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Showing 1-8 of 8 results

  1. Glial reactivity in a mouse model of beta-amyloid deposition assessed by PET imaging of P2X7 receptor and TSPO using [11C]SMW139 and [18F]F-DPA

    Background

    P2X7 receptor has emerged as a potentially superior PET imaging marker to TSPO, the gold standard for imaging glial reactivity. [ 11 C]SMW139...

    Obada M. Alzghool, Richard Aarnio, ... Merja Haaparanta-Solin in EJNMMI Research
    Article Open access 06 March 2024

  3. The P2X7 receptor tracer [11C]SMW139 as an in vivo marker of neuroinflammation in multiple sclerosis: a first-in man study

    Purpose

    The novel PET tracer [ 11 C]SMW139 binds with high affinity to the P2X 7 receptor, which is expressed on pro-inflammatory microglia. The...

    Marloes H. J. Hagens, Sandeep S. V. Golla, ... Adriaan A. Lammertsma in European Journal of Nuclear Medicine and Molecular Imaging
    Article Open access 08 November 2019

  4. Neuroinflammation Biomarkers in the AT(N) Framework Across the Alzheimer’s Disease Continuum

    In the past years, neuroinflammation has been widely investigated in Alzheimer’s disease (AD). Evidence from animal, in vivo and post-mortem studies...

    A. Bieger, A. Rocha, ... Eduardo R. Zimmer in The Journal of Prevention of Alzheimer's Disease
    Article 03 May 2023

  5. PET imaging of neuroinflammation: any credible alternatives to TSPO yet?

    Over the last decades, the role of neuroinflammation in neuropsychiatric conditions has attracted an exponentially growing interest. A key driver for...

    Fabien Chauveau, Alexandra Winkeler, ... Guillaume Becker in Molecular Psychiatry
    Article 13 July 2024

  6. Comprehensive review on design perspective of PET ligands based on β-amyloids, tau and neuroinflammation for diagnostic intervention of Alzheimer’s disease

    Purpose

    Alzheimer’s disease (AD) is a progressive neurodegenerative pathological condition that resulted from the deterioration of cholinergic neurons...

    Parul Mittal, Niharika Singh, ... Puja Panwar Hazari in Clinical and Translational Imaging
    Article 03 February 2021

  7. Advances in CNS PET: the state-of-the-art for new imaging targets for pathophysiology and drug development

    Purpose

    A limit on develo** new treatments for a number of central nervous system (CNS) disorders has been the inadequate understanding of the in...

    Stuart P. McCluskey, Christophe Plisson, ... Oliver Howes in European Journal of Nuclear Medicine and Molecular Imaging
    Article Open access 21 September 2019
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