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Neurobehavioral Outcomes of Children with Antenatal Exposure to Antiseizure Medications
ObjectivesTo evaluate the effect of antiepileptic medications prescribed to mothers during pregnancy on the development and behavior of children.
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Thromboembolic Risks with Concurrent Direct Oral Anticoagulants and Antiseizure Medications: A Population-Based Analysis
Background and ObjectiveDrug–drug interactions between direct oral anticoagulants (DOAC) and antiseizure medications via the cytochrome P450 (CYP) or...
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Interactions Between Direct Oral Anticoagulants (DOACs) and Antiseizure Medications: Potential Implications on DOAC Treatment
The use of direct oral anticoagulants (DOACs) is increasing because of their superior efficacy and safety compared with vitamin K antagonists....
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Sex Differences in Adverse Effects of Antiseizure Medications in Adults with Epilepsy: A Systematic Review
BackgroundSex differences in epilepsy have been described in prevalence, seizure propensity and response to treatment. Therefore, taking into account...
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Newer Antiseizure Medications and Suicidality: Analysis of the Food and Drug Administration Adverse Event Reporting System (FAERS) Database
BackgroundThe association between antiseizure medications (ASMs) and suicidality remains controversial. Analyses of additional datasets are needed to...
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Antiseizure medications for idiopathic generalized epilepsies: a systematic review and network meta-analysis
ObjectivesTo compare the efficacy and safety of antiseizure medications (ASMs), both as monotherapies and adjunctive therapies, for idiopathic...
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The Effect of Levetiracetam Compared with Enzyme-Inducing Antiseizure Medications on Apixaban and Rivaroxaban Peak Plasma Concentrations
Background and ObjectivePost-stroke epilepsy represents an important clinical challenge as it often requires both treatment with direct oral...
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Efficacy and Safety of Five Broad-Spectrum Antiseizure Medications for Adjunctive Treatment of Refractory Epilepsy: A Systematic Review and Network Meta-analysis
BackgroundOverall, up to one-third of epilepsy patients have drug-resistant epilepsy. However, there was previously no meta-analysis to support the...
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Pilot study on the probability of drug-drug interactions among direct oral anticoagulants (DOACs) and antiseizure medications (ASMs): a clinical perspective
Abstract BackgroundThere is little and controversial information about changes in plasma concentrations (PCs) or clinical events during...
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Impact of Antiseizure Medications on Appetite and Weight in Children
There are numerous potential factors that may affect growth in children with epilepsy, and these must be evaluated in any child with appetite and...
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Efficacy and Tolerability of Adjunctive Brivaracetam in Patients with Focal-Onset Seizures on Specific Concomitant Antiseizure Medications: Pooled Analysis of Double-Blind, Placebo-Controlled Trials
IntroductionThis article aimed to assess the efficacy and tolerability of adjunctive brivaracetam (BRV) in adults with focal-onset seizures on...
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A pilot study on identifying gene signatures as markers for predicting patient response to antiseizure medications
The majority of the biomarkers were associated with the diagnosis of epilepsy and few of them can be applied to predict the response to antiseizure...
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A Review of the Selected and Newer Antiseizure Medications Used in Childhood Epilepsies
There have been additions of newer antiseizure medications in the armamentarium of clinicians for the management of epilepsy. The newer antiseizure...
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Adverse Event Profiles of Antiseizure Medications and the Impact of Coadministration on Drug Tolerability in Adults with Epilepsy
BackgroundAntiseizure medication (ASM) as monotherapy or in combination is the treatment of choice for most patients with epilepsy. Therefore,...
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Dose Adjustment of Concomitant Antiseizure Medications During Cenobamate Treatment: Expert Opinion Consensus Recommendations
IntroductionOur objective was to provide expert consensus recommendations to improve treatment tolerability through dose adjustments of concomitant...
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Incidence of Acute Renal Failure in Patients Using Levetiracetam Versus Other Antiseizure Medications: A Voluntary Post-Authorization Safety Study
IntroductionAcute kidney injury is an expected adverse drug reaction listed in the European Union (EU) Summary of Product Characteristics (SmPC) for...
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Pregnancy, folic acid, and antiseizure medication
BackgroundAlthough some antiseizure medications (ASMs) are teratogenic, most people with epilepsy need treatment in pregnancy. The risk of ASM...
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Clinically Relevant Interactions Between Ritonavir-Boosted Nirmatrelvir and Concomitant Antiseizure Medications: Implications for the Management of COVID-19 in Patients with Epilepsy
Ritonavir-boosted nirmatrelvir (RBN) has been authorized recently in several countries as an orally active anti-SARS-CoV-2 treatment for patients at...
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Psychiatric implications of anti-seizure medications in epileptic population
Background and objectiveEpilepsy is a prevalent neurological disorder that affects a significant number of individuals globally. This condition is...