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Does the Addition of Intrathecal Baclofen Along with or After Soft-Tissue Hip Adductor Surgery Decrease the Need for Hip Reconstruction Compared with Soft-Tissue Surgery Alone for Children with Nonambulatory Cerebral Palsy?
PurposeIntrathecal baclofen (ITB) is a well-known treatment option for cerebral palsy (CP) spasticity. The combination of soft-tissue release and ITB...
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Systemic and intrathecal baclofen produce bladder antinociception in rats
BackgroundBaclofen, a clinically available GABA B receptor agonist, produces non-opioid analgesia in multiple models of pain but has not been tested...
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Effects of 5 µg/kg intrathecal morphine for postoperative analgesia in pediatric patients undergoing major surgery
BackgroundThe effects and analgesic adequacy of intrathecal morphine (ITM) administration have been studied less frequently than other regional...
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A prediction model using machine-learning algorithm for assessing intrathecal hyperbaric bupivacaine dose during cesarean section
BackgroundThe intrathecal hyperbaric bupivacaine dosage for cesarean section is difficult to predetermine. This study aimed to develop a...
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Characterization of standard work tools for intrathecal baclofen therapy
PurposeIntrathecal baclofen (ITB) has been an effective therapy since the 1980s, with widely reported revision, infection, and complication rates....
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Successful intrathecal neurolytic block for the management of cancer pain in a 10-year-old child: a case report
BackgroundCancer pain management in children is challenging owing to their unique patient characteristics. We present the case of a 10-year-old girl...
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Effects of intrathecal opioids on cesarean section: a systematic review and Bayesian network meta-analysis of randomized controlled trials
Purpose: We aimed to compare the beneficial and harmful effects of opioids used as adjuncts to local anesthetics in patients undergoing cesarean...
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Intrathecal baclofen therapy for severe spasticity in an adult with tethered cord syndrome: a case report
BackgroundPatients with tethered cord syndrome often suffer severe spasticity. To the best of our knowledge, intrathecal baclofen (ITB) therapy in a...
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Clinical effect of rectus sheath block compared to intrathecal morphine injection for minimally invasive colorectal cancer surgery: a propensity score–matched study
PurposeTo evaluate the postoperative outcomes of a multimodal perioperative pain management protocol with rectus sheath blocks (RSBs) or intrathecal...
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Postoperative hemodynamics after high spinal block with or without intrathecal morphine in cardiac surgical patients: a randomized-controlled trial
PurposeThere is some evidence for the use of intrathecal morphine as a means to provide prolonged analgesia in selective cardiac surgical patients;...
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Intrathecal morphine in combination with bupivacaine as pre-emptive analgesia in posterior lumbar fusion surgery: a retrospective cohort study
BackgroundThe purpose of this study was to evaluate the efficacy of intrathecal morphine (ITM) in combination with bupivacaine as pre-emptive...
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Gabapentin enhances the antinociceptive effect of intrathecal morphine in refractory cancer pain patients
PurposeMorphine infusion through Intrathecal Drug Delivery System (IDDS) is widely used to relieve refractory cancer pain. However, continuous...
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Magnesium sulfate intravenous infusion versus intrathecal injection for prevention of post-spinal shivering during lower limb fracture surgery: a randomized controlled study
Abstract BackgroundShivering is a prevalent adverse event after spinal anesthesia, often disturbing to medical staff and hazardous to patients....
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Off-label intrathecal use of gadobutrol: safety study and comparison of administration protocols
PurposeMagnetic resonance imaging (MRI) contrast agents have been used off-label for diagnosis of cerebrospinal fluid (CSF) leaks and lately also for...
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Intrathecal therapy for tuberculous meningitis: propensity-matched cohort study
ObjectiveThe study aimed to determine the safety and efficacy of intrathecally administered isoniazid (INH) and prednisolone in addition to systemic...
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Ultra-low radiation dose protocol for CT-guided intrathecal nusinersen injections for patients with spinal muscular atrophy and severe scoliosis
PurposeIntrathecal injection of nusinersen is an approved treatment of spinal muscular atrophy (SMA). CT-guided injection is a method of nusinersen...
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Morphine overinfusion of intrathecal drug administration system under magnetic resonance evaluation for the diagnosis of stroke: a case report
BackgroundUntil recently, it is generally considered safe to perform magnetic resonance imaging (MRI) in patients with an intrathecal drug...