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Role of Interphase FISH Assay on Air-Dried Smears in Identifying Specific Structural Chromosomal Abnormalities among Pediatric Patients with Acute Leukemias
Leukemia-associated structural chromosomal abnormalities (SCA) can be identified either by karyoty** or interphase-fluorescence in-situ...
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Clinicopathologic features and genomic profiling of female axillary lymph node metastases from adenocarcinoma or poorly differentiated carcinoma of unknown primary
PurposeAxillary lymph node metastases from adenocarcinoma or poorly differentiated carcinoma of unknown primary (CUPAx) is a rare disease in women....
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A novel network pharmacology approach for leukaemia differentiation therapy using Mogrify®
Acute myeloid leukaemia (AML) is a rapidly fatal blood cancer that is characterised by the accumulation of immature myeloid cells in the blood and...
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Possible progressive multifocal leukoencephalopathy and active multiple sclerosis under dimethyl fumarate: the central role of MRI in informing therapeutic decisions
BackgroundProgressive multifocal leukoencephalopathy (PML) can rarely occur in Multiple Sclerosis (MS) patients undergoing dimethyl fumarate (DMF)...
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Immune checkpoint inhibitors for progressive multifocal leukoencephalopathy: a new gold standard?
ObjectivesProgressive multifocal leukoencephalopathy (PML) is a very rare and opportunistic encephalitis caused by JC polyomavirus that is linked to...
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Predictive values of plasma TNFα and IL-8 for intracranial hemorrhage in patients with acute promyelocytic leukemia
In patients with acute promyelocytic leukemia (APL), intracranial hemorrhage (ICH), if not identified promptly, could be fatal. It is the leading...
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Progressive multifocal leukoencephalopathy in a patient with novel mutation in the RAC2 gene: a case report
BackgroundProgressive multifocal leukoencephalopathy is a rare demyelinating disease that is often secondary to lytic destruction of oligodendrocytes...
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Progressive multifocal leukoencephalopathy and the spectrum of JC virus-related disease
Progressive multifocal leukoencephalopathy (PML) is a devastating CNS infection caused by JC virus (JCV), a polyomavirus that commonly establishes...
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BRD4 interacts with PML/RARα in acute promyelocytic leukemia
Bromodomain-containing 4 (BRD4) has been considered as an important requirement for disease maintenance and an attractive therapeutic target for...
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Acute Promyelocytic Leukemia with t(2;3): An Unusual Additional Chromosomal Abnormality
Acute promyelocytic leukemia is a distinct subset of acute myeloid leukemia with characteristic clinical, morphological and genetic features. The...
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Progressive multifocal leukoencephalopathy in multiple myeloma. A literature review and lessons to learn
Progressive multifocal leukoencephalopathy (PML) is a rare opportunistic infection with high mortality rate usually seen in the context of...
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Case of acute promyelocytic leukemia with basophilic differentiation and an ETV6 mutation
The translocation between chromosomes 15 and 17 t(15;17) at the promyelocytic leukemia (PML) and retinoic acid receptor alpha (RARA) is thought to be...
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Clinical Improvement of Progressive Multifocal Leukoencephalopathy Following Pembrolizumab Infusion: a Case Report
Progressive multifocal leukoencephalopathy (PML) is a rare opportunistic brain infection caused by the John Cunningham (JC) virus, the cardinal...
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Long-term follow-up (up to 11 years) of an Italian pediatric MS cohort treated with Natalizumab: a multicenter, observational study
BackgroundNatalizumab (NAT) has a strong impact on disease activity of aggressive pediatric multiple sclerosis (MS), with no difference in safety...
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Autoantibodies to speckled protein family in primary biliary cholangitis
The autoantibody profile of primary biliary cholangitis (PBC) includes antinuclear antibodies (ANA) which are detectable by indirect...
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Progressive multifokale Leukenzephalopathie – ein Update
Progressive multifocal leukoencephalopathy (PML) is a disease of the central nervous system elicited by the JC polyomavirus (JCV) mainly in...
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STMN1 is highly expressed and contributes to clonogenicity in acute promyelocytic leukemia cells
Stathmin 1 (STMN1) is a microtubule-destabilizing protein highly expressed in hematological malignancies and involved in proliferation and...
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All-trans Retinoic Acid, Arsenic Trioxide, and Anthracycline-based Chemotherapy Improves Outcome in Newly Diagnosed Acute Promyelocytic Leukemia Regardless of FLT3-ITD Mutation Status
All-trans retinoic acid (ATRA) and pre-upfront arsenic trioxide (ATO) have revolutionized the therapy of acute promyelocytic leukemia (APL). However,...