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Flanagan’s condensed protocol for neurodegenerative diseases. Implementation in a clinical autopsy setting with partial supervision of a neuropathologist
The Condensed Protocol (CP) was originally developed for the evaluation of Alzheimer’s Disease (AD) and other neurodegenerative diseases as a...
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Mutation ∆K281 in MAPT causes Pick’s disease
Two siblings with deletion mutation ∆K281 in MAPT developed frontotemporal dementia. At autopsy, numerous inclusions of hyperphosphorylated 3R Tau...
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Characteristic asymmetric limbic and anterior temporal atrophy in demented patients with pathologically confirmed argyrophilic grain disease
PurposeThe purpose of this study is to clarify the characteristic structural magnetic resonance imaging (MRI) findings in demented patients with...
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Evolving concepts in progressive supranuclear palsy and other 4-repeat tauopathies
Tauopathies are classified according to whether tau deposits predominantly contain tau isoforms with three or four repeats of the microtubule-binding...
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Patterns of amygdala region pathology in LATE-NC: subtypes that differ with regard to TDP-43 histopathology, genetic risk factors, and comorbid pathologies
Transactive response (TAR) DNA-binding protein 43 kDa (TDP-43) pathology is a hallmark of limbic-predominant age-related TDP-43 encephalopathy...
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Histopathologic brain age estimation via multiple instance learning
Understanding age acceleration, the discordance between biological and chronological age, in the brain can reveal mechanistic insights into normal...
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Frontotemporal lobar degeneration with TAR DNA-binding protein 43 (TDP-43): its journey of more than 100 years
Frontotemporal lobar degeneration (FTLD) with TDP-43-immunoreactive inclusions (FTLD–TDP) is a neurodegenerative disease associated with clinical,...
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Frontotemporal lobar degeneration in the “Annual of the Pathological Autopsy Cases in Japan”
BackgroundGood accuracy for the clinical diagnosis of frontotemporal lobar degeneration (FTLD) by specialists in an early onset dementia clinic has...
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Genetic forms of tauopathies: inherited causes and implications of Alzheimer’s disease-like TAU pathology in primary and secondary tauopathies
Tauopathies are a heterogeneous group of neurologic diseases characterized by pathological axodendritic distribution, ectopic expression, and/or...
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The kidney histopathological spectrum of patients with kidney injury following snakebite envenomation in India: sco** review of five decades
IntroductionSnakebite is a public health problem leading to about 58,000 deaths every year in India. Kidney injury subsequent to snakebite...
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Pathomechanisms of cognitive and behavioral impairment in corticobasal degeneration
Corticobasal degeneration (CBD) is a rare, sporadic, late-onset progressive neurodegenerative disorder of unknown etiology, clinically characterized...
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Tau strains shape disease
Tauopathies consist of over 25 different neurodegenerative diseases that include argyrophilic grain disease (AGD), progressive supranuclear palsy...
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Progressive medial temporal degeneration with TDP-43 pathology is associated with upper limb and bulbar onset types of amyotrophic lateral sclerosis
ObjectiveThis study aimed to clarify the relationship between progressive medial temporal atrophy and onset subtype in patients with amyotrophic...
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Diagnostic performance of molecular imaging methods in predicting the progression from mild cognitive impairment to dementia: an updated systematic review
PurposeEpidemiological and logistical reasons are slowing the clinical validation of the molecular imaging biomarkers in the initial stages of...
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Incidental FOXL2 mutated adult granulosa cell tumour of the ovary with thecoma-like foci
We report on the incidental finding of a FOXL2 mutated adult granulosa cell tumour of the ovary with thecoma-like foci, a rare entity recently...
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Olfactory Neuroblastoma: Morphological Reappraisal and Molecular Insights with Quantum Leap in Clinical Perspectives
Purpose of ReviewThe purpose of review is to provide a comprehensive review of the literature focusing on the recent advances in the diagnosis,...
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Ultrastructural and biochemical classification of pathogenic tau, α-synuclein and TDP-43
Intracellular accumulation of abnormal proteins with conformational changes is the defining neuropathological feature of neurodegenerative diseases....
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Characterization of hippocampal sclerosis of aging and its association with other neuropathologic changes and cognitive deficits in the oldest-old
Hippocampal sclerosis of aging (HS-A) is a common age-related neuropathological lesion characterized by neuronal loss and astrogliosis in subiculum...
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Patterns of neuronal Rhes as a novel hallmark of tauopathies
The farnesyltransferase inhibitor, Lonafarnib, reduces tau inclusions and associated atrophy in familial tauopathy models through activation of...
