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Calorie restriction-induced leptin reduction and T-lymphocyte activation in blood and adipose tissue in men with overweight and obesity
BackgroundT-Lymphocyte activation is modulated by the adipokine leptin and serum concentrations of this hormone can be reduced with short-term...
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Monomorphic T-cell post-transplant lymphoproliferative disorder with features of HHV8-negative primary effusion lymphoma: an autopsy case and review of the literature
A 67-year-old man underwent renal transplantation in his twenties. He developed refractory pleural effusion, with many large lymphocytes with severe...
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Clinical implications of aberrant PD-1 expression for acute leukemia prognosis
BackgroundAcute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) are the most common types of leukemia in adults with an overall poor...
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Cytotoxic T lymphocyte antigen-4 (CTLA-4) expression in chordoma and tumor-infiltrating lymphocytes (TILs) predicts prognosis of spinal chordoma
PurposeChordoma is a rare tumor of the skeletal system that is characterized by a high recurrence rate and treatment resistance. Given the common...
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10 ns PEFs induce a histological response linked to cell death and cytotoxic T-lymphocytes in an immunocompetent mouse model of peritoneal metastasis
PurposeThe application of nanosecond pulsed electric fields (nsPEFs) could be an effective therapeutic strategy for peritoneal metastasis (PM) from...
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PTPN3 expressed in activated T lymphocytes is a candidate for a non-antibody-type immune checkpoint inhibitor
It has been shown that protein tyrosine phosphatase non-receptor type (PTPN) 3 inhibits T-cell activation. However, there is no definitive conclusion...
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Differential expression of Tim-3, PD-1, and CCR5 on peripheral T and B lymphocytes in hepatitis C virus-related hepatocellular carcinoma and their impact on treatment outcomes
Background and objectiveActivation of the immune checkpoints and expression of chemokines and chemokine receptors have been reported to promote HCC...
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Relationship of thymic area with clinical-epidemiological variables and values of T-lymphocyte subpopulations in peripheral blood of children with recurrent infections
BackgroundRecurrent infections in childhood are the main cause of remission to the immunology service. T lymphocytes generated in the thymus are...
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Digital pathology-aided assessment of tumor-infiltrating T lymphocytes in advanced stage, HPV-negative head and neck tumors
AimThis study aimed to evaluate the presence and prognostic value of tumor-infiltrating T cells in the tumor epithelium in advanced stage,...
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Role of T Lymphocytes in HIV Neuropathogenesis
Purpose of ReviewThe purpose of this review is to summarize the current knowledge on the role of CD4 + T lymphocytes leading to HIV assault and...
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Effect of siponimod on lymphocyte subsets in active secondary progressive multiple sclerosis and clinical implications
BackgroundCirculating immune cells play a pathogenic role in multiple sclerosis (MS). However, the role of specific lymphocyte subpopulations is not...
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Chronic TCR-MHC (self)-interactions limit the functional potential of TCR affinity-increased CD8 T lymphocytes
BackgroundAffinity-optimized T cell receptor (TCR)-engineered lymphocytes targeting tumor antigens can mediate potent antitumor responses in cancer...
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Flow cytometric characterization of cecal appendix lymphocyte subpopulations in children: a pilot study
IntroductionScientific literature regarding the characterization of lymphocyte subpopulations of the cecal appendix is sparse, with few precedents...
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T cells: an emerging cast of roles in bipolar disorder
Bipolar disorder (BD) is a distinctly heterogeneous and multifactorial disorder with a high individual and social burden. Immune pathway...
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Synergist for antitumor therapy: Astragalus polysaccharides acting on immune microenvironment
Various new treatments are emerging constantly in anti-tumor therapies, including chemotherapy, immunotherapy, and targeted therapy. However, the...
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Activation of cytotoxic lymphocytes through CD6 enhances killing of cancer cells
Immune checkpoint inhibitors (ICIs) have demonstrated efficacy and improved survival in a growing number of cancers. Despite their success, ICIs are...
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Autologous anti-GD2 CAR T cells efficiently target primary human glioblastoma
Glioblastoma (GBM) remains a deadly tumor. Treatment with chemo-radiotherapy and corticosteroids is known to impair the functionality of lymphocytes,...
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Quantitative analysis of Tr1 lymphocytes in patients with type 2 diabetes mellitus
BackgroundType 2 diabetes mellitus (T2DM) is usually accompanied by a low-grade inflammatory phenomenon, which participates in the pathogenesis of...
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Exploring the clinical application value of peripheral blood T lymphocyte subset in patients with asymptomatic omicron infection
ObjectiveTo investigate the clinical significance and value of peripheral blood T lymphocyte subset in patients with asymptomatic novel coronavirus...
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Peripheral blood lymphocyte subsets in children with nephrotic syndrome: a retrospective analysis
BackgroundNephrotic syndrome (NS) in children is widely believed to be associated with severe changes in the immune system. Based on lymphocyte...
