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Ventricular remodeling and hemodynamic changes in heart failure patients with non-ischemic dilated cardiomyopathy following dapagliflozin initiation
BackgroundIn heart failure with reduced ejection fraction (HFrEF), sodium–glucose co-transporter inhibitors (SGLT-2i) have persistently shown...
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Left ventricular remodeling response to SGLT2 inhibitors in heart failure: an updated meta-analysis of randomized controlled studies
BackgroundRandomized controlled trials (RCTs) reported contrasting results about reverse left ventricular remodeling (LVR) after sodium-glucose...
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Functional and Metabolic Imaging in Heart Failure with Preserved Ejection Fraction: Promises, Challenges, and Clinical Utility
Heart failure with preserved ejection fraction (HFpEF) is recognised as an increasingly prevalent, morbid and burdensome condition with a poor...
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Myocardial Fatigue: a Mechano-energetic Concept in Heart Failure
Purpose of ReviewThis review combines existing mechano-energetic principles to provide a refreshing perspective in heart failure (HF) and examine if...
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Brain Metabolism and Structure in Chronic Migraine
Purpose of ReviewThe purpose of this paper is to review and synthesize current literature in which neurochemical and structural brain imaging were...
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Relationship of Physical Frailty to Phosphocreatine Recovery in Muscle after Mild Exercise Stress in the Oldest-Old Women
BackgroundPhysical frailty is a clinical syndrome associated with aging and manifesting as slowness, weakness, reduced physical activity, weight...
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Recurrent germline variant in ATM associated with familial myeloproliferative neoplasms
Genetic predisposition (familial risk) in the myeloproliferative neoplasms (MPNs) is more common than the risk observed in most other cancers,...
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Expressions of mitochondria-related genes in pregnant women with subclinical hypothyroidism, and expressions of miRNAs in maternal and cord blood
BackgroundSubclinical hypothyroidism in pregnancy and definition by upper thyrotropin (TSH) cutoff are controversial. As mitochondria are influenced...
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Recommendations for Women in Mountain Sports and Hypoxia Training/Conditioning
The (patho-)physiological responses to hypoxia are highly heterogeneous between individuals. In this review, we focused on the roles of sex...
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Glutamine stabilizes myc via alpha-ketoglutarate and regulates paclitaxel sensitivity
Metabolic reprogramming wherein the cancer cells exhibit altered energetics is a hallmark of cancer. Although recent discoveries have enhanced our...
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Skeletal Muscle Complications in Chronic Kidney Disease
Purpose of ReviewTo provide an overview of the recent literature investigating the pathophysiology of skeletal muscle changes, interventions for...
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A Conceptual Exploration of Hamstring Muscle–Tendon Functioning during the Late-Swing Phase of Sprinting: The Importance of Evidence-Based Hamstring Training Frameworks
An eccentrically lengthening, energy-absorbing, brake-driven model of hamstring function during the late-swing phase of sprinting has been widely...
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Iron deficiency and supplementation in heart failure
Non-anaemic iron deficiency (NAID) is a strategic target in cardiovascular medicine because of its association with a range of adverse effects in...
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Modeling Nonischemic Genetic Cardiomyopathies Using Induced Pluripotent Stem Cells
Purpose of ReviewThe advent of induced pluripotent stem cells (iPSC) has paved the way for new in vitro models of human cardiomyopathy. Herein, we...
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The influence of the windlass mechanism on kinematic and kinetic foot joint coupling
BackgroundPrevious research shows kinematic and kinetic coupling between the metatarsophalangeal (MTP) and midtarsal joints during gait. Studying the...
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Practical assessment of risk of VILI from ventilating power: a conceptual model
At the bedside, assessing the risk of ventilator-induced lung injury (VILI) requires parameters readily measured by the clinician. For this purpose,...
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Coordinated Metabolic Responses Facilitate Cardiac Growth in Pregnancy and Exercise
Purpose of ReviewPregnancy and exercise are systemic stressors that promote physiological growth of the heart in response to repetitive volume...
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Hemodynamic forces from 4D flow magnetic resonance imaging predict left ventricular remodeling following cardiac resynchronization therapy
BackgroundPatients with heart failure and left bundle branch block (LBBB) may receive cardiac resynchronization therapy (CRT), but current selection...
