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An Approach to Investigations of Chronic Liver Disease
Chronic liver disease (CLD) in children is more diverse compared to adults with respect to the etiology, progression and response to therapy. After...
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Choline supplementation mitigates effects of bilirubin in cerebellar granule neurons in vitro
BackgroundPremature infants may suffer from high levels of bilirubin that could lead to neurotoxicity. Bilirubin has been shown to decrease...
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Use of serum bilirubin/albumin ratio for early prediction of bilirubin induced neurological dysfunction
BackgroundKernicterus or bilirubin encephalopathy is a preventable cause of handicap, still occurs in our country. The aim of the current study was...
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Kernicterus Spectrum Disorders Diagnostic Toolkit: validation using retrospective chart review
BackgroundKernicterus Spectrum Disorders (KSDs) result from hyperbilirubinemia-induced brain injury. We developed a Toolkit (KSD-TK) to predict the...
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Hepatomegaly and fatty liver disease secondary to central hypothyroidism in combination with macrosomia as initial presentation of IGSF1 deficiency syndrome
PurposeIGSF1 deficiency syndrome (immunoglobulin superfamily member 1) is considered the most common sex-linked cause of secondary congenital...
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Os odontoideum and craniovertebral junction instability secondary to dystonia: case series and review of the literature
IntroductionOs odontoideum refers to a rounded ossicle detached from a hypoplastic odontoid process at the body of the axis. The aetiology has been...
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Normalizing hyperactivity of the Gunn rat with bilirubin-induced neurological disorders via ketanserin
BackgroundSevere neonatal hyperbilirubinemia has been known to cause the clinical syndrome of kernicterus and a milder one the syndrome of...
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Extreme neonatal hyperbilirubinemia, acute bilirubin encephalopathy, and kernicterus spectrum disorder in children with galactosemia
BackgroundGalactosemia has not been recognized as a cause of extreme neonatal hyperbilirubinemia, although growing evidence supports this association.
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Serum Bilirubin Concentrations and the Prevalence of Gilbert Syndrome in Elite Athletes
ObjectivesBilirubin is a potent endogenous antioxidant and immunomodulating substance, which is also implicated in both cell signalling and various...
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Efficacy of transcutaneous bilirubinometry as compared to serum bilirubin in preterm newborn during phototherapy
Transcutaneous measurement of bilirubin is being used for neonatal jaundice. Its utility during phototherapy in preterm babies is not established....
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Choline supplementation prevents the effects of bilirubin on cerebellar-mediated behavior in choline-restricted Gunn rat pups
BackgroundBilirubin is produced by the breakdown of hemoglobin and is normally catabolized and excreted. Neurotoxic accumulation of serum bilirubin...
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Assessment of Otoacoustic Emissions (OAE) in Birth Asphyxiated Neonates
One of the congenital abnormalities encountered in newborns is hearing loss. Birth hypoxia, asphyxia, and ischemia have all been implicated as...
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The effect of different intravenous lipids on free bilirubin levels in premature infants
BackgroundIntravenous lipid emulsions are commonly used as a part of parenteral nutrition in premature infants. The potential bilirubin-displacing...
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Transcutaneous bilirubin levels in extremely preterm infants less than 30 weeks gestation
ObjectiveThe primary objective of this study was to determine the relationship between transcutaneous bilirubin (TcB) levels and total serum...
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Combination of UGT1A1 polymorphism and baseline plasma bilirubin levels in predicting the risk of antipsychotic-induced dyslipidemia in schizophrenia patients
The prolonged usage of atypical antipsychotic drugs (AAPD) among individuals with schizophrenia often leads to metabolic side effects such as...
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A case report of a novel 22 bp duplication within exon 1 of the UGT1A1 in a Sudanese infant with Crigler-Najjar syndrome type I
BackgroundCrigler Najjar type 1 is a rare autosomal recessive condition caused by the absence of UDPGT enzyme due to mutations in the UGT1A1 gene....
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Dual Maternal Alloimmunization by Antibodies of Rhesus and MNSs Blood Group System: Case Series and Approach to Work Up in a Resource Limited Set Up
Backgrounds and ObjectivesMaternal alloimmunisation by non D Rh and non Rh antibodies leading to HDFN, is a well established problem encountered in...
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Review of bilirubin neurotoxicity I: molecular biology and neuropathology of disease
Despite the availability of successful prevention strategies to prevent excessive hyperbilirubinemia, the neurological sequelae of bilirubin...
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Bilirubin-associated single nucleotide polymorphism (SNP) and respiratory health outcomes: a mendelian randomization study
BackgroundObservational studies have shown an association between higher bilirubin levels and improved respiratory health outcomes. Targeting higher...
