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A dual-tracer approach using [11C]CH and [18F]FDG in HCC clinical decision making
BackgroundEarly detection of recurrent or progressive HCC remains the strongest prognostic factor for survival. Dual tracer PET/CT imaging with [ 11 C]...
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In-target production of [11C]CH4 from a nitrogen/hydrogen gas target as a function of beam current, irradiation time, and target temperature
BackgroundProduction of [ 11 C]CH 4 from gas targets is notorious for weak performance with respect to yield, especially when using high beam currents....
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Salt-wasting congenital adrenal hyperplasia phenotype as a result of the TNXA/TNXB chimera 1 (CAH-X CH-1) and the pathogenic IVS2-13A/C > G in CYP21A2 gene
BackgroundGenetic diversity of mutations in the CYP21A2 gene is the main cause of the monogenic congenital adrenal hyperplasia (CAH) disorder. On...
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Combined genotype of HCRTR2 and CLOCK variants in a large family of cluster headache with familial periodicity phenotype
PurposeCluster headache (CH) is a debilitating condition with severe and recurrent headaches characterized by circannual and circadian rhythms. A...
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Compartment-specific mutational landscape of clonal hematopoiesis
Clonal hematopoiesis (CH) is characterized by somatic mutations in blood cells of individuals without hematologic disease. While the mutational...
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Immunological, biochemical and pathological effects of vitamin C and Arabic gum co-administration on H9N2 avian influenza virus vaccinated and challenged laying Japanese quails
AimThis study evaluated the effect of co-administration of vitamin C and Arabic gum (AG) supplements on the response of vaccinated (VAC) and...
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The homozygous pathogenic variant of the POMGNT1 gene identified using whole-exome sequencing in Iranian family with congenital hydrocephalus
BackgroundHydrocephalus is one of the most common pathophysiological disabilities with a high mortality rate, which occurs both congenitally and...
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Development of superior chitosan–EDTA microparticles as an adsorbent base for solidifying the self-emulsifying drug delivery systems
BackgroundThe present study focused on develo** a superior adsorbent carrier (microparticles) to solidify the self-emulsifying drug delivery...
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Questionable advisability of vitamin and mineral dietary supplement use in adolescents
ObjectivePresent study aimed to assess potential health risk in Slovenian adolescents due to inadequate diet and/or dietary supplement (DS) use.
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Prediction of various insulin resistance indices for the risk of hypertension among military young adults: the CHIEF cohort study, 2014–2020
BackgroundNon-insulin-based insulin resistance (NI-IR) indices have been reported to have an association with prevalent hypertension, however, no...
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Screening of 23 candidate genes by next-generation sequencing of patients with permanent congenital hypothyroidism: novel variants in TG, TSHR, DUOX2, FOXE1, and SLC26A7
PurposeTo date, many genes have been associated with congenital hypothyroidism (CH). Our aim was to identify the mutational spectrum of 23 causative...
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Molecular characterization and phylogenetic analysis of porcine epidemic diarrhea virus strains circulating in China from 2020 to 2021
BackgroundPorcine epidemic diarrhea virus (PEDV), an enteric coronavirus, has become the major causative agent of acute gastroenteritis in piglets...
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Mutational screening of the TPO and DUOX2 genes in Argentinian children with congenital hypothyroidism due to thyroid dyshormonogenesis
PurposePrimary congenital hypothyroidism (CH) is the most common endocrine disease in children and one of the preventable causes of both cognitive...
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Clonal myelopoiesis promotes adverse outcomes in chronic kidney disease
We sought to determine the relationship between age-related clonal hematopoiesis (CH) and chronic kidney disease (CKD). CH, defined as mosaic...
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Chemotherapy periodization to maximize resistance training adaptations in oncology
IntroductionEngaging in exercise programs during cancer treatment is challenging due to the several chemotherapy-induced side effects. Using a...
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Improved synthesis of 6-bromo-7-[11C]methylpurine for clinical use
BackgroundMultidrug resistance-associated protein 1 (MRP1), an energy-dependent efflux pump, is expressed widely in various tissues and contributes...
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In vivo Study of a Newly Synthesized Chromen-4-one Derivative as an Antitumor Agent against HCC
BackgroundChromenes are a wide group of natural compounds that can be synthesized chemically. The chromen-4-one nucleus acts as a skeleton for...
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Evaluation of liver function in patients with chronic hepatitis B using Gd-EOB-DTPA-enhanced T1 map** at different acquisition time points: a feasibility study
PurposeThis study aimed to explore the impact of different acquisition times on the evaluation of liver function levels in chronic hepatitis B using...
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Impact of acute kidney injury on survival in patients with chronic hepatitis C: a retrospective cohort study
BackgroundAcute kidney injury (AKI) is expected to occur commonly in patients with chronic hepatitis C. In addition, AKI may affect the survival of...
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Surgical castration versus chemical castration in donkeys: response of stress, lipid profile and redox potential biomarkers
BackgroundCastration is a husbandry practice raising important questions on the welfare and physiological status of farm animals. Searching for...
