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Plasma Proteomic Analysis Based on 4D-DIA Evaluates the Clinical Response to Imrecoxib in the Early Treatment of Osteoarthritis
IntroductionNonsteroidal anti-inflammatory drugs (NSAIDs) are the primary treatment for osteoarthritis (OA), but prolonged use has adverse effects...
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Predictive potential of various plasma inflammation-, angiogenesis-, and extracellular matrix remodeling-associated mediators for intra-amniotic inflammation and/or microbial invasion of the amniotic cavity in preterm labor
PurposeTo determine whether various inflammatory-, angiogenic/anti-angiogenic-, and extracellular matrix remodeling-associated proteins in plasma,...
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Identification of the immune-related biomarkers in Behcet’s disease by plasma proteomic analysis
BackgroundThis study aimed to investigate the expression profile of immune response-related proteins of Behcet’s disease (BD) patients and identify...
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High-throughput electron tomography identifies centriole over-elongation as an early event in plasma cell disorders
Plasma cell disorders are clonal outgrowths of pre-malignant or malignant plasma cells, characterized by extensive chromosomal aberrations....
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Identifying novel proteins for suicide attempt by integrating proteomes from brain and blood with genome-wide association data
Genome-wide association studies (GWASs) have identified risk loci for suicide attempt (SA), but deciphering how they confer risk for SA remains...
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Platelet-Rich Plasma Versus Platelet-Poor Plasma for Treating Facial Photoaging: a Double-Blind Randomized Controlled Splitting Face Study
BackgroundAs the demand for non-invasive esthetic procedures to maintain a youthful appearance increases, there has been growing interest in the use...
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Antimicrobial peptides and proteins as alternative antibiotics for porcine semen preservation
BackgroundAntimicrobial resistance (AMR) is nowadays a major emerging challenge for public health worldwide. The over- and misuse of antibiotics,...
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Validation of plasma protein glycation and oxidation biomarkers for the diagnosis of autism
Autism Spectrum Disorder (ASD) is a common neurodevelopmental disorder in children. It is currently diagnosed by behaviour-based assessments made by...
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The role of Motin family proteins in tumorigenesis—an update
The Motin protein family consists of three members: AMOT (p80 and p130 isoforms), AMOT-like protein 1 (AMOTL1), and AMOT-like protein 2 (AMOTL2). The...
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Quercetin Attenuates Atherosclerosis via Modulating Apelin Signaling Pathway Based on Plasma Metabolomics
ObjectiveTo interpret the pharmacology of quercetin in treatment of atherosclerosis (AS).
MethodsFourteen apolipoprotein E-deficient (ApoE −/− ) mice...
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Diagnostic value of plasma-derived exosomal miR-223 for epithelial ovarian cancer
ObjectivesTo evaluate the diagnostic value of plasma exosomal miR-223 and its combination with CA125 for the diagnosis of early-stage epithelial...
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Plasma Corin: A New Biochemical Marker for Polycystic Ovary Syndrome
IntroductionPolycystic ovary syndrome (PCOS) is a prevalent endocrine disorder. Atrial natriuretic peptide (ANP) is a risk factor for PCOS. Corin...
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Plasma neurofilament light as a promising biomarker in neuronal intranuclear inclusion disease
Neuronal intranuclear inclusion disease (NIID) is a rare neurodegenerative disorder lacking reliable biomarkers. This study investigates plasma...
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Elevated plasma protein carbonylation increases the risk of ischemic cerebrovascular events in patients with atrial fibrillation: association with a prothrombotic state
IntroductionPlasma protein carbonylation that reflects oxidative stress has been demonstrated to be associated with the prothrombotic fibrin clot...
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Characterization of translocon proteins in the type III secretion system of Lawsonia intracellularis
Lawsonia intracellularis , the etiologic agent of proliferative enteropathy (PE), is an obligate intracellular Gram-negative bacterium possessing a...
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Diagnostic role of plasma ORM2 in differentiating prostate cancer from benign prostatic hyperplasia
PurposeMarkers are needed to increase the diagnostic accuracy of prostate-specific antigen (PSA) in prostate cancer (PCa) screening. Mounting...
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Alternative splicing and related RNA binding proteins in human health and disease
Alternative splicing (AS) serves as a pivotal mechanism in transcriptional regulation, engendering transcript diversity, and modifications in protein...
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The role of miRNA-29b1, MMP-2, MMP-9 mRNAs, and proteins in early diagnosis of HCC
BackgroundHepatocellular carcinoma (HCC) is a common, serious malignancy with a dismal prognosis. As HCC is frequently missed in its early stages,...
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Identification of ER/SR resident proteins as biomarkers for ER/SR calcium depletion in skeletal muscle cells
BackgroundAberrations to endoplasmic/sarcoplasmic reticulum (ER/SR) calcium concentration can result in the departure of endogenous proteins in a...
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Placenta-derived proteins across gestation in healthy pregnancies—a novel approach to assess placental function?
BackgroundPlacenta-derived proteins in the systemic maternal circulation are suggested as potential biomarkers for placental function. However, the...
