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Secondary IDH1 resistance mutations and oncogenic IDH2 mutations cause acquired resistance to ivosidenib in cholangiocarcinoma
The mutant IDH1 inhibitor ivosidenib improves outcomes for patients with IDH1- mutated cholangiocarcinoma, but resistance inevitably develops....
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Brentuximab vedotin resistance in classic Hodgkin's lymphoma and its therapeutic strategies: a review
BackgroundBone marrow cancer has been at the forefront of cancer research. The propensity of cancers to extravasate to the bone makes it a very...
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Causal relationship between insulin resistance and sarcopenia
Sarcopenia is a multifactorial disease characterized by reduced muscle mass and function, leading to disability, death, and other diseases. Recently,...
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Insulin resistance is a cardiovascular risk factor in hypertensive adults without type 2 diabetes mellitus
BackgroundMetabolic syndrome refers to the association among several cardiovascular risk factors: obesity, dyslipidemia, hyperglycemia, and...
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Application of impulse oscillometry to detect interstitial lung disease and airway disease in adults with rheumatoid arthritis
BackgroundWe conducted a retrospective observational study to explore the potential application of impulse oscillometry (IOS) as an alternative to...
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Insulin resistance in adipose tissue and metabolic diseases
Adipose tissue regulates systemic energy metabolism through adipokine production as well as energy storage and energy supply to other organs in...
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Gut microbiota in insulin resistance: a bibliometric analysis
BackgroundInsulin resistance (IR) is considered the pathogenic driver of diabetes, and can lead to obesity, hypertension, coronary artery disease,...
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Overcoming resistance to programmed cell death protein 1 (PD-1) blockade with allogeneic invariant natural killer T-cells (iNKT)
Gastric cancer is the 5 th most common malignancy worldwide with only 36% of patients with metastatic disease surviving beyond 5 years. Despite...
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Antimicrobial Resistance in Urinary Tract Infections
Purpose of ReviewThis review aims to summarize the recent literature regarding antimicrobial-resistant urinary tract infections in the United States...
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The association between hyperuricemia and insulin resistance surrogates, dietary- and lifestyle insulin resistance indices in an Iranian population: MASHAD cohort study
BackgroundPrevious studies have reported insulin resistance (IR) to be associated with hyperuricemia. In this study, we aimed to assess the possible...
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A multiparameter liquid biopsy approach allows to track melanoma dynamics and identify early treatment resistance
Melanoma heterogeneity is a hurdle in metastatic disease management. Although the advent of targeted therapy has significantly improved patient...
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Exceptional response to lorlatinib and cabozantinib in ROS1-rearranged NSCLC with acquired F2004V and L2086F resistance
Patients with ROS1-rearranged NSCLC demonstrate excellent disease control with ROS1-targeted therapy, but acquired resistance is inevitable. Of...
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Optimum Dose of Resistance Exercise for Cardiovascular Health and Longevity: Is More Better?
Purpose of ReviewAlthough there is extensive research on how much aerobic exercise to prescribe in order to reduce the risks of cardiovascular...
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Thyroid cancer and insulin resistance
Thyroid cancer has shown a parallel increase with diabetes in the last few years. This narrative review aims to explain the association between these...
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Rewiring of the N-Glycome with prostate cancer progression and therapy resistance
An understanding of the molecular features associated with prostate cancer progression (PCa) and resistance to hormonal therapy is crucial for the...
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Nanovaccines to combat drug resistance: the next-generation immunisation
BackgroundThe present review envisages the role of nanovaccines to combat the global challenges of antimicrobial resistance. Nanovaccines are a novel...
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Efficacy of rechallenge immunotherapy after immune monotherapy resistance in patients with advanced non-small cell lung cancer
PurposeDrug resistance inevitably occurs despite the encouraging results of immunotherapy. This study attempted to investigate immunotherapy...
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Clonal haematopoiesis, ageing and kidney disease
Clonal haematopoiesis of indeterminate potential (CHIP) is a preclinical condition wherein a sizeable proportion of an individual’s circulating blood...
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Molecular mechanism of MLCK1 inducing 5-Fu resistance in colorectal cancer cells through activation of TNFR2/NF-κB pathway
Background and aimsChemotherapy resistance in colorectal cancer have been faced with significant challenges in recent years. Particular interest is...
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Posttranslational splicing modifications as a key mechanism in cytarabine resistance in acute myeloid leukemia
Despite the approval of several drugs for AML, cytarabine is still widely used as a therapeutic approach. However, 85% of patients show resistance...
