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Adenine model of chronic renal failure in rats to determine whether MCC950, an NLRP3 inflammasome inhibitor, is a renopreventive
BackgroundChronic renal failure (CRF) is defined by a significant decline in renal function that results in decreased salt filtration and inhibition...
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Effects of bisphosphonates and treadmill exercise on bone and kidney in adenine-induced chronic kidney disease rats
IntroductionThe increasing prevalence of osteoporosis and chronic kidney disease (CKD) due to the aging of society has highlighted the need for...
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Effects of furosemide and tadalafil in both conventional and nanoforms against adenine-induced chronic renal failure in rats
BackgroundChronic renal failure (CRF) is a progressive loss of renal function that lead to reduced sodium filtration and inappropriate suppression of...
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Neointimal hyperplasia in the inferior vena cava of adenine-induced chronic kidney disease rats with aortocaval fistulas
BackgroundThe failure of autologous arteriovenous fistulas (AVFs) occurs primarily due to stenosis in the anastomotic site, which is mainly related...
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A model of hemodialysis after acute kidney injury in rats
BackgroundAcute kidney injury (AKI) is frequent among critically ill patients. Renal replacement therapy (RRT) is often required to deal with severe...
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Chronic treatment of curcumin improves hepatic lipid metabolism and alleviates the renal damage in adenine-induced chronic kidney disease in Sprague-Dawley rats
BackgroundChronic kidney disease (CKD), including nephrotic syndrome, is a major cause of cardiovascular morbidity and mortality. The literature...
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Ultrastructural changes of vascular smooth muscle cells and resistance to vasospasm treatment in femoral arteries of an arteriosclerotic rat model
The objective of this study was to establish an animal model of arteriosclerosis for assessing vasospasm and to investigate the relationship between...
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Severe chronic kidney disease environment reduced calcium-sensing receptor expression in parathyroid glands of adenine-induced rats even without high phosphorus diet
BackgroundChronic kidney disease (CKD) disrupts mineral homeostasis and its main underlying cause is secondary hyperparathyroidism (SHPT). We...
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Oxidative Stress Enzyme NOX1 Is a New and Important Biomarker for Childhood Appendicitis?
Delayed appendicitis diagnosis may result in perforation and an increased risk of mortality. This study aimed to assess the diagnostic value of...
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Effect of iron administration on the aortic iron content and vascular calcification in phosphorus-loaded chronic kidney disease rats
BackgroundCardiovascular disease (CVD) is a major cause of morbidity and mortality in patients with chronic kidney disease (CKD) and could be related...
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Hydrogen sulfide prevents arterial medial calcification in rats with diabetic nephropathy
BackgroundArterial medial calcification (AMC) is associated with a high incidence of cardiovascular risk in patients with type 2 diabetes and chronic...
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Roxadustat improves renal osteodystrophy by dual regulation of bone remodeling
PurposeRenal osteodystrophy (ROD), a component of chronic kidney disease-mineral and bone disorder (CKD-MBD) can lead to bone loss increasing...
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Effects of lactulose on renal function and gut microbiota in adenine-induced chronic kidney disease rats
BackgroundConstipation is frequently observed in patients with chronic kidney disease (CKD). Lactulose is expected to improve the intestinal...
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Impacts of Inflammatory Cytokines Variants on Systemic Inflammatory Profile and COVID-19 Severity
BackgroundCytokine storm is known to impact the prognosis of coronavirus disease 2019 (COVID-19), since pro-inflammatory cytokine variants are...
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P2B001 (Extended Release Pramipexole and Rasagiline): A New Treatment Option in Development for Parkinson’s Disease
Despite levodopa’s superior efficacy in reducing the motor symptoms of Parkinson’s disease (PD), its risk to induce motor complications requires...
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NAD+ exhaustion by CD38 upregulation contributes to blood pressure elevation and vascular damage in hypertension
Hypertension is characterized by endothelial dysfunction and arterial stiffness, which contribute to the pathogenesis of atherosclerotic...
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Bilirubin-associated single nucleotide polymorphism (SNP) and respiratory health outcomes: a mendelian randomization study
BackgroundObservational studies have shown an association between higher bilirubin levels and improved respiratory health outcomes. Targeting higher...
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Vitamin C alleviates LPS-induced myocardial injury by inhibiting pyroptosis via the ROS-AKT/mTOR signalling pathway
BackgroundThe efficacy of vitamin C in sepsis remains controversial. Whether vitamin C can alleviate lipopolysaccharide (LPS)-induced myocardial...
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Blood biomarkers improve the prediction of prevalent and incident severe chronic kidney disease
BackgroundThe prevalence of chronic kidney disease (CKD) is high. Identification of cases with CKD or at high risk of develo** it is important to...
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Circulating eNAMPT as a biomarker in the critically ill: acute pancreatitis, sepsis, trauma, and acute respiratory distress syndrome
BackgroundNicotinamide phosphoribosyltransferase (NAMPT) exhibits dual functionality – as an intracellular enzyme regulating nicotinamide adenine...
