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Genetic heterogeneity in epilepsy and comorbidities: insights from Pakistani families
BackgroundEpilepsy, a challenging neurological condition, is often present with comorbidities that significantly impact diagnosis and management. In...
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EANM practice guidelines for an appropriate use of PET and SPECT for patients with epilepsy
Epilepsy is one of the most frequent neurological conditions with an estimated prevalence of more than 50 million people worldwide and an annual...
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Real-world evidence of epidemiology, patient characteristics, and mortality in people with drug-resistant epilepsy in the United Kingdom, 2011–2021
BackgroundA third of people with epilepsy are drug resistant. People with drug-resistant epilepsy (DRE) have a higher risk of mortality and physical...
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Epilepsy associated with cerebral cavernous malformations managed with stereotactic radiosurgery: an international, multicenter study
ObjectiveStereotactic radiosurgery (SRS) has been proposed as an alternative to resection for epilepsy control in patients with cerebral cavernous...
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Consensus on pediatric epilepsy surgery for young children: an investigation by the China Association Against Epilepsy task force on epilepsy surgery
Researchers have widely acknowledged the therapeutic value of epilepsy surgery for drug-resistant epilepsy. Nonetheless, there is a substantial gap...
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High-precision stereotactic irradiation for focal drug-resistant epilepsy versus standard treatment: a randomized waitlist-controlled trial (the PRECISION trial)
IntroductionThe standard treatment for patients with focal drug-resistant epilepsy (DRE) who are not eligible for open brain surgery is the...
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Long-term follow-up of vagus nerve stimulation in drug-resistant KCNT1-related epilepsy: a case presentation
BackgroundThe KCNT1 gene encodes a Na + -activated K + channel. Gain-of-function mutations of KCNT1 lead to autosomal dominant sleep-related hypermotor...
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Rapid switching from levetiracetam to brivaracetam in pharmaco-resistant epilepsy in people with and without intellectual disabilities: a naturalistic case control study
BackgroundApproximately one quarter of people with an intellectual disability (PwID) have epilepsy of whom nearly three-quarters are...
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Effect of Cenobamate on Cognition in Patients with Drug-Resistant Epilepsy with Focal Onset Seizures: An Exploratory Study
Background and ObjectiveMost second and third generation antiseizure medications (ASMs) are associated with cognitive adverse events, which are a...
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Is intraoperative electrocorticography (ECoG) for long-term epilepsy-associated tumors (LEATs) more useful in children?—A Randomized Controlled Trial
ObjectivesThe utility of intraoperative electrocorticography (ECoG)-guided resective surgery for pediatric long-term epilepsy-associated tumors...
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Long-term evolution and prognostic factors of epilepsy in limbic encephalitis with LGI1 antibodies
ObjectiveTo characterize the evolution of epilepsy in patients with leucine-rich glioma inactivated 1 antibody-associated (LGI1ab) limbic...
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Epilepsy in Asian countries
Epilepsy affects 50 million people worldwide. Nearly 80% of people with epilepsy live in resource-constrained low-income and middle-income countries....
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The effect of lacosamide monotherapy on sleep architecture in patients with epilepsy: a preliminary evidence
Lacosamide (LCM) is a third-generation antiseizure medication (ASM), and its effect on sleep architecture was supported by a few studies in patients...
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Effective treatment of NR2F1-related epilepsy with perampanel
BackgroundNR2F1 mutations are associated with Bosch-Boonstra-Schaaf optic atrophy syndrome (BBSOAS). Although ~ 46.7% of BBSOAS patients present...
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Re-evaluating the placebo response in recent canine dietary epilepsy trials
The placebo response is a common phenomenon. Limited evidence is available about its magnitude in canine epilepsy trials, even though it can...
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Breath-Hold-Triggered BOLD fMRI in Drug-Resistant Nonlesional Focal Epilepsy—A Pilot Study
PurposeIndividuals with drug-resistant epilepsy may benefit from epilepsy surgery. In nonlesional cases, where no epileptogenic lesion can be...
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Insights into epileptogenesis from post-traumatic epilepsy
Post-traumatic epilepsy (PTE) accounts for 5% of all epilepsies. The incidence of PTE after traumatic brain injury (TBI) depends on the severity of...
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The phenotypic spectrum of epilepsy associated with periventricular nodular heterotopia
BackgroundPeriventricular nodular heterotopia (PVNH) is a congenital brain malformation often associated with seizures. We aimed to clarify the...
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Mood disorders in adults with epilepsy: a review of unrecognized facts and common misconceptions
Epilepsy is one of the most common neurologic conditions. Its clinical manifestations are not restricted to seizures but often include cognitive...
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Drug resistant epilepsy and associated factors among children with epilepsies in Tanzania: a cross-sectional study
BackgroundEpilepsy contributes to high morbidity among children and adolescents in develo** countries. A quarter of all children with epilepsy will...
