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Changes of Mycobacterium tuberculosis specific antigen-stimulated CD27−CD38+IFN-γ+CD4+ T cells before and after anti-tuberculosis treatment
BackgroundThe aim of the study was to investigate whether the expression of CD27 − CD38 + in interferon (IFN)-γ + CD4 + T cells stimulated by the specific...
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Characterization of multiple soluble immune checkpoints in individuals with different Mycobacterium tuberculosis infection status and dynamic changes during anti-tuberculosis treatment
BackgroundImmune checkpoints are crucial for the maintenance of subtle balance between self-tolerance and effector immune responses, but the role of...
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Prevalence of vitamin D deficiency and the effect of vitamin D3 supplementation on response to anti-tuberculosis therapy in patients with extrapulmonary tuberculosis
BackgroundWe aimed to assess serum 25-hydroxyvitamin D3 (25(OH)D3) concentrations in extrapulmonary tuberculosis (EPTB) patients and to evaluate the...
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A case of paradoxical response during anti-tuberculosis treatment in a patient with ulcerative colitis
Emerging anti-tumor necrosis factor (TNF)-α antibodies therapy changed treatment strategy to inflammatory bowel diseases because of the efficacy....
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Efficacy of anterior debridement and bone grafting with fusion using internal fixation combined with anti-tuberculosis chemotherapy in the treatment of subaxial cervical tuberculosis
BackgroundTo evaluate the efficacy of anterior debridement and bone grafting with fusion using internal fixation (BFIF) combined with...
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Key factors influencing multidrug-resistant tuberculosis in patients under anti-tuberculosis treatment in two centres in Burundi: a mixed effect modelling study
BackgroundDespite the World Health Organization efforts to expand access to the tuberculosis treatment, multidrug resistant tuberculosis (MDR-TB)...
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Resuming anti-TNF therapy after development of miliary tuberculosis in Behcet’s disease-related uveitis: a case report
PurposeThere is no consensus concerning restarting anti-tumour necrosis factor (TNF)-α therapy for uveitis after treatment for active tuberculosis...
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Tuberculosis dissemination in kidney transplant recipient treated with anti-CD40 monoclonal antibody: a case report
BackgroundTuberculosis (TBC) in solid organ transplant recipients represents a severe complication. The incidence among transplant recipients is...
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Assessment of anti-PD-(L)1 for patients with coexisting malignant tumor and tuberculosis classified by active, latent, and obsolete stage
BackgroundIt is not a rare clinical scenario to have patients presenting with coexisting malignant tumor and tuberculosis. Whether it is feasible to...
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Preparation, characterization, and in-vitro cytotoxicity of nanoliposomes loaded with anti-tubercular drugs and TGF-β1 siRNA for improving spinal tuberculosis therapy
BackgroundTuberculosis (TB) represents a bacterial infection affecting many individuals each year and potentially leading to death. Overexpression of...
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Treatment and pregnancy outcomes of pregnant women exposed to second-line anti-tuberculosis drugs in South Africa
BackgroundMulti-drug resistant and rifampicin-resistant tuberculosis (MDR/RR-TB) in pregnant women is a cause for concern globally; few data have...
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Impaired T-cell response to phytohemagglutinin (PHA) in tuberculosis patients is associated with high IL-6 plasma levels and normalizes early during anti-mycobacterial treatment
PurposeHuman tuberculosis is characterized by immunopathology that affects T-cell phenotype and functions. Previous studies found impaired T-cell...
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Determinants of stock-outs of first line anti-tuberculosis drugs: the case of public health facilities of Addis Ababa city administration health bureau, Addis Ababa, Ethiopia
BackgroundThe health sectors success has been determined by consistent and reasonably priced health commodities supply. Despite possible death from...
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Risk and characteristics of tuberculosis after anti-tumor necrosis factor therapy for inflammatory bowel disease: a hospital-based cohort study from Korea
BackgroundAnti-tumor necrosis factor (TNF) treatment for inflammatory bowel disease (IBD) increases the risk of tuberculosis (TB) infection. In the...
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Do patients attempt and succeed in quitting smoking during tuberculosis treatment? A prospective cohort study
BackgroundDespite a well-known relation between smoking tobacco and the tuberculosis epidemic, the factors associated with smoking cessation in...
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Level of and associated factors for non-adherence to anti-tuberculosis treatment among tuberculosis patients in Gamo Gofa zone, southern Ethiopia: cross-sectional study
BackgroundNon-adherence to anti-TB treatment is one of the crucial challenges in improving tuberculosis (TB) treatment outcomes and reducing...
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Hearing assessment and treatment outcome in ENT tuberculosis at a tertiary hospital in India
AimAn attempt has been made to observe the response of anti-Koch’s treatment and the effect of anti-Koch’s treatment on hearing in ENT tuberculosis...
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Tuberculosis-related serpiginous choroiditis: aggressive therapy with dual concomitant combination of multiple anti-tubercular and multiple immunosuppressive agents is needed to halt the progression of the disease
Background/purposeSerpiginous-like choroiditis is a rare immune-mediated sub-entity of tubercular uveitis with a usually deleterious outcome....
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Shortened Treatment Regimens for Drug Sensitive TB
Tuberculosis (TB) has remained a global health challenge despite the availability of effective anti-tubercular drugs and various treatment...