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Early pathophysiology-driven airway pressure release ventilation versus low tidal volume ventilation strategy for patients with moderate-severe ARDS: study protocol for a randomized, multicenter, controlled trial
BackgroundConventional Mechanical ventilation modes used for individuals suffering from acute respiratory distress syndrome have the potential to...
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FX06 to rescue SARS-CoV-2-induced acute respiratory distress syndrome: a randomized clinical trial
BackgroundVascular leakage is a major feature of acute respiratory distress syndrome (ARDS). We aimed to evaluate the efficacy of FX06, a drug under...
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Maternal Characteristics and Outcomes Affected by COVID-19 Pandemic in Indonesia
AimCompare the impact of the intervention on the outcome of pregnancy of patients receiving obstetric care with and non-COVID-19 diagnosis at a...
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A reassessment about included studies and certainty of evidence on a systematic review and meta-analysis of steroid for patients with acute respiratory distress syndrome
We comment on the study by Hirano et al. about the effect of steroids in patients with acute respiratory distress syndrome. It might be necessary to...
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Awake self-proning for COVID-19 non-intubated patients—a single-centered experience
BackgroundCOVID-19 patients with respiratory failure may need intensive care unit (ICU) admission. Prone positioning in mechanically ventilated...
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Prognostic classification based on P/F and PEEP in invasively ventilated ICU patients with hypoxemia—insights from the MARS study
BackgroundOutcome prediction in patients with acute respiratory distress syndrome (ARDS) greatly improves when patients are reclassified based on...
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Compliance with antibiotic therapy guidelines in french paediatric intensive care units: a multicentre observational study
BackgroundBacterial infections (BIs) are widespread in ICUs. The aims of this study were to assess compliance with antibiotic recommendations and...
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Fluid management for sepsis-induced hypotension in patients with advanced chronic kidney disease: a secondary analysis of the CLOVERS trial
BackgroundEarly fluid management in patients with advanced chronic kidney disease (CKD) and sepsis-induced hypotension is challenging with limited...
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Grundlagen des notfallmedizinischen „Bridgings“ von kritisch kranken Patienten in der Notaufnahme bis zur Intensivstationsverlegung
The decision of the Federal Joint Committee (GBA) on a staged system of emergency structures in hospitals from 2018 stipulates that in hospitals with...
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Acute and Post-Acute COVID-19 Cardiovascular Complications: A Comprehensive Review
Purpose of ReviewThe risk of cardiovascular complications due to SARS-CoV-2 are significantly increased within the first 6 months of the infection....
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Radiological pulmonary sequelae after COVID-19 and correlation with clinical and functional pulmonary evaluation: results of a prospective cohort
ObjectivesWhether COVID-19 leads to long-term pulmonary sequelae or not remains unknown. The aim of this study was to assess the prevalence of...
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The positive impact of COVID-19 on critical care: from unprecedented challenges to transformative changes, from the perspective of young intensivists
Over the past 2 years, SARS-CoV-2 infection has resulted in numerous hospitalizations and deaths worldwide. As young intensivists, we have been at...
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Development of a repeated-measures predictive model and clinical risk score for mortality in ventilated COVID-19 patients
PurposeThe COVID-19 pandemic has caused intensive care units (ICUs) to reach capacities requiring triage. A tool to predict mortality risk in...
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Physiology dictated treatment after severe trauma: timing is everything
IntroductionDamage control strategies in resuscitation and (fracture) surgery have become standard of care in the treatment of severely injured...
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Management of COVID-19 ICU-survivors in primary care: - a narrative review
Many survivors of critical illness suffer from long-lasting physical, cognitive, and mental health sequelae. The number of affected patients is...
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Long-term renal outcomes of patients with COVID-19: a meta-analysis of observational studies
BackgroundKidney involvement is common in hospitalized coronavirus disease 2019 (COVID-19) patients during the acute phase, little is known about the...
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Hemodynamic dysfunction in neonatal sepsis
AbstractCardiovascular disturbances are a frequent occurrence in neonatal sepsis. Preterm and term infants are particularly vulnerable due to the...
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Cluster analysis unveils a severe persistent respiratory impairment phenotype 3-months after severe COVID-19
BackgroundThe mid-term respiratory sequelae in survivors of severe COVID-19 appear highly heterogeneous. In addition, factors associated with...
