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Assessing the Cntnap2 knockout rat prepulse inhibition deficit through prepulse scaling of the baseline startle response curve
Many neurodevelopmental disorders, including autism spectrum disorder (ASD), are associated with changes in sensory processing and sensorimotor...
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A midbrain-reticulotegmental circuit underlies exaggerated startle under fear emotions
Exaggerated startle has been recognized as a core hyperarousal symptom of multiple fear-related anxiety disorders, such as post-traumatic stress...
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Involvement of the thalamic reticular nucleus in prepulse inhibition of acoustic startle
Thalamic reticular nucleus (TRN) is a group of inhibitory neurons surrounding the thalamus. Due to its important role in sensory information...
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The effects of changes in stimulus properties on acoustic stapedius reflex response: a systematic review
BackgroundThe acoustic stapedius reflex is formed by the contraction of the stapedius muscle in the middle ear cavity when a loud sound is given to...
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Robust and replicable measurement for prepulse inhibition of the acoustic startle response
Measuring animal behavior in the context of experimental manipulation is critical for modeling, and understanding neuropsychiatric disease. Prepulse...
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The Auditory Brainstem Response (ABR) Test, Supplementary to Behavioral Tests for Evaluation of the Salicylate-Induced Tinnitus
Tinnitus is a symptom of various disorders that affects the quality of life of millions people. Given the significance of the access to an objective...
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Optimum stimulus for eliciting masseter vestibular-evoked myogenic potential: a comparative exploration with three different acoustic stimuli
ObjectiveTo compare the EMG rectified amplitude, absolute latencies, interpeak interval, and Interaural asymmetry parameters of masseter...
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Emotional Processing and Maltreatment During Childhood as Factors of Vulnerability to Alcohol Abuse in Young Adults
Different studies suggest a strong association between childhood abuse and alcohol use disorders (AUDs). The modulation of the startle response has...
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The effects of the ethanol extract of Cordia myxa leaves on the cognitive function in mice
BackgroundCordia myxa L. (Boraginaceae) is widely distributed in tropical regions and it’s fruits, leaves and stem bark have been utilized in folk...
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Auditory Behavior in Adult-Blinded Mice
Cross-modal plasticity occurs when the function of remaining senses is enhanced following deprivation or loss of a sensory modality. Auditory neural...
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Stimulation of the ventromedial prefrontal cortex blocks the return of subcortically mediated fear responses
The ventromedial prefrontal cortex (vmPFC) mediates the inhibition of defensive responses upon encounters of cues, that had lost their attribute as a...
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MDMA treatment paired with a trauma-cue promotes adaptive stress responses in a translational model of PTSD in rats
MDMA (3,4-methylenedioxymethamphetamine), a synthetic ring-substituted amphetamine, combined with psychotherapy has demonstrated efficacy for the...
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Prospective longitudinal assessment of sensorimotor gating as a risk/resiliency factor for posttraumatic stress disorder
Little is understood about cognitive mechanisms that confer risk and resiliency for posttraumatic stress disorder (PTSD). Prepulse Inhibition (PPI)...
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Deep psychophysiological phenoty** of adolescents and adults with 22q11.2 deletion syndrome: a multilevel approach to defining core disease processes
Background22q11.2 deletion syndrome (22q11.2DS) is the most common chromosomal interstitial-deletion disorder, occurring in approximately 1 in 2000...
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Tics: neurological disorders determined by a deficit in sensorimotor gating processes
Tic related disorders affect 4–20% of the population, mostly idiopathic, can be grouped in a wide spectrum of severity, where the most severe end is...
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FKBP5 inhibitors modulate alcohol drinking and trauma-related behaviors in a model of comorbid post-traumatic stress and alcohol use disorder
Post-traumatic stress disorder (PTSD) leads to enhanced alcohol drinking and development of alcohol use disorder (AUD). Identifying shared neural...
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Pleasant touch perception in borderline personality disorder and its relationship with disturbed body representation
BackgroundBorderline personality disorder (BPD) is characterized by altered perception of affective stimuli, including abnormal evaluation of...
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Repeated low doses of psilocybin increase resilience to stress, lower compulsive actions, and strengthen cortical connections to the paraventricular thalamic nucleus in rats
Psilocybin (a classic serotonergic psychedelic drug) has received appraisal for use in psychedelic-assisted therapy of several psychiatric disorders....
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Behavioral and brain reactivity to uncertain stress prospectively predicts binge drinking in youth
Prior studies show that individuals with alcohol use disorder exhibit exaggerated behavioral and brain reactivity to uncertain threats (U-threat). It...
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Noise-Induced Hypersensitization of the Acoustic Startle Response in Larval Zebrafish
Overexposure to loud noise is known to lead to deficits in auditory sensitivity and perception. We studied the effects of noise exposure on...
