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Showing 1-13 of 13 results
  1. An update in the applications of exosomes in cancer theranostics: from research to clinical trials

    Exosomes are nanosized extracellular vesicles secreted by nearly all viable cells following the fusing of multivesicular bodies and the plasma...

    Kourosh Shahraki, Paria Ghasemi Boroumand, ... Roghayeh Sheervalilou in Journal of Cancer Research and Clinical Oncology
    Article 03 April 2023
  2. Dietary choline and sphingomyelin choline moiety intake and risk of colorectal cancer: a case-control study

    Introduction

    Phospholipids are possible favorable agents for colorectal cancer (CRC). Choline has been inversely related to CRC risk but findings are...

    Marta Rossi, Malak Khalifeh, ... Paolo Boffetta in European Journal of Clinical Nutrition
    Article 21 July 2023
  3. Extracellular vesicles in cancer — implications for future improvements in cancer care

    The sustained growth, invasion, and metastasis of cancer cells depend upon bidirectional cell–cell communication within complex tissue environments....

    Rong Xu, Alin Rai, ... Richard J. Simpson in Nature Reviews Clinical Oncology
    Article 23 May 2018
  4. Abstracts

    Article 23 August 2017
  5. Identification of latent biomarkers in hepatocellular carcinoma by ultra-deep whole-transcriptome sequencing

    There is an urgent need to identify biomarkers for hepatocellular carcinoma due to limited treatment options and the poor prognosis of this common...

    K-T Lin, Y-J Shann, ... C-Y F Huang in Oncogene
    Article 21 October 2013
  6. Generating Ceramide from Sphingomyelin by Alkaline Sphingomyelinase in the Gut Enhances Sphingomyelin-Induced Inhibition of Cholesterol Uptake in Caco-2 Cells

    Background

    Sphingomyelin (SM) is present in dietary products and cell plasma membranes. We previously showed that dietary SM inhibited cholesterol...

    Dan Feng, Lena Ohlsson, ... Rui-Dong Duan in Digestive Diseases and Sciences
    Article 16 April 2010
  7. Expression of Alkaline Sphingomyelinase in Yeast Cells and Anti-inflammatory Effects of the Expressed Enzyme in a Rat Colitis Model

    Alkaline sphingomyelinase (Alk-SMase) is a key enzyme in the intestinal tract for digestion of dietary sphingomyelin (SM), which generates lipid...

    David Andersson, Knut Kotarsky, ... Rui-Dong Duan in Digestive Diseases and Sciences
    Article 07 November 2008
  8. Ursolic acid inhibits the formation of aberrant crypt foci and affects colonic sphingomyelin hydrolyzing enzymes in azoxymethane-treated rats

    Ursolic acid (UA) is a pentacyclic triterpenoid, with anti-cancer and anti-inflammatory properties. Sphingomyelin (SM) hydrolysis generates lipid...

    David Andersson, Yajun Cheng, Rui-Dong Duan in Journal of Cancer Research and Clinical Oncology
    Article 29 June 2007
  9. Abstract

    Article 25 July 2009
  10. Human Meconium Contains Significant Amounts of Alkaline Sphingomyelinase, Neutral Ceramidase, and Sphingolipid Metabolites

    Intestinal alkaline sphingomyelinase (Alk-SMase) and neutral ceramidase may catalyze the hydrolysis of endogenous sphingomyelin (SM) and milk SM in...

    Rui-Dong Duan, Yajun Cheng, ... Åke Nilsson in Pediatric Research
    Article 01 January 2007
  11. Membrane breakdown in acute and chronic neurodegeneration: focus on choline-containing phospholipids

    Breakdown of cellular membranes is a characteristic feature of neuronal degeneration in acute (stroke) and chronic (senile dementia) neurological...

    Article 01 August 2000
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