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Molecular profile to guide personalized medicine in adult patients with primary brain tumors: results from the ProfiLER trial
Immunohistochemistry and recent molecular technologies progressively guided access to personalized anti-tumoral therapies. We explored the...
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Clinical and histopathological predictors of outcome in malignant meningioma
We investigated possible clinical and histopathological prognostic factors in a malignant meningioma cohort with comprehensive long-term...
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Endocan serum levels in patients with low- and high-grade meningiomas: does this biomarker have an indicative role?
BackgroundMeningiomas are one of the most common tumors of the brain and central nervous system. The key role of endocan in predicting tumor growth...
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Outcomes after gamma knife radiosurgery for intraventricular meningiomas
BackgroundIntraventricular meningiomas (IVMs) are rare tumors with considerable treatment-associated morbidity due to their challenging location....
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Multisystem ALK-positive histiocytosis: a multi-case study and literature review
BackgroundAnaplastic lymphoma kinase (ALK)-positive histiocytosis, a novel rare histiocytic proliferation, was first described in 2008; it occurs in...
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The integrated multiomic diagnosis of sporadic meningiomas: a review of its clinical implications
IntroductionMeningiomas are generally considered “benign,” however, these tumors can demonstrate variability in behavior and a surprising...
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Ki-67 labeling index predicts tumor progression patterns and survival in patients with atypical meningiomas following stereotactic radiosurgery
PurposeThis study investigated whether Ki-67 labeling index (LI) correlated with clinical outcomes after SRS for atypical meningiomas.
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Time optimization of gadobutrol-enhanced brain MRI for metastases and primary tumors using a dynamic contrast-enhanced imaging
BackgroundRecent advances in rapid imaging techniques necessitate the reconsideration of the optimal imaging delay time for contrast-enhanced...
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The epidemiology of primary and metastatic brain tumors in infancy through childhood
PurposeTo evaluate the epidemiology of primary and metastatic pediatric brain tumors in the United States according to the WHO CNS 4th and 5th...
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Capturing evolving definitions of 12 select rare CNS tumors: a timely report from CBTRUS and NCI-CONNECT
PurposeIncidence, prevalence, and survival are population-based statistics describing cancer burden. The National Cancer Institute’s (NCI)...
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Epithelioid inflammatory myofibroblastic sarcoma with VCL–ALK fusion of central nervous system: case report and brief review of the literature
Epithelioid inflammatory myofibroblastic sarcomas are an aggressive variant of inflammatory myofibroblastic tumor described primarily in the abdomen...
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Prognostic significance of brain invasion in meningiomas: systematic review and meta-analysis
The WHO 2016 classification introduced brain invasion as a standalone criterion for grade II meningioma (GIIM). We systematically reviewed studies...
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Towards machine learning-based quantitative hyperspectral image guidance for brain tumor resection
BackgroundComplete resection of malignant gliomas is hampered by the difficulty in distinguishing tumor cells at the infiltration zone. Fluorescence...
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Advanced MRI features of intraventricular inflammatory myofibroblastic tumor: a case report
BackgroundInflammatory myofibroblastic tumor (IMT) is a rare central nervous system (CNS) tumor. We first report a rare case of IMT in the lateral...
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Current status of SSR-directed imaging and therapy in meningioma
BackgroundMeningiomas are the most common tumours of the central nervous system in adults. In clinical routine, their diagnostic workup prior to...
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Oncogene-induced senescence in meningiomas—an immunohistochemical study
PurposeMeningiomas are tumours originating from meningothelial cells, the majority belonging to grade 1 according to the World Health Organization...
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The “Combo” radiotherapy treatment for high-risk grade 2 meningiomas: dose escalation and initial safety and efficacy analysis
PurposeThe subgroup “high-risk” WHO grade 2 (hRG2) meningiomas may benefit from adjuvant radiation therapy (RT), but results are still suboptimal...
