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Achaete-scute complex-like 2 regulated inflammatory mechanism through Toll-like receptor 4 activating in stomach adenocarcinoma
BackgroundTo investigate the role of achaete-scute complex-like 2 (ASCL2) in stomach adenocarcinoma (STAD), we analyze whether ASCL2 suppression...
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Osteoprotegerin and RANKL-RANK-OPG-TRAIL signalling axis in heart failure and other cardiovascular diseases
Osteoprotegerin (OPG) is a glycoprotein involved in the regulation of bone remodelling. OPG regulates osteoclast activity by blocking the interaction...
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Dark-light cycle disrupts bone metabolism and suppresses joint deterioration in osteoarthritic rats
BackgroundLight alteration affects the internal environment and metabolic homeostasis of the body through circadian rhythm disorders (CRD). CRD is...
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Denosumab in the Treatment of Osteoporosis: 10 Years Later: A Narrative Review
The fully human monoclonal antibody denosumab was approved for treatment of osteoporosis in 2010 on the basis of its potent antiresorptive activity,...
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Expanding telmisartan’s therapeutic horizon: exploring its multifaceted mechanisms beyond cardiovascular disorders
BackgroundTelmisartan, a potent angiotensin II type-1 receptor blocker as well as partial PPAR–gamma agonist, has emerged as a versatile therapeutic...
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Estrogen-mediated downregulation of HIF-1α signaling in B lymphocytes influences postmenopausal bone loss
In the bone marrow, B cells and bone-resorbing osteoclasts colocalize and form a specific microenvironment. How B cells functionally influence...
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Association of TNF-α, IGF-1, and IGFBP-1 levels with the severity of osteopenia in mice with nonalcoholic fatty liver disease
BackgroundsNonalcoholic fatty liver disease (NAFLD) exhibits a close association with osteoporosis. This work aims to assess the potential effects of...
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Glucose variability: a new risk factor for cardiovascular disease
Aims and data synthesisGlucose variability (GV) is increasingly considered an additional index of glycemic control. Growing evidence indicates that...
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CD147 receptor is essential for TFF3-mediated signaling regulating colorectal cancer progression
Major gaps in understanding the molecular mechanisms of colorectal cancer (CRC) progression and intestinal mucosal repair have hampered therapeutic...
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Exploiting RIG-I-like receptor pathway for cancer immunotherapy
RIG-I-like receptors (RLRs) are intracellular pattern recognition receptors that detect viral or bacterial infection and induce host innate immune...
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RANKL as a therapeutic target of rheumatoid arthritis
Rheumatoid arthritis (RA) is an inflammatory disorder characterized by progressive joint destruction. Recent studies have demonstrated that...
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Carboxymethyl chitosan reduces inflammation and promotes osteogenesis in a rabbit knee replacement model
BackgroundThe major causes of failure after total knee arthroplasty (TKA) include prosthesis loosening and infection. This study aimed to investigate...
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Regulatory Effect of Osteocytes on Extramedullary and Bone Marrow Adipose Tissue Development and Function
Purpose of ReviewThis review summarizes evidence on osteocyte support of extramedullary and bone marrow adipocyte development and discusses the role...
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Isoflavones daidzin and daidzein inhibit lipopolysaccharide-induced inflammation in RAW264.7 macrophages
BackgroundInflammation contributes to various diseases and soybeans and legumes are shown to reduce inflammation. However, the bioactive ingredients...
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Bioinformatics-based Identification of Key Pathways and Hub Genes of Traumatic Brain Injury in a Rat Model
Traumatic brain injury (TBI) is a common injury caused by external forces that lead to damaged brain function or pathological changes in the brain...
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Value of serum osteoprotegerin in the assessment of endothelial dysfunction in obesity
ObjectiveOsteoprotegerin is a member of the tumor necrosis factor receptor superfamily. The study aimed to assess serum osteoprotegerin and...
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Salt and Gut Microbiota in Heart Failure
Purpose of ReviewThe role and underlying mechanisms mediated by dietary salt in modulating the gut microbiota and contributing to heart failure (HF)...
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Microbiota as the unifying factor behind the hallmarks of cancer
The human microbiota is a complex ecosystem that colonizes body surfaces and interacts with host organ systems, especially the immune system. Since...
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Increased thyroid stimulating hormone (TSH) as a possible risk factor for atherosclerosis in subclinical hypothyroidism
Primary hypothyroidism (PHT) is associated with an increased risk for the development of atherosclerosis (AS) and other cardiovascular disorders. PHT...
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Regulation of T cell-associated tissues and T cell activation by RANKL-RANK-OPG
The receptor activator of nuclear factor kappa-B ligand (RANKL)-RANK-osteoprotegerin (OPG) system is critical to bone homeostasis, but genetically...
