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Aggregate index of systemic inflammation (AISI) in admission as a reliable predictor of mortality in COPD patients with COVID-19
BackgroundThe role of leukocytes and systemic inflammation indicators in predicting the severity and mortality of inflammatory diseases has been well...
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Impact of structural biology and the protein data bank on us fda new drug approvals of low molecular weight antineoplastic agents 2019–2023
Open access to three-dimensional atomic-level biostructure information from the Protein Data Bank (PDB) facilitated discovery/development of 100% of...
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Whole-exome sequencing in patients with protein aggregate myopathies reveals causative mutations associated with novel atypical phenotypes
BackgroundMyofibrillar myopathies (MFM) are a subgroup of protein aggregate myopathies (PAM) characterized by a common histological picture of...
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Extracellular protein homeostasis in neurodegenerative diseases
The protein homeostasis (proteostasis) system encompasses the cellular processes that regulate protein synthesis, folding, concentration, trafficking...
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Aberrant protein aggregation in amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a fatal disease. As its pathological mechanisms are not well understood, there are no efficient therapeutics...
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Nutritional Quality and Biological Application of Mushroom Protein as a Novel Protein Alternative
Purpose of ReviewGlobal concerns about population growth, economic, and nutritional transitions and health have led to the search for a low-cost...
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Novel polymorphisms in the prion protein gene (PRNP) and stability of the resultant prion protein in different horse breeds
Prion diseases are fatal neurodegenerative disorders in which the main pathogenic event is the conversion of the cellular prion protein (PrP C ) into...
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Protein sequence analysis in the context of drug repurposing
MotivationDrug repurposing speeds up the development of new treatments, being less costly, risky, and time consuming than de novo drug discovery....
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Prediction of clinical progression in nervous system diseases: plasma glial fibrillary acidic protein (GFAP)
Glial fibrillary acidic protein (GFAP), an intracellular type III intermediate filament protein, provides structural support and maintains the...
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C-reaktives Protein (CRP) – ein diagnostischer Entzündungsmarker am Beispiel ausgewählter Indikationen
In the series “Biomarkers” published in the Zentralblatt für Arbeitsmedizin, Arbeitsschutz und Ergonomie , C‑reactive protein (CRP) belongs as...
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Cleavage site-directed antibodies reveal the prion protein in humans is shed by ADAM10 at Y226 and associates with misfolded protein deposits in neurodegenerative diseases
Proteolytic cell surface release (‘shedding’) of the prion protein (PrP), a broadly expressed GPI-anchored glycoprotein, by the metalloprotease...
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Ras protein abundance correlates with Ras isoform mutation patterns in cancer
Activating mutations of Ras genes are often observed in cancer. The protein products of the three Ras genes are almost identical. However, for...
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Protein lipidation in health and disease: molecular basis, physiological function and pathological implication
Posttranslational modifications increase the complexity and functional diversity of proteins in response to complex external stimuli and internal...
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Serum tau protein elevation in migraine: a cross-sectional case–control study
BackgroundMigraine is a disorder associated with neuropeptide release, pain and inflammation. Tau protein has recently been linked to inflammatory...
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Chronic administration of XBD173 ameliorates cognitive deficits and neuropathology via 18 kDa translocator protein (TSPO) in a mouse model of Alzheimer’s disease
Alzheimer’s disease (AD) is characterized by the accumulation of β-amyloid peptide (Aβ). It affects cognition and leads to memory impairment. The...
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Exploring mechanisms of protein influence on calcium oxalate kidney stone formation
Calcium oxalate monohydrate (COM) crystals are the primary constituent of most kidney stones, but urine proteins in stone matrix are believed to be...
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Establishment of chemically oligomerizable TAR DNA-binding protein-43 which mimics amyotrophic lateral sclerosis pathology in mammalian cells
One of the pathological hallmarks of amyotrophic lateral sclerosis (ALS) is mislocalized, cytosolic aggregation of TAR DNA-Binding Protein-43...
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Transmembrane protein 117 knockdown protects against angiotensin-II-induced cardiac hypertrophy
Mitochondrial dysfunction plays a critical role in the pathogenesis of pathological cardiac hypertrophy. Transmembrane protein 117 modulate...
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Characteristics of intracerebral haemorrhage associated with COVID-19: a systematic review and pooled analysis of individual patient and aggregate data
Background and purposeThere are very few studies of the characteristics and causes of ICH in COVID-19, yet such data are essential to guide...
