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Tau filaments with the chronic traumatic encephalopathy fold in a case of vacuolar tauopathy with VCP mutation D395G
Dominantly inherited mutation D395G in the gene encoding valosin-containing protein causes vacuolar tauopathy, a type of behavioural-variant...
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Annexin A11 aggregation in FTLD–TDP type C and related neurodegenerative disease proteinopathies
TAR DNA-binding protein 43 (TDP-43) is an RNA binding protein found within ribonucleoprotein granules tethered to lysosomes via annexin A11. TDP-43...
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Age-related increase of monoamine oxidase B in amyloid-negative cognitively unimpaired elderly subjects
ObjectiveMonoamine oxidase B (MAO-B) is highly abundant in reactive astrocytes and upregulated in neuroinflammatory processes. However, the...
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Alterations in intra- and internetwork functional connectivity associated with levetiracetam treatment in temporal lobe epilepsy
ObjectiveLevetiracetam (LEV) is an antiepileptic drug with a novel pharmacological mechanism. Advances in functional magnetic resonance imaging...
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Yield of non-invasive imaging in MRI-negative focal epilepsy
ObjectiveThe absence of MRI-lesion reduces considerably the probability of having an excellent outcome (International League Against Epilepsies...
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Interobserver assessment of metabolic patterns in progressive primary aphasia through the application of [18F]-Fluorodeoxiglucose PET/CT
PurposeOur primary objective was to evaluate interobserver variability in [18 F]-FDG PET/CT image interpretation in Primary Progressive Aphasia...
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The role of histone modifications: from neurodevelopment to neurodiseases
Epigenetic regulatory mechanisms, including DNA methylation, histone modification, chromatin remodeling, and microRNA expression, play critical roles...
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Vasotocin receptor gene genotypes moderate the relationship between cortical thickness and sensory processing
Sensory processing is the process by which the central nervous system gathers, interprets, and regulates sensory stimuli in response to environmental...
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Process approach as a cognitive biomarker related to gray matter volume in mild cognitive impairment and Alzheimer’s disease
BackgroundProcess approach is valuable for memory assessment in Alzheimer’s disease (AD) and mild cognitive impairment (MCI), yet its underlying...
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Mutation ∆K281 in MAPT causes Pick’s disease
Two siblings with deletion mutation ∆K281 in MAPT developed frontotemporal dementia. At autopsy, numerous inclusions of hyperphosphorylated 3R Tau...
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Functional neurological symptoms as initial presentation of Creutzfeldt-Jakob disease: case series
BackgroundFunctional Neurological Disorders (FND) are common in clinical practice. It is recognized that FND may present at onset or during the...
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Biomarker-based staging of Alzheimer disease: rationale and clinical applications
Disease staging, whereby the spatial extent and load of brain pathology are used to estimate the severity of Alzheimer disease (AD), is pivotal to...
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Whole-brain morphological alterations associated with trigeminal neuralgia
BackgroundNovel neuroimaging strategies have the potential to offer new insights into the mechanistic basis for trigeminal neuralgia (TN). The...
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Regional AT-8 reactive tau species correlate with intracellular Aβ levels in cases of low AD neuropathologic change
The amyloid cascade hypothesis states that Aβ aggregates induce pathological changes in tau, leading to neurofibrillary tangles (NFTs) and cell...
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Alzheimer disease neuropathology in a patient previously treated with aducanumab
Amyloid beta (Aβ) plaque is a defining pathologic feature of Alzheimer disease (AD). Aducanumab, a monoclonal IgG1 that selectively binds aggregated...
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Individual cerebellar metabolic connectome in patients with MTLE and NTLE associated with surgical prognosis
PurposeThis study aimed to comprehensively explore the different metabolic connectivity topological changes in MTLE and NTLE, as well as their...
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Differential associations between neocortical tau pathology and blood flow with cognitive deficits in early-onset vs late-onset Alzheimer’s disease
PurposeEarly-onset Alzheimer’s disease (EOAD) and late-onset Alzheimer’s disease (LOAD) differ in neuropathological burden and type of cognitive...
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Staging tau pathology with tau PET in Alzheimer’s disease: a longitudinal study
A biological research framework to define Alzheimer’ disease with dichotomized biomarker measurement was proposed by National Institute on...
