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An update in the applications of exosomes in cancer theranostics: from research to clinical trials
Exosomes are nanosized extracellular vesicles secreted by nearly all viable cells following the fusing of multivesicular bodies and the plasma...
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Dietary choline and sphingomyelin choline moiety intake and risk of colorectal cancer: a case-control study
IntroductionPhospholipids are possible favorable agents for colorectal cancer (CRC). Choline has been inversely related to CRC risk but findings are...
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Extracellular vesicles in cancer — implications for future improvements in cancer care
The sustained growth, invasion, and metastasis of cancer cells depend upon bidirectional cell–cell communication within complex tissue environments....
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Identification of latent biomarkers in hepatocellular carcinoma by ultra-deep whole-transcriptome sequencing
There is an urgent need to identify biomarkers for hepatocellular carcinoma due to limited treatment options and the poor prognosis of this common...
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Generating Ceramide from Sphingomyelin by Alkaline Sphingomyelinase in the Gut Enhances Sphingomyelin-Induced Inhibition of Cholesterol Uptake in Caco-2 Cells
BackgroundSphingomyelin (SM) is present in dietary products and cell plasma membranes. We previously showed that dietary SM inhibited cholesterol...
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Expression of Alkaline Sphingomyelinase in Yeast Cells and Anti-inflammatory Effects of the Expressed Enzyme in a Rat Colitis Model
Alkaline sphingomyelinase (Alk-SMase) is a key enzyme in the intestinal tract for digestion of dietary sphingomyelin (SM), which generates lipid...
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Ursolic acid inhibits the formation of aberrant crypt foci and affects colonic sphingomyelin hydrolyzing enzymes in azoxymethane-treated rats
Ursolic acid (UA) is a pentacyclic triterpenoid, with anti-cancer and anti-inflammatory properties. Sphingomyelin (SM) hydrolysis generates lipid...
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Human Meconium Contains Significant Amounts of Alkaline Sphingomyelinase, Neutral Ceramidase, and Sphingolipid Metabolites
Intestinal alkaline sphingomyelinase (Alk-SMase) and neutral ceramidase may catalyze the hydrolysis of endogenous sphingomyelin (SM) and milk SM in...
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Membrane breakdown in acute and chronic neurodegeneration: focus on choline-containing phospholipids
Breakdown of cellular membranes is a characteristic feature of neuronal degeneration in acute (stroke) and chronic (senile dementia) neurological...