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New thiophene derivative augments the antitumor activity of γ-irradiation against colorectal cancer in mice via anti-inflammatory and pro-apoptotic pathways
BackgroundColorectal cancer (CRC) is one of the most common types of cancer worldwide and the second cause of cancer-related deaths. It usually...
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Letter on “Role of gut microbiome in immune regulation and immune checkpoint therapy of colorectal cancer”
Investigations that decipher the human microbiome have reformed the way medicine is focusing on bacteria. An interesting research review recently...
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Differences Between the Intestinal Lumen Microbiota of Aberrant Crypt Foci (ACF)-Bearing and Non-bearing Rats
BackgroundMultiple factors including host–microbiota interaction could contribute to the conversion of healthy mucosa to sporadic precancerous...
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Inflammatory/juvenile-like polyps in neurofibromatosis type 1 associated with epithelial dysplasia
The term “juvenile-like (inflammatory/hyperplastic) mucosal polyps” (JLIHMP) has been recently introduced to describe a spectrum of polypoid lesions...
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Greasing the Wheels of Pharmacotherapy for Colorectal Cancer: the Role of Natural Polyphenols
Purpose of ReviewThe main purpose of this review, mainly based on preclinical studies, is to summarize the pharmacological and biochemical evidence...
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Review of Animal Models of Colorectal Cancer in Different Carcinogenesis Pathways
Colorectal cancer (CRC) is a common malignant tumor of the gastrointestinal tract with increasing morbidity and mortality. Exploring the factors...
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An unanticipated tumor-suppressive role of the SUMO pathway in the intestine unveiled by Ubc9 haploinsufficiency
Sumoylation is an essential posttranslational modification in eukaryotes that has emerged as an important pathway in oncogenic processes. Most human...
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Tumor initiation and early tumorigenesis: molecular mechanisms and interventional targets
Tumorigenesis is a multistep process, with oncogenic mutations in a normal cell conferring clonal advantage as the initial event. However, despite...
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Dietary choline and sphingomyelin choline moiety intake and risk of colorectal cancer: a case-control study
IntroductionPhospholipids are possible favorable agents for colorectal cancer (CRC). Choline has been inversely related to CRC risk but findings are...
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Evidence for Anticancer Effects of Chinese Medicine Monomers on Colorectal Cancer
Colorectal cancer is one of the most commonly occurring cancers worldwide. Although clinical reports have indicated the anticancer effects of Chinese...
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Understanding the regulation of β-catenin expression and activity in colorectal cancer carcinogenesis: beyond destruction complex
Aberrant Wnt/β-catenin signaling is central to colorectal cancer carcinogenesis. The well-known potential of targeting the canonical Wnt signaling...
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Antitumor activity of 5-fluorouracil polymeric nanogel synthesized by gamma radiation on a rat model of colon carcinoma: a proposed mechanism
The use of 5-fluorouracil (5-FU) is associated with multifaceted challenges and poor pharmacokinetics. Accordingly, our study was designed to prepare...
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Therapeutic potential of ginger bio-active compounds in gastrointestinal cancer therapy: the molecular mechanism
The scientific literature indicates that ginger is known for its medicinal properties from ancient times. Ginger is an excellent source of bio-active...
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Importance of sessile serrated lesions in a patient with familial adenomatous polyposis
A 28-year-old male visited hospital because his mother had been diagnosed with familial adenomatous polyposis (FAP) with a pathological variant of...
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Chemopreventive effect of Callistemon citrinus (Curtis) Skeels against colon cancer induced by 1,2-dimethylhydrazine in rats
PurposeCallistemon citrinus (Curtis) Skeels is a shrub native of Australia. In spite of containing an important number of bioactive compounds...
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Genomic landscape of colorectal carcinogenesis
PurposeThe molecular pathogenesis of solid tumour was first assessed in colorectal cancer (CRC). To date, ≤ 100 genes with somatic alterations have...
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Metformin increases pathological responses to rectal cancers with neoadjuvant chemoradiotherapy: a systematic review and meta-analysis
BackgroundTo summarize the chemo-radio effect of metformin in rectal cancers with neoadjuvant chemoradiotherapy on pathological response, tumor...
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Young-onset colorectal cancer
In the past decades the incidence of colorectal cancer (CRC) in people under the age of 50 years has increased, which is referred to as early-onset...
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Anticancer acumens of three Annona species: a proportional review
IntroductionCumulative pattern of cancer could be seen in day-to-day life with each passing year and, it is becoming a great matter of concern...
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A review of anti-tumour effects of Ganoderma lucidum in gastrointestinal cancer
Gastrointestinal (GI) cancer is the most common cancer in the world and one of the main causes of cancer-related death. Clinically, surgical excision...
