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Vascular and pulmonary effects of ibuprofen on neonatal lung development
BackgroundIbuprofen is a nonsteroidal anti-inflammatory drug that is commonly used to stimulate closure of a patent ductus arteriosus (PDA) in very...
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Evaluation of a simultaneous adsorption device for cytokines and platelet–neutrophil complexes in vitro and in a rabbit acute lung injury model
BackgroundPlatelet–neutrophil complexes (PNCs) readily migrate into tissues and induce tissue damage via cytokine or other pathogenic factors...
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Molecular Mechanisms Underlying Systemic Sclerosis–Associated Interstitial Lung Disease and Idiopathic Pulmonary Fibrosis: an Update
Purpose of reviewSystemic sclerosis–associated interstitial lung disease (SSc-ILD) and idiopathic pulmonary fibrosis (IPF) are fatal fibrotic lung...
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Adenosine metabolized from extracellular ATP ameliorates organ injury by triggering A2BR signaling
BackgroundTrauma and a subsequent hemorrhagic shock (T/HS) result in insufficient oxygen delivery to tissues and multiple organ failure....
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Inhibitory effect of aspirin on inflammation-induced lung metastasis of cancer cells associated with neutrophil infiltration
PurposeSystematic inflammation has been reported to contribute to cancer progression through various mechanisms; however, the exact mechanism is...
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Targeted imaging of very late antigen-4 for noninvasive assessment of lung inflammation-fibrosis axis
BackgroundThe lack of noninvasive methods for assessment of dysregulated inflammation as a major driver of fibrosis (i.e., inflammation-fibrosis...
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Clinicopathological characteristics of kidney injury in non-small cell lung cancer patients under combination therapy including pembrolizumab
Combination therapy, consisting of immune checkpoint inhibitors and traditional chemotherapeutic agents, has significantly improved the clinical...
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Targeting neutrophils extracellular traps (NETs) reduces multiple organ injury in a COVID-19 mouse model
BackgroundCOVID-19 is characterized by severe acute lung injury, which is associated with neutrophil infiltration and the release of neutrophil...
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HIV-associated lung disease
Lung disease encompasses acute, infectious processes and chronic, non-infectious processes such as chronic obstructive pulmonary disease, asthma and...
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Nitrate attenuates cisplatin-induced acute kidney injury by promotion of mitophagy and reduction of oxidative stress
Cisplatin, an anticancer drug, has limited its clinical application due to its severe nephrotoxicity, such as acute kidney injury (AKI). Damaged or...
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Combination of pseudoephedrine and emodin ameliorates LPS-induced acute lung injury by regulating macrophage M1/M2 polarization through the VIP/cAMP/PKA pathway
BackgroundAcute lung injury (ALI) is an acute multifactorial infectious disease induced by trauma, pneumonia, shock, and sepsis. This study aimed to...
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Pharmacovigilance of nephrotoxic drugs in neonates: the Pottel method for acute kidney injury detection in ELBW neonates
BackgroundExtremely low birth weight (ELBW) neonates (birth weight ≤ 1000 g) are at high risk to develop drug-induced acute kidney injury (AKI)....
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Electroacupuncture Alleviate Lung Injury of Sepsis Through α7nAChR and NF-κB Signaling Pathway
BackgroundSepsis is the leading cause of death in hospitalized patients in the intensive care unit (ICU). Although substantial progress has been made...
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A New Aspect of Penehyclidine Hydrochloride in Alleviating Myocardial Ischemia–Reperfusion Injury: Ferroptosis
Penehyclidine hydrochloride (PHC) is an anticholinergic drug with cardioprotective effects. Ferroptosis is closely related to myocardial...
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Risk of drug-induced cardiac arrhythmia during COVID-19 therapeutic treatment
Therapeutic treatment of severe COVID-19 infection involves the administration of multiple pharmacologic agents to reduce the risk of serious...
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Caffeine and neonatal acute kidney injury
Acute kidney injury is one of the most threatening diseases in neonates, with complex pathogenesis and limited treatment options. Caffeine is a...
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A fully automated micro‑CT deep learning approach for precision preclinical investigation of lung fibrosis progression and response to therapy
Micro-computed tomography (µCT)-based imaging plays a key role in monitoring disease progression and response to candidate drugs in various animal...
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Lung molecular and histological changes in type 2 diabetic rats and its improvement by high-intensity interval training
BackgroundType 2 diabetes (T2D) leads to serious respiratory problems. This study investigated the effectiveness of high-intensity interval training...
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A case of crescentic glomerulonephritis induced by afatinib for lung adenocarcinoma
Afatinib is a second-generation, oral, epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI). One of the most common adverse effects...
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Acoustic radiation force impulse-induced lung hemorrhage: investigating the relationship with peak rarefactional pressure amplitude and mechanical index in rabbits
PurposeThe safety of acoustic radiation force impulse (ARFI) elastography, which applies higher acoustic power with a longer pulse duration (PD) than...
