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Differential gene expression analysis using RNA sequencing: retinal pigment epithelial cells after exposure to continuous-wave and subthreshold micropulse laser
PurposeSubthreshold micropulse laser (SMPL) is more clinically efficient for the treatment of diabetic macular edema (DME) than the conventional...
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The regulation roles of miRNAs in Helicobacter pylori infection
Helicobacter pylori is a kind of Gram-negative bacteria that parasitizes on human gastric mucosa. Helicobacter pylori infection is very common in...
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Deconvoluting the Cells of the Human Heart with iPSC Technology: Cell Types, Protocols, and Uses
Purpose of ReviewInduced pluripotent stem cells (iPSCs) have become widely adopted tools in cardiovascular biology due to their ability to...
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Histamine Deficiency Promotes Myofibroblasts Transformation from HDC-Expressing CD11b+ Myeloid Cells in Injured Hearts Post Myocardial Infarction
Myocardial infarction (MI) is a significant contributor to the development of heart failure. Histidine decarboxylase (HDC), the unique enzyme that...
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Top Five Stories of the Cellular Landscape and Therapies of Atherosclerosis: Current Knowledge and Future Perspectives
Atherosclerosis (AS) is characterized by impairment and apoptosis of endothelial cells, continuous systemic and focal inflammation and dysfunction of...
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Unveiling the metabolic landscape of pulmonary hypertension: insights from metabolomics
Pulmonary hypertension (PH) is regarded as cardiovascular disease with an extremely poor prognosis, primarily due to irreversible vascular...
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A novel lncRNA ROPM-mediated lipid metabolism governs breast cancer stem cell properties
BackgroundCancer stem cells (CSCs) are considered as the major cause to tumor initiation, recurrence, metastasis, and drug resistance, driving poor...
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LGR6 activates the Wnt/β-catenin signaling pathway and forms a β-catenin/TCF7L2/LGR6 feedback loop in LGR6high cervical cancer stem cells
The leucine-rich repeat-containing G-protein-coupled receptor 6 (LGR6) is considered to be a stem cell marker in many normal tissues and promotes...
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Niclosamide downregulates LOX-1 expression in mouse vascular smooth muscle cells and changes the composition of atherosclerotic plaques in ApoE−/− mice
Genetic lineage tracing studies have shown that phenotypic switching of vascular smooth muscle cells (VSMCs) results in less-differentiated cells,...
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Machine learning and experimental validation to construct a metastasis-related gene signature and ceRNA network for predicting osteosarcoma prognosis
ObjectiveOsteosarcoma (OS) is more common in adolescents and significantly harmful, and the survival rate is considerably low, especially in patients...
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Lateral ventricle meningiomas in children: clinicopathological and neuroradiological features
PurposeLateral ventricle meningiomas (LVM) in children are very rare. The current research is mostly limited to adults, and there are very few...
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The roles of long noncoding RNA NEAT1 in cardiovascular diseases
The morbidity of cardiovascular diseases (CVDs) gradually increases worldwide. Long noncoding RNAs (lncRNAs) are a large class of...
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LDHA is a prognostic biomarker on the immune response in pancreatic adenocarcinoma and associated with m6A modification
PurposeN6-methyladenosine (m 6 A) is tightly associated with the progression of pancreatic ductal adenocarcinoma (PDAC). Another prominent feature of...
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The integrated multiomic diagnosis of sporadic meningiomas: a review of its clinical implications
IntroductionMeningiomas are generally considered “benign,” however, these tumors can demonstrate variability in behavior and a surprising...
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Role of repressed microRNAs in endometriosis
Endometriosis is a common, estrogen-dependent benign tumor that affect 3–10% women of reproductive age, and is characterized by the ectopic growth of...
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FNA of Meningioma with Rhabdoid Features Presenting as a Lateral Neck Mass
Primary meningioma at extracranial head and neck sites is uncommon. Since fine needle aspiration (FNA) is often the first line diagnostic modality...
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Unraveling the miRNA Puzzle in Atherosclerosis: Revolutionizing Diagnosis, Prognosis, and Therapeutic Approaches
Purpose of ReviewTo eradicate atherosclerotic diseases, novel biomarkers, and future therapy targets must reveal the burden of early atherosclerosis...
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A concise review on miRNAs as regulators of colon cancer stem cells and associated signalling pathways
Despite recent therapy advances and a better understanding of colon cancer biology, it remains one of the major causes of death. The cancer stem...
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Role of PPAR-related genes in chronic heart failure: evidence from large populations
BackgroundThe role of PPAR signaling and its associated genes in the pathogenesis and progression of chronic heart failure (CHF) remains elusive.
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Targeting deubiquitinase OTUB1 protects vascular smooth muscle cells in atherosclerosis by modulating PDGFRβ
Atherosclerosis is a chronic artery disease that causes various types of cardiovascular dysfunction. Vascular smooth muscle cells (VSMCs), the main...