to psychosis in individuals at clinical high-risk (CHR-P) shows negative prognostic effects of baseline antipsychotic exposure: a meta-analysis
Meta-analytic evidence indicates that baseline exposure to antipsychotics (AP) in individuals at clinical high-risk for psychosis (CHR-P) is...
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Baseline and recurrent exposure to the standard dose of artemisinin-based combination therapies (ACTs) induces oxidative stress and liver damage in mice (BALB/c)
BackgroundIn malaria-endemic countries, repeated intake of artemisinin-based combination therapies (ACTs) is rampant and driven by drug resistance,...
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Interaction between baseline BMI and baseline disease severity predicts greater improvement in negative symptoms in first-episode schizophrenia
Several studies have reported that baseline symptom severity in patients with schizophrenia (SCZ) is associated with the efficacy of antipsychotic...
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A Review of Causal Inference Methods for Estimating the Effects of Exposure Change when Incident Exposure Is Unobservable
Purpose of ReviewResearch questions on exposure change and health outcomes are both relevant to clinical and policy decision making for public...
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Effect of Filgotinib on Body Mass Index (BMI) and Effect of Baseline BMI on the Efficacy and Safety of Filgotinib in Rheumatoid Arthritis
IntroductionThis post hoc analysis of the phase 3 rheumatoid arthritis (RA) filgotinib clinical trial program assessed the effect of filgotinib on...
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The Minhang Pediatric Biobank cohort study: protocol overview and baseline characteristics
BackgroundLittle has been done to establish biobanks for studying the environment and lifestyle risk factors for diseases among the school-age...
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Effects of changes in residential fast-food outlet exposure on Body Mass Index change: longitudinal evidence from 92,211 Lifelines participants
BackgroundEvidence on the association between fast-food outlet exposure and Body Mass Index (BMI) remains inconsistent and is primarily based on...
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Personalized exposure and experience sampling method feedback versus exposure as usual for obsessive–compulsive disorder: a study protocol for a randomized controlled trial
BackgroundPatients with obsessive–compulsive disorder (OCD) suffer from repetitive fearful intrusions which they try to neutralize by performing...
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Baseline azithromycin resistance in the gut microbiota of preterm born infants
BackgroundMacrolides, including azithromycin, are increasingly used in preterm-born infants to treat Ureaplasma infections. The baseline carriage of...
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Assessing exposure to outdoor advertisement for products high in fat, salt and sugar (HFSS); is self-reported exposure a useful exposure metric?
BackgroundExposure to advertising of unhealthy commodities such as fast-food and gambling is recognised as a risk factor for develo**...
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Association of Baseline Frailty with Patient-Reported Outcomes in Systemic Lupus Erythematosus at 1 Year
The relationship of baseline frailty with subsequent patient-reported outcomes in systemic lupus erythematosus (SLE) remains unclear. We assessed...
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Tobacco exposure in adults and children with proteinuric glomerulopathies: a NEPTUNE cohort study
BackgroundTobacco exposure has been recognized as a risk factor for cardiovascular disease (CVD) and progression of kidney disease. Patients with...
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The beneficial effect of prophylactic hydrocortisone treatment in extremely preterm infants improves upon adjustment of the baseline characteristics
BackgroundProphylactic low-dose hydrocortisone (HC) was found to improve survival without bronchopulmonary dysplasia (BPD) in extremely preterm...
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Piloting co-developed behaviour change interventions to reduce exposure to air pollution and improve self-reported asthma-related health
BackgroundExposure to air pollution can exacerbate asthma with immediate and long-term health consequences. Behaviour changes can reduce exposure to...
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Exposure to Endocrine-Disrupting Chemicals and Congenital Heart Diseases: The Pooled Results Based on the Current Evidence
The relationships between maternal exposure to endocrine-disrupting chemicals (EDCs) and congenital heart diseases (CHD) are not elucidated yet. The...
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Childhood PFAS exposure and immunotoxicity: a systematic review and meta-analysis of human studies
BackgroundExposure to poly- and perfluoroalkyl substances (PFAS) may affect infant and childhood health through immunosuppression. However, the...
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Baseline health-related quality of life predicts falls: a secondary analysis of a randomized controlled trial
PurposeAmong older adults, health-related quality of life (HRQoL) and falls are associated. Generic patient-reported outcomes measures (PROMs) assess...
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Inflammatory burden of adolescents with childhood maltreatment: results from baseline data of a school cohort
Increasing studies have investigated inflammatory burden of adults with childhood adversity, but less is known about how childhood maltreatment...
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How to diagnose GERC more effectively: reflections on post-reflux swallow-induced peristaltic wave index and mean nocturnal baseline impedance
IntroductionPost-reflux swallow-induced peristaltic wave index ( PSPWI) and mean nocturnal baseline impedance (MNBI) are novel parameters reflect...
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Association between baseline office blood pressure level and the incidence and development of long-term frailty in the community-dwelling very elderly with hypertension
Frailty is the most important risk factor causing disability in the elderly. Hypertension is one of the most common chronic diseases in the elderly...
