Search
Search Results
-
High levels of CRBN isoform lacking IMiDs binding domain predicts for a worse response to IMiDs-based upfront therapy in newly diagnosed myeloma patients
In recent years, the immunoderivative (IMiD) agents have been extensively used for the treatment of multiple myeloma (MM). IMiDs and their newer...
-
CLK1/SRSF5 pathway induces aberrant exon skip** of METTL14 and Cyclin L2 and promotes growth and metastasis of pancreatic cancer
BackgroundBoth aberrant alternative splicing and m6A methylation play complicated roles in the development of pancreatic cancer (PC), while the...
-
Circular RNA circCCNT2 is upregulated in the anterior cingulate cortex of individuals with bipolar disorder
Gene expression dysregulation in the brain has been associated with bipolar disorder, but little is known about the role of non-coding RNAs. Circular...
-
Identification and functional characterization of a hemizygous novel intronic variant in OCRL gene causes Lowe syndrome
BackgroundLowe syndrome is an X-linked multisystem disorder affecting eyes, nervous system, and kidney. The main causes are mutations in the OCRL ...
-
TCF7L2 acts as a molecular switch in midbrain to control mammal vocalization through its DNA binding domain but not transcription activation domain
Vocalization is an essential medium for social signaling in birds and mammals. Periaqueductal gray (PAG) a conserved midbrain structure is believed...
-
Genetic analysis of the PKHD1 gene with long-rang PCR sequencing
PKHD1 gene mutations are found responsible for autosomal recessive polycystic kidney disease (ARPKD). However, it is inconvenient to detect the...
-
Abnormal Indices of Cell Cycle Activity in Schizophrenia and their Potential Association with Oligodendrocytes
The goal of this study was to determine what signaling pathways may elicit myelin-specific gene expression deficits in schizophrenia (SZ). Microarray...
-
MAPT S305I mutation: implications for argyrophilic grain disease
Frontotemporal lobar degeneration (FTLD) with mutations in the tau gene (MAPT) causes familial frontotemporal dementia with tau pathology. Many of...
-
Complex MLL rearrangements in t(4;11) leukemia patients with absent AF4
· MLL fusion alleleThe human mixed lineage leukemia ( MLL) gene is frequently involved in genetic rearrangements with more than 55 different translocation partner genes,...
-
Untangling the human estrogen receptor gene structure
Awareness of estrogen's neuroprotective and behavioral effects is broadening rapidly and has served as an incentive to investigate estrogen...
-
Tau isoform profile and phosphorylation state in dementia pugilistica recapitulate Alzheimer's disease
Insights into mechanisms of familial Alzheimer's disease (AD) caused by genetic mutations have emerged rapidly compared to sporadic AD. Indeed,...
-
Distinct methylation patterns of two
APC gene promoters in normal and cancerous gastric epitheliaThe adenomatous polyposis coli (
APC ) tumor suppressor gene is mutationally inactivated in both familial and sporadic forms of colorectal cancers. In...
-
Screening for MLL tandem duplication in 387 unselected patients with AML identify a prognostically unfavorable subset of AML
Partial tandem duplications of the MLL gene have been associated with trisomy 11 in acute myeloid leukemia (AML) and recently, have also been...
